P43 A random prospective comparative study to evaluate the efficacy of intravenous iron sucrose versus oral ferrous sulphate in the treatment of iron deficiency anaemia of pregnancy

Background: Iron deficiency anaemia is one of the major morbidities during post-partum period. The aim of this study was to compare the efficacy, safety and compliance of intravenous iron sucrose complex with oral Iron therapy in treatment of postpartum anemia.Methods: 100 postpartum anaemic patients randomized into two groups. In Group I oral iron ferrous sulphate tablets twice daily and in group II 200 mg of iron sucrose on every alternate day up to total calculated dose for 6 weeks. Hemoglobin and serum ferritin were measured on day 0, 2 week and 6 weeks. The side effects in both groups were noted.Results: Majority of patients are multiparous, illiterate and belonged to low socioeconomic. Mean baseline hemoglobin in oral group (Group I) was 7.90±0.905 gm /dl and in i/v group (Group II) was 7.81±0.849 gm /dl. There was significant rise in hemoglobin and hematocrit in both groups after 2 weeks and 6 weeks. However, efficiency of iron sucrose was greater in between the groups (p value=0.0000). There was a rise in serum ferritin to 58.35±14.537μg/L from 8.30±1,461μg/L after 6 weeks in intravenous group with shorter duration of treatment indicating a high efficacy (p<0.001). Intravenous iron sucrose did not result in any serious adverse reactions.Conclusions: This study illustrates clearly that intravenous iron sucrose complex is safe, convenient and effective in postpartum anemic women as compared with oral ferrous sulphate.

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COMPARATIVE STUDY OF INTRAVENOUS IRON SUCROSE AND ORAL IRON IN IRON DEFICIENCY ANAEMIA AMONG PREGNANT WOMEN IN RURAL

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/326 ◽

2013 ◽

Vol 2 (7) ◽

pp. 695-701 ◽

Cited By ~ 1

Author(s):

Meenal C ◽

Hiremath P.B ◽

Nidhi Bansal ◽

Thirunaaukarasu Thirunaaukarasu ◽

Srikanth S ◽

...

Keyword(s):

Iron Deficiency ◽

Comparative Study ◽

Pregnant Women ◽

Iron Deficiency Anaemia ◽

Intravenous Iron ◽

Oral Iron ◽

Iron Sucrose ◽

Deficiency Anaemia

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Evaluation of the efficacy, tolerability and safety of multiple dose intravenous iron sucrose v/s intravenous ferric carboxymaltose in iron deficiency anaemia in postnatal women

MedPulse International Journal of Gynecology ◽

10.26611/101212210 ◽

2019 ◽

Vol 12 (2) ◽

pp. 57-59

Author(s):

Hemlata Jharbade ◽

Keyword(s):

Iron Deficiency ◽

Multiple Dose ◽

Iron Deficiency Anaemia ◽

Intravenous Iron ◽

Iron Sucrose ◽

Ferric Carboxymaltose ◽

Deficiency Anaemia ◽

Postnatal Women

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Study of outcome of the treatment with intravenous iron sucrose in moderately anaemic pregnant women

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20193695 ◽

2019 ◽

Vol 8 (9) ◽

pp. 3480

Author(s):

Kohila Kalimuthu ◽

Vanusha Avudaithangam

Keyword(s):

Standard Deviation ◽

Iron Deficiency ◽

Pregnant Women ◽

Iron Deficiency Anaemia ◽

Intravenous Iron ◽

Iron Sucrose ◽

P Value ◽

Deficiency Anaemia ◽

The Mean ◽

The Difference

Background: Moderate anaemia seen in about 15-20% of pregnant women. Iron sucrose complex which is used intravenously for the correction of Iron deficiency anaemia. The drug has been able to raise the haemoglobin to satisfactory level when used in moderately anaemic iron deficient pregnant women. The objective of this study was to study the improvement of Hb% after treatment with intravenous Iron sucrose complex in moderately anaemic pregnant women belonging to 24-32 weeks of gestational age.Methods: 50 antenatal patients between gestational age 24-32 weeks with hemoglobin between 8-9.5g/dl were selected and included in this study. They were subjected to blood hemoglobin estimation, hematocrit and peripheral smear study. In each infusion, the maximum total dose administered was 200 mg iron sucrose in 100 ml of normal saline, slow IV infused over 30 minutes. Monitoring was done throughout the infusion to observe for any side effects.Results: Mean hemoglobin among the 50 patients before starting the therapy was 8.172g/dl and the mean hemoglobin at the end of one month of completing the therapy was 11.066g/dl. The rise in mean hemoglobin i.e. the difference in the mean hemoglobin before and after treatment was 2.894g/dl. The p value is 0.0001 which is statistically significant. The mean hematocrit of the 50 patients studied before starting the treatment was 26.772% with a standard deviation of 1.914. The mean hematocrit after completing the therapy was 33.872% with a standard deviation of 1.321. The difference in the mean hematocrit was 7.100% with a p value of 0.0001 which is statistically significant.Conclusions: Intravenous iron sucrose complex is well tolerated and highly efficacious in improving hemoglobin, hematocrit in the treatment of iron deficiency anaemia in antenatal women.

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Intravenous versus oral iron therapy in treatment of postpartum anaemia

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20173462 ◽

2017 ◽

Vol 6 (8) ◽

pp. 3454

Author(s):

Neelima Agarwal ◽

Preeti Sharma

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anaemia ◽

Ferrous Sulphate ◽

Intravenous Iron ◽

Hemoglobin Level ◽

Oral Iron ◽

Chi Square ◽

Deficiency Anaemia ◽

Significant Difference ◽

Red Cell Indices

Background: Postpartum iron deficiency anaemia (IDA) is common in women. Most women are treated with either oral iron supplementation or blood transfusion. Hence, the aim of our study was to compare the effect of treatment with either oral ferrous sulphate or intravenous ferrous sucrose on postpartum IDA.Methods: 100 postpartum women with proven iron deficiency anaemia with hemoglobin <9gm/dl and serum ferritin <15 µgm/l were included in the study. They were randomized to receive either oral ferrous sulphate 200 mg twice daily for 6 weeks (group 1) or intravenous ferrous sucrose 200 mg, two to three doses given on alternate days (group 2). Total iron deficit was calculated using a standard formula. Target hemoglobin was 11 gm/dl. Results were analysed by the students t-test and chi-square test. Hemoglobin, hematocrit, red cell indices and ferritin were measured on day 2-3, 1-2 weeks and 6 weeks postpartumResults: By 1-2 weeks, hemoglobin level in women treated with intravenous iron had risen from 7.81±0.849 to 9.88±0.760 gm/dl which was more than those treated with oral iron (p<0.01); although by 6 weeks, there was no significant difference between the two groups. Ferritin levels rose rapidly in those treated with intravenous iron and remained significantly higher than in those treated with oral iron (p<0.01).Conclusions: Intravenous iron sucrose increases the hemoglobin level more rapidly than oral ferrous sulphate in women with postpartum IDA. It also replenishes iron stores more rapidly.

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Evaluation of safety and efficacy of intravenous iron sucrose therapy for moderate anaemia in antenatal women

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20194267 ◽

2019 ◽

Vol 8 (10) ◽

pp. 2258

Author(s):

K. P. Poojitha ◽

B. S. B. Mallika ◽

K. V. Siva Prasad

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anaemia ◽

Haemoglobin Concentration ◽

Intravenous Iron ◽

Iron Sucrose ◽

Efficacy And Safety ◽

Deficiency Anaemia ◽

Anaemia In Pregnancy ◽

Moderate Anaemia ◽

In Pregnancy

Background: Prevalence of iron deficiency anaemia is high in developing countries like India. Treatment of iron deficiency anaemia in pregnancy is very important to bring down maternal mortality rate as blood loss during delivery can lead to death of the patient. The aim and objective of our study is to evaluate the efficacy and safety of intravenous iron sucrose infusions in antenatal women admitted in hospital suffering from moderate iron deficiency anaemia. Special emphasis was given to observe adverse drug effects.Methods: This was a prospective observational study conducted in Obstetrics and Gynaecology department, Government General Hospital, Rangaraya Medical College, Kakinada, Andhra Pradesh. Study period was two months and study population included antenatal women with gestational age less than 37 weeks with moderate iron deficiency anaemia. Peripheral smear was examined for microcytic hypochromic anaemia and they were treated with intravenous infusion of iron sucrose. Haemoglobin levels were checked before and 5 weeks after iron infusions. Monitoring was done for adverse reactions.Results: Out of 322 admissions, 95% were found to be anaemic. 72 patients were suffering from moderate anaemia from which 25 have been included and treated with intravenous iron sucrose infusions. They were observed for efficacy and safety parameters. Two minor adverse events were reported (fever with chills and angioedema of lips) and they were excluded from study. Mean haemoglobin concentration was found to be raised from 7.08±0.73 (SD) to 11.33±0.48 (SD) within 5 weeks for 23 patients.Conclusions: Iron sucrose infusion is safe and effective for anaemia in pregnancy.

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