scholarly journals A mutation in the human apolipoprotein A-I gene. Dominant effect on the level and characteristics of plasma high density lipoproteins

1991 ◽  
Vol 266 (21) ◽  
pp. 13654-13660
Author(s):  
S.S. Deeb ◽  
M.C. Cheung ◽  
R.L. Peng ◽  
A.C. Wolf ◽  
R. Stern ◽  
...  
Keyword(s):  
High Density ◽  
High Density Lipoproteins ◽  
Dominant Effect ◽  
Human Apolipoprotein ◽  
Apolipoprotein A ◽  
Plasma High Density ◽  
I Gene

Effect of human apolipoprotein A-I gene on vasoactive properties of high density lipoproteins in rats of different age

1998 ◽  
Vol 125 (5) ◽  
pp. 447-449
Author(s):  
V. V. Frol'kis ◽  
V. A. Kordyum ◽  
O. K. Kul'chitskii ◽  
S. N. Novikova ◽  
N. V. Sykalo ◽  
...  
Keyword(s):  
High Density ◽  
High Density Lipoproteins ◽  
Human Apolipoprotein ◽  
Apolipoprotein A ◽  
I Gene

scholarly journals Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.

1992 ◽  
Vol 267 (30) ◽  
pp. 21630-21636 ◽  
Author(s):  
J.R. Schultz ◽  
E.L. Gong ◽  
M.R. McCall ◽  
A.V. Nichols ◽  
S.M. Clift ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
High Density ◽  
High Density Lipoproteins ◽  
Human Apolipoprotein ◽  
Apolipoprotein A

scholarly journals Human apolipoprotein A-I kinetics within triglyceride-rich lipoproteins and high density lipoproteins

1999 ◽  
Vol 40 (9) ◽  
pp. 1695-1700 ◽  
Author(s):  
Wanda Vélez-Carrasco ◽  
Alice H. Lichtenstein ◽  
P. Hugh R. Barrett ◽  
Zhiyong Sun ◽  
Gregory G. Dolnikowski ◽  
...  
Keyword(s):  
High Density ◽  
High Density Lipoproteins ◽  
Human Apolipoprotein ◽  
Apolipoprotein A

scholarly journals Disruption of Human Plasma High-Density Lipoproteins by Streptococcal Serum Opacity Factor Requires Labile Apolipoprotein A-I†

Biochemistry ◽  
2009 ◽  
Vol 48 (7) ◽  
pp. 1481-1487 ◽  
Author(s):  
Mikyung Han ◽  
Baiba K. Gillard ◽  
Harry S. Courtney ◽  
Kathryn Ward ◽  
Corina Rosales ◽  
...  
Keyword(s):  
Human Plasma ◽  
High Density ◽  
High Density Lipoproteins ◽  
Apolipoprotein A ◽  
Serum Opacity Factor ◽  
Plasma High Density

Human apolipoprotein A-I: structure determination and analysis of unusual diffraction characteristics

1999 ◽  
Vol 55 (12) ◽  
pp. 2013-2021 ◽  
Author(s):  
David W. Borhani ◽  
Jeffrey A. Engler ◽  
Christie G. Brouillette
Keyword(s):  
Structure Determination ◽  
Density Lipoprotein ◽  
High Density ◽  
High Density Lipoproteins ◽  
Major Protein ◽  
Data Set ◽  
Cholesterol Acyl Transferase ◽  
Cell Parameters ◽  
Human Apolipoprotein ◽  
Apolipoprotein A

The crystallization and structure determination of recombinant human apolipoprotein A-I (apo A-I), the major protein component of high-density lipoprotein, is described. The fragment crystallized, residues 44–243 of native apo A-I [apo Δ(1–43)A-I], is very similar to intact native apo A-I in its ability to bind lipid, to be incorporated into high-density lipoproteins and to activate lecithin–cholesterol acyl transferase. Apo Δ(1–43)A-I crystallizes from 1.0–1.4 M sodium citrate pH 6.5–7.5 in space group P212121, with unit-cell parameters a = 97.47, b = 113.87, c = 196.19 Å (crystal form I). The crystals exhibit unusual diffraction intensity spikes and axial extinctions that are discussed in the context of the 4 Å crystal structure. When flash-cooled to 100 K, the crystals diffract synchrotron radiation to 3 Å resolution. Radiation sensitivity and crystal-to-crystal variation have hindered the assembly of a complete 3 Å data set.

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