Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262.

S.E. Pedersen; S.D. Sharp; W.S. Liu; J.B. Cohen

doi:10.1016/s0021-9258(19)50044-8

Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)50044-8 ◽

1992 ◽

Vol 267 (15) ◽

pp. 10489-10499

Author(s):

S.E. Pedersen ◽

S.D. Sharp ◽

W.S. Liu ◽

J.B. Cohen

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Alpha Subunit ◽

Nicotinic Acetylcholine ◽

Antagonist Binding

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Examining the Noncompetitive Antagonist-binding Site in the Ion Channel of the Nicotinic Acetylcholine Receptor in the Resting State

Journal of Biological Chemistry ◽

10.1074/jbc.275.5.3469 ◽

2000 ◽

Vol 275 (5) ◽

pp. 3469-3478 ◽

Cited By ~ 14

Author(s):

Michael P. Blanton ◽

Elizabeth A. McCardy ◽

Martin J. Gallagher

Keyword(s):

Ion Channel ◽

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Resting State ◽

Nicotinic Acetylcholine ◽

Antagonist Binding

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Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. A negatively charged region of the delta subunit within 0.9 nm of the alpha subunit binding site disulfide.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)54614-7 ◽

1991 ◽

Vol 266 (33) ◽

pp. 22603-22612

Author(s):

C. Czajkowski ◽

A. Karlin

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Alpha Subunit ◽

Agonist Binding ◽

Nicotinic Acetylcholine ◽

Delta Subunit

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Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)54504-x ◽

1991 ◽

Vol 266 (34) ◽

pp. 23354-23364

Author(s):

J.B. Cohen ◽

S.D. Sharp ◽

W.S. Liu

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Cation Binding ◽

Agonist Binding ◽

Nicotinic Acetylcholine

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Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)38551-5 ◽

1990 ◽

Vol 265 (19) ◽

pp. 11017-11029 ◽

Cited By ~ 1

Author(s):

M DiPaola ◽

P N Kao ◽

A Karlin

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Active State ◽

Alpha Subunit ◽

Nicotinic Acetylcholine ◽

Noncompetitive Inhibitor

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Expression of the alpha-bungarotoxin binding site of the nicotinic acetylcholine receptor by Escherichia coli transformants.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.84.12.4318 ◽

1987 ◽

Vol 84 (12) ◽

pp. 4318-4321 ◽

Cited By ~ 44

Author(s):

J. M. Gershoni

Keyword(s):

Escherichia Coli ◽

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Alpha Bungarotoxin

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Probing the Agonist Domain of the Nicotinic Acetylcholine Receptor by Cysteine Scanning Mutagenesis Reveals Residues in Proximity to the α-Bungarotoxin Binding Site†

Biochemistry ◽

10.1021/bi982656z ◽

1999 ◽

Vol 38 (16) ◽

pp. 4912-4921 ◽

Cited By ~ 18

Author(s):

Armin Spura ◽

Tanya S. Russin ◽

Neal D. Freedman ◽

Marianne Grant ◽

James T. McLaughlin ◽

...

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Cysteine Scanning ◽

Cysteine Scanning Mutagenesis

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An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein

Journal of Biological Chemistry ◽

10.1074/jbc.m117.815316 ◽

2017 ◽

Vol 293 (7) ◽

pp. 2534-2545 ◽

Cited By ~ 15

Author(s):

Florian Delbart ◽

Marijke Brams ◽

Fabian Gruss ◽

Sam Noppen ◽

Steve Peigneur ◽

...

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Protein ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Acetylcholine Binding Protein

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A Transmembrane Binding Site at a Subunit Interface for Torpedo Nicotinic Acetylcholine Receptor Potentiators And Inhibitors

Biophysical Journal ◽

10.1016/j.bpj.2009.12.708 ◽

2010 ◽

Vol 98 (3) ◽

pp. 131a

Author(s):

Ayman K. Hamouda ◽

Deidre Stewart ◽

S. Shaukat Husain ◽

Jonathan B. Cohen

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Subunit Interface ◽

A Subunit

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Sequence and functional expression of a single alpha subunit of an insect nicotinic acetylcholine receptor.

The EMBO Journal ◽

10.1002/j.1460-2075.1990.tb07889.x ◽

1990 ◽

Vol 9 (13) ◽

pp. 4391-4398 ◽

Cited By ~ 105

Author(s):

J. Marshall ◽

S. D. Buckingham ◽

R. Shingai ◽

G. G. Lunt ◽

M. W. Goosey ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Functional Expression ◽

Alpha Subunit ◽

Nicotinic Acetylcholine

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A Common Binding Site for Channel-Permeant Cations and Local Anesthetics on the Nicotinic Acetylcholine Receptor

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1991.tb33898.x ◽

1991 ◽

Vol 625 (1 Molecular and) ◽

pp. 645-648

Author(s):

JEFFREY M. HERZ ◽

STEPHEN KOLB ◽

THOMAS ERLINGER

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Local Anesthetics ◽

Nicotinic Acetylcholine

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