The rate of false-positive results with EUS-guided fine-needle aspiration

2002 ◽  
Vol 56 (6) ◽  
pp. 868-872 ◽  
Author(s):  
David A. Schwartz ◽  
K.Krishnan Unni ◽  
Michael J. Levy ◽  
Jonathan E. Clain ◽  
Maurits J. Wiersema
Keyword(s):  
Fine Needle Aspiration ◽  
False Positive ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Positive Results

scholarly journals Correlation of fine needle aspiration cytology and histopathological examination in thyroid swellings: a prospective study

2019 ◽  
Vol 5 (3) ◽  
pp. 718
Author(s):  
Shenbagavalli S. ◽  
Muthukumar R.
Keyword(s):  
Physical Examination ◽  
Fine Needle Aspiration ◽  
False Positive ◽  
Histopathological Examination ◽  
False Negative ◽  
Needle Aspiration ◽  
Thyroid Function Tests ◽  
Benign Lesions ◽  
Fine Needle ◽  
Positive Results

<p class="abstract"><strong>Background:</strong> Thyroid swellings are not an uncommon condition. Physical examination, laboratory investigation, thyroid imaging, and cytology can be used to evaluate thyroid swellings. After a physical examination, ultrasonography and thyroid function tests, fine needle aspiration (FNA) cytology should be implemented. Although FNA cytology is a common method to evaluate the nodule, false negative and false positive results are not rare. Hence histopathology examination is confirmatory. Information gathered from history, physical examination, ultrasound and intraoperative appearance of thyroid swelling dictate further management. The purpose of the study is to correlate preoperative FNAC and postoperative histopathology in thyroid swellings.</p><p class="abstract"><strong>Methods:</strong> This study of 52 in-patients with thyroid lesions was treated at UIORL-RGGGH MMC Chennai. FNAC and USG were used as preoperative tools for determining the procedure to be performed and was followed by HPE postoperatively for further<strong> </strong>management.  </p><p class="abstract"><strong>Results:</strong> Diagnostic categorization of 52 thyroid swellings were based on FNAC and histopathology. According to FNAC, 88.46% swellings were benign lesions and 11.54% were a malignancy. According to HPE, 82.69% were benign lesions and 17.31% were a malignancy. In our study, the collection of thyroid cases emphasizes the false negativity of FNAC. Cases suspicious of malignancy were decided based on intraoperative changes and were given a note of caution to the pathologists for a meticulous evaluation of slides.</p><p class="abstract"><strong>Conclusions:</strong> FNAC is a simple, safe and cost-effective modality of investigation for thyroid disease but in cases of false negativity histopathology is confirmatory. The false positive results were found to be nil however there is a low percentage of false negative results which has to be confirmed by HPE.</p>

The rate of false-positive results with EUS-guided fine-needle aspiration

2002 ◽  
Vol 56 (6) ◽  
pp. 868-872
Author(s):  
David A. Schwartz ◽  
K. Krishnan Unni ◽  
Michael J. Levy ◽  
Jonathan E. Clain ◽  
Maurits J. Wiersema
Keyword(s):  
Fine Needle Aspiration ◽  
False Positive ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Positive Results

On Cytologic Vagaries in the Diagnosis of Breast Tumors

1980 ◽  
Vol 66 (2) ◽  
pp. 191-196 ◽  
Author(s):  
Tadeusz Biedrzycki ◽  
Maria Dabska ◽  
Ludwika Sikorowa ◽  
Tadeusz Kubicki
Keyword(s):  
Fine Needle Aspiration ◽  
False Positive ◽  
Fine Needle Aspiration Biopsy ◽  
False Negative ◽  
Breast Tumors ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Fine Needle ◽  
Biopsy Technique ◽  
Positive Results

The article describes the difficulties, the errors and limitations of the fine needle aspiration biopsy technique in the diagnosis of the breast tumors encountered during a 2.5 year period of activity. The question of false-negative and false-positive results and the way these problems were partly overcome in the Institute of Oncology in Warsaw are discussed in detail.

Pitfalls in Salivary Gland Fine-Needle Aspiration Cytology: Lessons From the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology

2005 ◽  
Vol 129 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Jonathan H. Hughes ◽  
Emily E. Volk ◽  
David C. Wilbur
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
False Positive ◽  
Interlaboratory Comparison ◽  
False Negative ◽  
Diagnostic Errors ◽  
Poor Performance ◽  
Needle Aspiration ◽  
Low Grade ◽  
Fine Needle

Abstract Context.—We use data from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology to identify common diagnostic errors in salivary gland fine-needle aspiration (FNA). Objective.—To identify salivary gland FNA cases with poor performance characteristics in the Nongynecologic Cytology Program surveys, so that the most common diagnostic pitfalls can be avoided. Design.—A retrospective review of the College of American Pathologists Nongynecologic Cytology Program's cumulative data from 1999 to 2003 revealed the most common false-positive and false-negative interpretations on FNA for common salivary gland lesions. Slides that performed poorly were then reviewed to identify the cytologic characteristics that may have contributed to their poor performance. Results.—A total of 6249 participant responses with general interpretations of benign (n = 4642) or malignant (n= 1607) were reviewed. The sensitivity and specificity of the participant responses for correctly interpreting the cases as benign or malignant were 73% and 91%, respectively. Benign cases with the highest false-positive rates were monomorphic adenoma (53% false-positive), intraparotid lymph node (36%), oncocytoma (18%), and granulomatous sialadenitis (10%). Malignant cases with the highest false-negative rates were lymphoma (57%), acinic cell carcinoma (49%), low-grade mucoepidermoid carcinoma (43%), and adenoid cystic carcinoma (33%). Selected review of the most discordant individual cases revealed possible explanations for some of the interpretative errors. Conclusions.—These data confirm the difficulty associated with interpretation of salivary gland FNA specimens. Cytologists should be aware of the potential false-positive and false-negative interpretations that can occur in FNAs from this organ site in order to minimize the possibility of diagnostic errors.

Rotterdam Criteria for Sentinel Node (SN) Tumor Burden and the Accuracy of Ultrasound (US) -Guided Fine-Needle Aspiration Cytology (FNAC): Can US-Guided FNAC Replace SN Staging in Patients With Melanoma?

2009 ◽  
Vol 27 (30) ◽  
pp. 4994-5000 ◽  
Author(s):  
Christiane A. Voit ◽  
Alexander C.J. van Akkooi ◽  
Gregor Schäfer-Hesterberg ◽  
Alfred Schoengen ◽  
Paul I.M. Schmitz ◽  
...  
Keyword(s):  
Sentinel Node ◽  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
The Us ◽  
Needle Aspiration Cytology ◽  
Positive Results

Purpose Sentinel node (SN) status is the most important prognostic factor for overall survival (OS) for patients with stage I/II melanoma, and the role of the SN procedure as a staging procedure has long been established. However, a less invasive procedure, such as ultrasound (US) -guided fine-needle aspiration cytology (FNAC), would be preferred. The aim of this study was to evaluate the accuracy of US-guided FNAC and compare the results with histology after SN surgery was performed in all patients. Patients and Methods Four hundred consecutive patients who underwent lymphoscintigraphy subsequently underwent a US examination before the SN procedure. When the US examination showed a suspicious or malignant pattern, patients underwent an FNAC. Median Breslow thickness was 1.8 mm; mean follow-up was 42 months (range, 4 to 82 months). We considered the US-guided FNAC positive if either US and/or FNAC were positive. If US was suggestive of abnormality, but FNAC was negative, the US-guided FNAC was considered negative. Results US-guided FNAC identified 51 (65%) of 79 SN metastases. Specificity was 99% (317 of 321), with a positive predictive value of 93% and negative predictive value of 92%. SN-positive identification rate by US-guided FNAC increased from 40% in stage pT1a/b disease to 79% in stage pT4a/b disease. US-guided FNAC detected SN tumors more than 1.0 mm in 86% of cases, SN tumors of 0.1 to 1.0 mm in 46% of cases, and SN tumors less than 0.1 mm in 23% of cases. Estimated 5-year OS rates were 92% for patients with negative US-guided FNAC results and 51% for patients with positive results. Conclusion US-guided FNAC of SNs is highly accurate. Up to 65% of the patients with SN-positive results in our institution could have been spared an SN procedure.

False-positive diagnosis in fine-needle aspiration of an atypical Warthin's tumor: Histochemical differential stains for cytodiagnosis

1989 ◽  
Vol 5 (4) ◽  
pp. 412-415 ◽  
Author(s):  
Rodolfo Laucirica ◽  
James B. Farnum ◽  
Sophie K. Leopold ◽  
George B. Kalin ◽  
George A. Youngberg
Keyword(s):  
Fine Needle Aspiration ◽  
False Positive ◽  
Needle Aspiration ◽  
Warthin’S Tumor ◽  
Fine Needle ◽  
Positive Diagnosis ◽  
False Positive Diagnosis ◽  
Warthin's Tumor

False-positive and false-negative cases of fine-needle aspiration cytology for palpable breast lesions

Breast Cancer ◽  
2007 ◽  
Vol 14 (4) ◽  
pp. 388-392 ◽  
Author(s):  
Takashi Ishikawa ◽  
Yohei Hamaguchi ◽  
Mikiko Tanabe ◽  
Nobuyoshi Momiyama ◽  
Takashi Chishima ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
False Positive ◽  
Fine Needle Aspiration Cytology ◽  
False Negative ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Palpable Breast ◽  
Needle Aspiration Cytology

Parotid Tumors: Fine-Needle Aspiration and/or Frozen Section

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P42-P43
Author(s):  
Peter Zbaren ◽  
Heinz Loosli ◽  
Edouard Stauffer
Keyword(s):  
Sensitivity And Specificity ◽  
Fine Needle Aspiration ◽  
False Positive ◽  
Frozen Section ◽  
False Negative ◽  
Needle Aspiration ◽  
True Positive ◽  
True Negative ◽  
Fine Needle ◽  
Parotid Neoplasms

Objective Assess the difficulties of preoperative and intraoperative tumor typing of parotid neoplasms. Know the advantages and pitfalls of fine-needle-aspiration cytology (FNAC) and frozen section (FS) analysis in primary parotid neoplasms. Methods In 113 parotid neoplasms (70 malignancies and 43 benign tumors) preoperative FNAC as well as intraoperative FS analysis were performed. FNAC and FS findings were analyzed and compared with the final histopathologic diagnosis. Results The FNAC smear was non-diagnostic in 6 tumors. In 2 FS specimens, it was not possible to determine the tumor dignity. FNAC findings and FS findings were both available in 105 neoplasMS The FNAC findings were true positive for malignancy in 54, true negative in 36, false positive in 4, and false negative in 11 tumors. The accuracy, sensitivity, and specificity were 86%, 83%, and 90% respectively. The FS findings were true positive in 60, true negative in 38, false positive in 2, and false negative in 5 tumors. The accuracy, sensitivity, and specificity were 93%, 92% and 95% respectively. The exact histologic tumor typing by FNAC was correct, false or not mentioned in 58%, 20% and 22% true positive or true negative evaluated tumors, and by FS in 83%, 5% and 12% true positive or true negative evaluated tumors. Conclusions The current analysis showed a superiority of FS compared with FNAC regarding the diagnosis of malignancy and especially of tumor typing. FNAC alone is not prone in many cases to determine the surgical management of primary parotid carcinomas.

Sign in / Sign up

Export Citation Format

Share Document