scholarly journals AT786→C MUTATION IN THE 5’FLANKING REGION OF THE ENDOTHELIAL NITRIC OXIDE GENE REDUCED TRANSCRIPTIONAL ACTIVITY

1997 ◽  
Vol 75 ◽  
pp. 28
Author(s):  
Masafumi Nakayama ◽  
Hirofumi Yasue ◽  
Michihiro Yoshimura ◽  
Yukio Shimasaki ◽  
Kiyotaka Kugiyama ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Transcriptional Activity ◽  
Flanking Region ◽  
Endothelial Nitric Oxide

A T-786→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene and coronary arterial vasomotility

2000 ◽  
Vol 85 (6) ◽  
pp. 710-714 ◽  
Author(s):  
Michihiro Yoshimura ◽  
Masafumi Nakayama ◽  
Yukio Shimasaki ◽  
Hisao Ogawa ◽  
Kiyotaka Kugiyama ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Flanking Region ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals T −786 →C Mutation in the 5′-Flanking Region of the Endothelial Nitric Oxide Synthase Gene Is Associated With Coronary Spasm

Circulation ◽  
1999 ◽  
Vol 99 (22) ◽  
pp. 2864-2870 ◽  
Author(s):  
Masafumi Nakayama ◽  
Hirofumi Yasue ◽  
Michihiro Yoshimura ◽  
Yukio Shimasaki ◽  
Kiyotaka Kugiyama ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Coronary Spasm ◽  
Flanking Region ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Lack of Association between T-786.RAR.C Mutation in the 5'-Flanking Region of the Endothelial Nitric Oxide Synthase Gene and Essential Hypertension.

2000 ◽  
Vol 23 (6) ◽  
pp. 561-565 ◽  
Author(s):  
Noboru KAJIYAMA ◽  
Yoshihiko SAITO ◽  
Yoshihiro MIYAMOTO ◽  
Michihiro YOSHIMURA ◽  
Masafumi NAKAYAMA ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Essential Hypertension ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Flanking Region ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

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