scholarly journals Qualitatively different effect of methylene blue administered from intimai and adventitial surface in isolated rabbit aorta

1988 ◽  
Vol 46 ◽  
pp. 185
Author(s):  
Hironori Nakanishi ◽  
Isao Matsuoka ◽  
Tomoyuki Ono ◽  
Norimichi Nakahata
2001 ◽  
Vol 47 (2) ◽  
pp. 63-73 ◽  
Author(s):  
HIRONORI NAKANISHI ◽  
ISAO MATSUOKA ◽  
TOMOYUKI ONO ◽  
SATOKO OHKUBO ◽  
NORIMICHI NAKAHATA

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Khalid Hussain Janbaz ◽  
Muhammad Farhaj Latif ◽  
Fatima Saqib ◽  
Imran Imran ◽  
M. Zia-Ul-Haq ◽  
...  

Lactuca serriolaL. has traditionally been used in folkloric medicine to manage respiratory, gastrointestinal, and multiple other ailments. The present study was undertaken to explore the effect of methanol extract ofL. serriolaon isolated rabbit tissue preparations, that is, jejunum, trachea, and aorta in an attempt to validate its folkloric use in traditional medicine for gastrointestinal, respiratory, and vascular ailments. The application of the methanol extract to isolated rabbit jejunum preparations exhibited concentration-dependent spasmogenic effect (0.03 to 3.0 mg/mL), but interestingly further increase in concentration (5.0 mg/mL) resulted in complete spasmolytic effect. The pretreatment of the tissue preparations with atropine (0.1 μM) caused the suppression of the contractile response. Moreover, the same extract also caused relaxation of K+-(80 mM) induced spastic contractions of isolated rabbit jejunum preparations (5.0 mg/mL) and shifted the Ca++dose response curves towards right at concentration range of 0.3–1.0 mg/mL. Similarly, the extract application to isolated rabbit tracheal preparations relaxed the carbachol-(1 μM) induced (0.3–1.0 mg/mL) as well as K+-(80 mM) induced contractions (3.0 mg/mL). Furthermore, it relaxed the phenylephrine (1 μM)-induced contractions in isolated rabbit aorta preparations (3.0 mg/mL) and K+(80 mM)-induced contractions (1.0 mg/mL). These effects were found comparable to that of dicyclomine, as an antagonist of muscarinic receptors as well as a possible Ca++channel blocker. The previously mentioned findings may partially justify the folkloric use ofLactuca serriolain the management of conditions pertaining to spasm of intestine, bronchioles, and vasculature.


1982 ◽  
Vol 84 (3-4) ◽  
pp. 233-235 ◽  
Author(s):  
C. Cauvin ◽  
R. Loutzenhiser ◽  
O. Hwang ◽  
C. Van Breemen

1992 ◽  
Vol 220 (2-3) ◽  
pp. 131-140 ◽  
Author(s):  
Harvey L. Wiener ◽  
Jacinta M. Murray ◽  
George P. Thalody ◽  
Saul Maayani

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