Correlation of fine needle aspiration cytology and histopathological examination in thyroid swellings: a prospective study

Background: Thyroid swellings are not an uncommon condition. Physical examination, laboratory investigation, thyroid imaging, and cytology can be used to evaluate thyroid swellings. After a physical examination, ultrasonography and thyroid function tests, fine needle aspiration (FNA) cytology should be implemented. Although FNA cytology is a common method to evaluate the nodule, false negative and false positive results are not rare. Hence histopathology examination is confirmatory. Information gathered from history, physical examination, ultrasound and intraoperative appearance of thyroid swelling dictate further management. The purpose of the study is to correlate preoperative FNAC and postoperative histopathology in thyroid swellings.Methods: This study of 52 in-patients with thyroid lesions was treated at UIORL-RGGGH MMC Chennai. FNAC and USG were used as preoperative tools for determining the procedure to be performed and was followed by HPE postoperatively for further management. Results: Diagnostic categorization of 52 thyroid swellings were based on FNAC and histopathology. According to FNAC, 88.46% swellings were benign lesions and 11.54% were a malignancy. According to HPE, 82.69% were benign lesions and 17.31% were a malignancy. In our study, the collection of thyroid cases emphasizes the false negativity of FNAC. Cases suspicious of malignancy were decided based on intraoperative changes and were given a note of caution to the pathologists for a meticulous evaluation of slides.Conclusions: FNAC is a simple, safe and cost-effective modality of investigation for thyroid disease but in cases of false negativity histopathology is confirmatory. The false positive results were found to be nil however there is a low percentage of false negative results which has to be confirmed by HPE.

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On Cytologic Vagaries in the Diagnosis of Breast Tumors

Tumori Journal ◽

10.1177/030089168006600207 ◽

1980 ◽

Vol 66 (2) ◽

pp. 191-196 ◽

Cited By ~ 7

Author(s):

Tadeusz Biedrzycki ◽

Maria Dabska ◽

Ludwika Sikorowa ◽

Tadeusz Kubicki

Keyword(s):

Fine Needle Aspiration ◽

False Positive ◽

Fine Needle Aspiration Biopsy ◽

False Negative ◽

Breast Tumors ◽

Needle Aspiration ◽

Aspiration Biopsy ◽

Fine Needle ◽

Biopsy Technique ◽

Positive Results

The article describes the difficulties, the errors and limitations of the fine needle aspiration biopsy technique in the diagnosis of the breast tumors encountered during a 2.5 year period of activity. The question of false-negative and false-positive results and the way these problems were partly overcome in the Institute of Oncology in Warsaw are discussed in detail.

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Pitfalls in Salivary Gland Fine-Needle Aspiration Cytology: Lessons From the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology

Archives of Pathology & Laboratory Medicine ◽

10.5858/2005-129-26-pisgfc ◽

2005 ◽

Vol 129 (1) ◽

pp. 26-31 ◽

Cited By ~ 19

Author(s):

Jonathan H. Hughes ◽

Emily E. Volk ◽

David C. Wilbur

Keyword(s):

Salivary Gland ◽

Fine Needle Aspiration ◽

False Positive ◽

Interlaboratory Comparison ◽

False Negative ◽

Diagnostic Errors ◽

Poor Performance ◽

Needle Aspiration ◽

Low Grade ◽

Fine Needle

Abstract Context.—We use data from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology to identify common diagnostic errors in salivary gland fine-needle aspiration (FNA). Objective.—To identify salivary gland FNA cases with poor performance characteristics in the Nongynecologic Cytology Program surveys, so that the most common diagnostic pitfalls can be avoided. Design.—A retrospective review of the College of American Pathologists Nongynecologic Cytology Program's cumulative data from 1999 to 2003 revealed the most common false-positive and false-negative interpretations on FNA for common salivary gland lesions. Slides that performed poorly were then reviewed to identify the cytologic characteristics that may have contributed to their poor performance. Results.—A total of 6249 participant responses with general interpretations of benign (n = 4642) or malignant (n= 1607) were reviewed. The sensitivity and specificity of the participant responses for correctly interpreting the cases as benign or malignant were 73% and 91%, respectively. Benign cases with the highest false-positive rates were monomorphic adenoma (53% false-positive), intraparotid lymph node (36%), oncocytoma (18%), and granulomatous sialadenitis (10%). Malignant cases with the highest false-negative rates were lymphoma (57%), acinic cell carcinoma (49%), low-grade mucoepidermoid carcinoma (43%), and adenoid cystic carcinoma (33%). Selected review of the most discordant individual cases revealed possible explanations for some of the interpretative errors. Conclusions.—These data confirm the difficulty associated with interpretation of salivary gland FNA specimens. Cytologists should be aware of the potential false-positive and false-negative interpretations that can occur in FNAs from this organ site in order to minimize the possibility of diagnostic errors.

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False-positive and false-negative cases of fine-needle aspiration cytology for palpable breast lesions

Breast Cancer ◽

10.2325/jbcs.14.388 ◽

2007 ◽

Vol 14 (4) ◽

pp. 388-392 ◽

Cited By ~ 29

Author(s):

Takashi Ishikawa ◽

Yohei Hamaguchi ◽

Mikiko Tanabe ◽

Nobuyoshi Momiyama ◽

Takashi Chishima ◽

...

Keyword(s):

Fine Needle Aspiration ◽

False Positive ◽

Fine Needle Aspiration Cytology ◽

False Negative ◽

Needle Aspiration ◽

Breast Lesions ◽

Aspiration Cytology ◽

Fine Needle ◽

Palpable Breast ◽

Needle Aspiration Cytology

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Parotid Tumors: Fine-Needle Aspiration and/or Frozen Section

Otolaryngology ◽

10.1016/j.otohns.2008.05.139 ◽

2008 ◽

Vol 139 (2_suppl) ◽

pp. P42-P43

Author(s):

Peter Zbaren ◽

Heinz Loosli ◽

Edouard Stauffer

Keyword(s):

Sensitivity And Specificity ◽

Fine Needle Aspiration ◽

False Positive ◽

Frozen Section ◽

False Negative ◽

Needle Aspiration ◽

True Positive ◽

True Negative ◽

Fine Needle ◽

Parotid Neoplasms

Objective Assess the difficulties of preoperative and intraoperative tumor typing of parotid neoplasms. Know the advantages and pitfalls of fine-needle-aspiration cytology (FNAC) and frozen section (FS) analysis in primary parotid neoplasms. Methods In 113 parotid neoplasms (70 malignancies and 43 benign tumors) preoperative FNAC as well as intraoperative FS analysis were performed. FNAC and FS findings were analyzed and compared with the final histopathologic diagnosis. Results The FNAC smear was non-diagnostic in 6 tumors. In 2 FS specimens, it was not possible to determine the tumor dignity. FNAC findings and FS findings were both available in 105 neoplasMS The FNAC findings were true positive for malignancy in 54, true negative in 36, false positive in 4, and false negative in 11 tumors. The accuracy, sensitivity, and specificity were 86%, 83%, and 90% respectively. The FS findings were true positive in 60, true negative in 38, false positive in 2, and false negative in 5 tumors. The accuracy, sensitivity, and specificity were 93%, 92% and 95% respectively. The exact histologic tumor typing by FNAC was correct, false or not mentioned in 58%, 20% and 22% true positive or true negative evaluated tumors, and by FS in 83%, 5% and 12% true positive or true negative evaluated tumors. Conclusions The current analysis showed a superiority of FS compared with FNAC regarding the diagnosis of malignancy and especially of tumor typing. FNAC alone is not prone in many cases to determine the surgical management of primary parotid carcinomas.

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Accuracy of Fine-Needle Aspiration of Thyroid

Archives of Pathology & Laboratory Medicine ◽

10.5858/2001-125-0484-aofnao ◽

2001 ◽

Vol 125 (4) ◽

pp. 484-488 ◽

Cited By ~ 13

Author(s):

Mojghan Amrikachi ◽

Ibrahim Ramzy ◽

Sheldon Rubenfeld ◽

Thomas M. Wheeler

Keyword(s):

Fine Needle Aspiration ◽

False Positive ◽

Thyroid Nodules ◽

False Negative ◽

Cost Effective ◽

Needle Aspiration ◽

Follicular Neoplasm ◽

Follicular Variant ◽

Fine Needle

Abstract Context.—Fine-needle aspiration has become an accepted and cost-effective procedure for rapid diagnosis of thyroid lesions. The routine use of fine-needle aspiration has reduced the rate of unnecessary surgery for thyroid nodules. Objectives.—To determine the accuracy of fine-needle aspiration biopsy diagnosis and to discuss the possible pitfalls. Design, Setting, and Participants.—Reports of 6226 fine-needle aspiration biopsies of the thyroid performed during a period of 16 years (1982–1998) were reviewed. Computerized reports of the fine-needle aspiration biopsies were sent to the physicians who performed the procedures, and clinical follow-up information regarding the patients was requested. Twenty-four clinicians participated in the study. Histologic diagnoses were available for 354 cases. The cytopathologic diagnoses were correlated with the histologic findings or clinical outcomes. Results.—The cytologic diagnoses were as follows: 210 (3.4%) malignant, 450 (7.2%) suspicious, 3731 (60%) benign, and 1845 (29.5%) unsatisfactory. Most of the cases with negative or unsatisfactory aspirates were followed clinically or by repeat fine-needle aspiration. We identified 11 false-negative and 7 false-positive diagnoses. For aspirates considered sufficient for diagnosis, the sensitivity and specificity levels were 93% and 96%, respectively. Conclusions.—Fine-needle aspiration of the thyroid gland is highly accurate and has a low rate of false-negative and false-positive diagnoses. The major diagnostic problems are caused by diagnosis using a marginally adequate specimen, diagnosis of malignancy based on just 1 or 2 atypical cytologic features, or overlapping cytologic features of follicular neoplasm with those of follicular variant of papillary carcinoma.

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CT Imaging of Primary Lung Tumours with CT Guided Fine Needle Aspiration Cytology Correlation among Guwahati, Assam Population

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/522 ◽

2021 ◽

Vol 8 (31) ◽

pp. 2855-2864

Author(s):

Ashok Kumar ◽

Anil Kumar Geetha Virupakshappa ◽

Sushma Kenkare Lokanatha

Keyword(s):

Computed Tomography ◽

Fine Needle Aspiration ◽

Histopathological Examination ◽

False Negative ◽

Needle Aspiration ◽

Lung Tumour ◽

Ct Guided ◽

Fine Needle ◽

Lung Tumours ◽

Neoplastic Lesions

BACKGROUND The primary lung masses (tumours) are those that originate from the lung tissue. Although most primary pulmonary tumours are carcinomas, a large histological spectrum of benign and malignant tumours of the lung exists. Although chest xray is still considered to be the primary imaging modality of lungs, computed tomography (CT) not only shows the segments that are involved but also the extent of involvement. We wanted to study the sensitivity and specificity of CT in the diagnosis of primary neoplastic lesions of lung, study the CT patterns of different histological variants of bronchogenic carcinoma, and correlate CT findings with CT guided fine needle aspiration and cytology (FNAC) findings. METHODS The present descriptive cross-sectional study was conducted among 34 patients suspected clinically of having lung neoplasms, in Gauhati Medical College and Hospital, Guwahati, Assam from December 2010 to November 2011. RESULTS Considering FNAC / histopathological examination (HPE) as the gold standard, the positive predictive value and false negative value of CT scan for diagnosis of neoplastic lesions of lung were 97 % and 3 % respectively, in our study. Among our study population, mean age with lung tumours was 61 years, highest number of cases was seen in the age group of 51 - 60 years (35 %); Males and females affected were 27 (79.41 %), and 7 in number (20.59 %), respectively. CONCLUSIONS CT is more sensitive in the detection of neoplastic lesions of the lung and associated hilar / mediastinal adenopathy than chest roentgenography. CT has a high efficacy in detecting neoplastic lesions of lung, delineating its lobar and segmental anatomy, thereby helping surgical resection of lung. In this study, CT guided FNAC and cytological findings correlated well with CT diagnosis of primary neoplastic lesions of lung. KEYWORDS Primary Lung Tumour, Contrast Enhanced Computed Tomography (CECT), Fine Needle Aspiration and Cytology (FNAC)

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The fine-needle aspiration biopsy efficacy of small thyroid nodules in the area of recently normalized iodine supply

Acta Endocrinologica ◽

10.1530/eje-08-0524 ◽

2008 ◽

Vol 159 (6) ◽

pp. 747-754 ◽

Cited By ~ 3

Author(s):

Dorota Słowińska-Klencka ◽

Bożena Popowicz ◽

Andrzej Lewiński ◽

Stanisław Sporny ◽

Mariusz Klencki

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Biopsy ◽

Histopathological Examination ◽

False Negative ◽

Needle Aspiration ◽

Aspiration Biopsy ◽

Fine Needle ◽

Iodine Supply ◽

Needle Aspiration Biopsy ◽

Thyroid Lesions

ObjectiveTo evaluate the incidence of focal lesions in the thyroid in the area of recently normalized iodine supply as well as to compare the efficacy of fine-needle aspiration biopsy (FNAB) of small (infracentimetric) and large thyroid lesions in this area.MethodsThe outcomes of 13 646 ultrasound (US) examinations, 13 437 US-guided FNABs of the thyroid and 1694 results of post-operative histopathological examinations were analysed.ResultsInfracentimetric nodules (INs ≤10 mm) were revealed by US examinations in 43.5% of patients; in the majority of the cases (82.2%) INs were multiple. The percentage of revealed carcinomas by aspiration of INs is similar to that observed when large nodules (LNs >10 mm) are examined cytologically. However, the efficiency of preoperative diagnosis of INs is lower than LNs with respect to both US selection of lesions for FNAB and the percentage of false negative results of FNAB (29.8 vs 5.4%, P<0.001). In post-operative histopathological examination, extrathyroidal extension of thyroid cancers was observed in nearly 30% of microcarcinomas.ConclusionsIn endemic or post-endemic areas, the efficiency of FNAB is lower in the case of small lesions than larger ones. In spite of this, the percentage of cytologically revealed carcinomas among small lesions is not lower than larger ones. Thus, it is particularly indicated to follow up small thyroid lesions with repeated US examinations in such areas.

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