Effects of chemical modification of antibodies on their clearance from the circulation. Addition of simple aliphatic compounds by reductive alkylation and carbodiimide-promoted amide formation.

A lipodisaccharide possessing a reactive aldopentose unit, 6-O-octyl-β-D-galactopyranosyl-(1 → 5)-L-arabinose 6, was obtained by glycoside synthesis. To avoid a possible intramolecular acyl transfer, benzoyl protecting groups and mild conditions of detritylation were used in the preparation of the furanosyl acceptor. The reductive alkylation of Nα-Z-L-lysine was then studied and compared to that of previously prepared liposaccharides. In this reaction, amphiphilic five-membered hemiacetals are generally more reactive than their six-membered analogues. The newly prepared disaccharide is the most reactive of the series and also the easiest to prepare. Therefore this reagent has been selected for a future study on the chemical modification of enzymes and the use in organic solvents of the biocatalysts obtained. Keywords: liposaccharides, reductive alkylation.

Download Full-text

Chemical modification of DNA with muta-carcinogens. III. Reductive alkylation of DNA with mitomycin C.

Environmental Health Perspectives ◽

10.1289/ehp.8562219 ◽

1985 ◽

Vol 62 ◽

pp. 219-222 ◽

Cited By ~ 9

Author(s):

Y Hashimoto ◽

K Shudo

Keyword(s):

Chemical Modification ◽

Mitomycin C ◽

Reductive Alkylation

Download Full-text

Stereospecific substituted alkene synthesis by organo lithium reductive alkylation of epoxides

Tetrahedron Letters ◽

10.1016/s0040-4039(00)78391-2 ◽

1994 ◽

Vol 35 (41) ◽

pp. 7943-7946 ◽

Cited By ~ 11

Author(s):

E Doris

Keyword(s):

Reductive Alkylation ◽

Alkene Synthesis

Download Full-text

Photoconductivity in Vacuum Deposited Films of Silicon-Based Polymers

MRS Proceedings ◽

10.1557/proc-444-191 ◽

1996 ◽

Vol 444 ◽

Author(s):

H. Okumoto ◽

M. Shimomura ◽

N. Minami ◽

Y. Tanabe

Keyword(s):

Charge Transfer ◽

Chemical Modification ◽

Electronic Transport ◽

Hole Transport ◽

Electron Acceptors ◽

Oxygen Atmosphere ◽

Dangling Bonds ◽

Silicon Based ◽

Deposited Films

AbstractSilicon-based polymers with σconjugated electrons have specific properties; photoreactivity for microlithography and photoconductivity for hole transport materials. To explore the possibility of combining these two properties to develop photoresists with electronic transport capability, photoconductivity of polysilanes is investigated in connection with their photoinduced chemical modification. Increase in photocurrent is observed accompanying photoreaction of poly(dimethylsilane) vacuum deposited films. This increase is found to be greatly enhanced in oxygen atmosphere. Such changes of photocurrent can be explained by charge transfer to electron acceptors from Si dangling bonds postulated to be formed during photoreaction.

Download Full-text