scholarly journals Pharmacological characterization of serotonin receptor-mediated contraction in isolated guinea-pig bronchial smooth muscle.

1993 ◽  
Vol 61 ◽  
pp. 313
Author(s):  
Yasim Kizawa ◽  
Maki Sugahara ◽  
Hiroshi Suzuki ◽  
Junko Nakano ◽  
Hajime Murakami
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Serotonin Receptor ◽  
Bronchial Smooth Muscle ◽  
Pharmacological Characterization

Morphological and Pharmacological Characterization of Guinea-Pig Prostatic Smooth Muscle Cells in Vitro

1997 ◽  
Vol 4 (2) ◽  
pp. 186-190 ◽  
Author(s):  
Naohito Mikuma ◽  
Seiji Furuya ◽  
Hiroshi Isomura ◽  
Hideo Yabu ◽  
Norimasa Sawada ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Pharmacological Characterization

scholarly journals Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries

2001 ◽  
Vol 280 (6) ◽  
pp. L1359-L1369 ◽  
Author(s):  
Karen B. Jourdan ◽  
Nicola A. Mason ◽  
Lu Long ◽  
Peter G. Philips ◽  
Martin R. Wilkins ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Adenylyl Cyclase ◽  
Pulmonary Arteries ◽  
Bronchial Epithelium ◽  
Rt Pcr ◽  
Bronchial Smooth Muscle ◽  
Functional Studies ◽  
Kinase C ◽  
Rat Lungs

Activation of adenylyl cyclase (AC), of which there are 10 diversely regulated isoforms, is important in regulating pulmonary vascular tone and remodeling. Immunohistochemistry in rat lungs demonstrated that AC2, AC3, and AC5/6 predominated in vascular and bronchial smooth muscle. Isoforms 1, 4, 7, and 8 localized to the bronchial epithelium. Exposure of animals to hypoxia did not change the pattern of isoform expression. RT-PCR confirmed mRNA expression of AC2, AC3, AC5, and AC6 and demonstrated AC7 and AC8 transcripts in smooth muscle. Western blotting confirmed the presence of AC2, AC3, and AC5/6 proteins. Functional studies provided evidence of cAMP regulation by Ca2+ and protein kinase C-activated but not Gi-inhibited pathways, supporting a role for AC2 and a Ca2+-stimulated isoform, AC8. However, NKH-477, an AC5-selective activator, was more potent than forskolin in elevating cAMP and inhibiting serum-stimulated [3H]thymidine incorporation, supporting the presence of AC5. These studies demonstrate differential expression of AC isoforms in rat lungs and provide evidence that AC2, AC5, and AC8 are functionally important in cAMP regulation and growth pathways in pulmonary artery myocytes.

scholarly journals Pharmacological characterization of the relaxant effect induced by adrenomedullin in rat cavernosal smooth muscle

2014 ◽  
Vol 47 (10) ◽  
pp. 876-885
Author(s):  
L.N. Leite ◽  
N.A. Gonzaga ◽  
D.P.C. Tirapelli ◽  
L.F. Tirapelli ◽  
C.R. Tirapelli
Keyword(s):  
Smooth Muscle ◽  
Pharmacological Characterization ◽  
Relaxant Effect
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