Study of a New Quaternary Ammonium Derivative, Prantal, Capable of Reducing Gastric Secretions and Motility; Tests in Animals and Man, Trial in 44 Patients With Peptic Ulcer

Polyquaternium-10 is a polymeric quaternary ammonium derivative of hydroxyethyl cellulose that is used in cosmetics as a conditioner, thickener, and emollient at concentrations of ≤0.1%–5%. Polyquaternium-10 has, at most, only a low potential to penetrate the stratum corneum but is adsorbed by keratinous surfaces. The oral LD50 of Polyquaternium-10 was not obtained at 16 g/kg in rats. Inhalation, dermal, and ocular animal test data indicated, at most, only a low degree of toxicity at test concentrations of Polyquaternium-10 greater than that used in cosmetic products. Polyquaternium-10 with and without metabolic activation was not a mutagen in three separate assay systems. Polyquaternium-10 was neither an irritant nor a human sensitizer when tested at 2.0%. Cosmetic products containing up to 1% Polyquaternium-10 were not human irritants, sensitizers, or photosensitizers. On the basis of the information presented, it is concluded that Polyquaternium-10 is safe as a cosmetic ingredient in the present practices of use.

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Doxycycline and its quaternary ammonium derivative for adjuvant therapies of chondrosarcoma

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-017-3377-7 ◽

2017 ◽

Vol 80 (3) ◽

pp. 517-526 ◽

Cited By ~ 1

Author(s):

Imen Miladi ◽

Magali Vivier ◽

Marie-Mélanie Dauplat ◽

Morgane Chatard ◽

Sophie Besse ◽

...

Keyword(s):

Quaternary Ammonium ◽

Ammonium Derivative ◽

Adjuvant Therapies ◽

Quaternary Ammonium Derivative

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Synthesis and pharmacokinetic profile of a quaternary ammonium derivative of chlorambucil, a potential anticancer drug for the chemotherapy of chondrosarcoma

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2003.09.006 ◽

2003 ◽

Vol 11 (23) ◽

pp. 5007-5012 ◽

Cited By ~ 11

Author(s):

Maryse Rapp ◽

Isabelle Giraud ◽

Jean-Claude Maurizis ◽

Jean-Claude Madelmont

Keyword(s):

Anticancer Drug ◽

Quaternary Ammonium ◽

Pharmacokinetic Profile ◽

Ammonium Derivative ◽

Quaternary Ammonium Derivative

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The effect of propranolol and dimethylpropranolol on cardiac conduction

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y79-097 ◽

1979 ◽

Vol 57 (6) ◽

pp. 637-641 ◽

Cited By ~ 1

Author(s):

Peter E. Dresel ◽

Pamela Potter

Keyword(s):

Heart Rate ◽

Quaternary Ammonium ◽

Cardiac Conduction ◽

Conduction Time ◽

Av Node ◽

Heart Rates ◽

Ammonium Derivative ◽

Quaternary Derivative ◽

Quaternary Ammonium Derivative ◽

Ventricular Conduction

Isolated dog hearts perfused with blood from a donor dog and driven at two heart rates were used to compare the effects of propranolol with those of its quaternary ammonium derivative on atrial, atrioventricular (AV) nodal, and His-Purkinje conduction. Propranolol slowed only AV-nodal conduction, increasing the minimal conduction time and the effect of prematurity, without affecting fatigue. Practolol did not have this effect. Dimethylpropranolol had similar but not identical effects on the AV node, but also slowed atrial and ventricular conduction. In contrast with the quaternary derivative of lidocaine, dimethylpropranolol's effect on atrial and ventricular conduction was not dependent on the heart rate. The effect of dimethylpropranolol on ventricular conduction was observed at doses lower than those reported by others to be antiarrhythmic.

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Synthesis and moisture absorption and retention activities of a carboxymethyl and a quaternary ammonium derivative of α,α-trehalose

Carbohydrate Research ◽

10.1016/j.carres.2009.09.024 ◽

2010 ◽

Vol 345 (1) ◽

pp. 120-123 ◽

Cited By ~ 13

Author(s):

Shaoli Yang ◽

Zhanyong Guo ◽

Yuling Zhou ◽

Lili Zhou ◽

Qinzhao Xue ◽

...

Keyword(s):

Quaternary Ammonium ◽

Moisture Absorption ◽

Ammonium Derivative ◽

Quaternary Ammonium Derivative

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Quaternary Ammonium Derivative of Lidocaine as a Long-acting Local Anesthetic

Anesthesiology ◽

10.1097/00000542-199512000-00020 ◽

1995 ◽

Vol 83 (6) ◽

pp. 1293-1301 ◽

Cited By ~ 33

Author(s):

G. K. Wang ◽

C. Quan ◽

M. Vladimirov ◽

W. M. Mok ◽

J. G. Thalhammer

Keyword(s):

Pain Management ◽

Organic Synthesis ◽

Local Anesthetic ◽

Quaternary Ammonium ◽

Local Anesthetics ◽

Functional Testing ◽

Ammonium Derivative ◽

Neural Blockade ◽

Quaternary Ammonium Derivative ◽

Long Acting

Abstract Background Use of long-acting local anesthetics that elicit complete neural blockade for more than 3 h often is desirable in pain management. Unfortunately, clinically available local anesthetics are in general not suitable for prolonged analgesia. This report describes the organic synthesis and functional testing of a lidocaine derivative that appears to fulfill the criteria of long-acting local anesthetics.

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