scholarly journals Tumor angiogenic factor. Purification from the Walker 256 rat tumor.

1981 ◽  
Vol 256 (18) ◽  
pp. 9605-9611
Author(s):  
A. Fenselau ◽  
S. Watt ◽  
R.J. Mello
Keyword(s):  
Angiogenic Factor ◽  
Walker 256 ◽  
Rat Tumor ◽  
Tumor Angiogenic Factor

Assessment of Anti-Angiogenic Drug in Cancer Therapy

2012 ◽  
pp. 236-246
Author(s):  
Indrajit Pan
Keyword(s):  
Endothelial Cells ◽  
Cancer Therapy ◽  
Blood Vessels ◽  
Initial Phase ◽  
Quantitative Assessment ◽  
Angiogenic Factor ◽  
Cellular Space ◽  
Two Factors ◽  
Analytical Assessment ◽  
Tumor Angiogenic Factor

It has been documented in the literature that a solid tumor survives by the generation of micro-vessels around it. This phenomenon is known as angiogenesis. Angiogenesis is governed by two factors, namely Tumor Angiogenic Factor (TAF) secreted by the tumor cells and tissue Fibronectin (FNT) concentration in the extra-cellular space. These two factors help in mobilization of endothelial cells from nearby blood vessels. At the initial phase of angiogenesis, neighboring blood vessels affect in formation of capillary sprouts. In this work, to the authors develop a clinically relevant analytical model that could act as an effective tracing system of tumor growth. The author has performed a quantitative assessment of tumor angiogenesis. This analytical method is a correlation between tumor system and vasculature system through an analytical assessment at peripheral blood circulatory of tumor milieu.

STUDIES ON THE TRANSPLANTATION OF A RAT TUMOR TO MICE

1957 ◽  
Vol 35 (1) ◽  
pp. 923-928
Author(s):  
A. Cameron Wallace ◽  
Susan Davis
Keyword(s):  
Tissue Culture ◽  
Mouse Brain ◽  
Serial Passage ◽  
Selective Adaptation ◽  
Growth And Survival ◽  
Heterologous Transplantation ◽  
Walker 256 ◽  
Foreign Species ◽  
Rat Tumor

The growth and survival of Walker 256 rat tumor grafted direct from rat into mouse thigh was compared with that of the same tumor after long continued residence in mouse brain, and also with that of tumors cultivated for a prolonged period in vitro. It was found that the pattern of growth and regression with tumor grown for 8 months in tissue culture was identical with that produced with tumor direct from rats. Tumor previously grown for 30 generations in mouse brain showed poorer growth and earlier regression. Since both prolonged growth in vitro and serial passage in mouse brain should have removed all the original rat stroma, it is concluded that loss of foreign stroma does not appreciably affect heterologous transplantation. Similarly, prolonged growth of this tumor in a foreign species under the conditions outlined apparently fails to produce any selective adaptation of the tumor to the host.

The novel tumor angiogenic factor, adrenomedullin-2, predicts survival in pancreatic adenocarcinoma

2015 ◽  
Vol 197 (2) ◽  
pp. 219-224 ◽  
Author(s):  
Lindsay L. Hollander ◽  
Xiaojia Guo ◽  
Ronald R. Salem ◽  
Charles H. Cha
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Angiogenic Factor ◽  
The Novel ◽  
Tumor Angiogenic Factor

Response of intramuscular walker 256 rat tumor to sustained-release cyclophosphamide and ara-c capsules

1978 ◽  
Vol 10 (2) ◽  
pp. 133-140 ◽  
Author(s):  
J. C. Fu ◽  
D. L. Moyer ◽  
J. Cuevas ◽  
L. Cummings ◽  
A. Eaton ◽  
...  
Keyword(s):  
Sustained Release ◽  
Walker 256 ◽  
Rat Tumor

STUDIES ON THE TRANSPLANTATION OF A RAT TUMOR TO MICE

1957 ◽  
Vol 35 (11) ◽  
pp. 923-928
Author(s):  
A. Cameron Wallace ◽  
Susan Davis
Keyword(s):  
Tissue Culture ◽  
Mouse Brain ◽  
Serial Passage ◽  
Selective Adaptation ◽  
Growth And Survival ◽  
Heterologous Transplantation ◽  
Walker 256 ◽  
Foreign Species ◽  
Rat Tumor

The growth and survival of Walker 256 rat tumor grafted direct from rat into mouse thigh was compared with that of the same tumor after long continued residence in mouse brain, and also with that of tumors cultivated for a prolonged period in vitro. It was found that the pattern of growth and regression with tumor grown for 8 months in tissue culture was identical with that produced with tumor direct from rats. Tumor previously grown for 30 generations in mouse brain showed poorer growth and earlier regression. Since both prolonged growth in vitro and serial passage in mouse brain should have removed all the original rat stroma, it is concluded that loss of foreign stroma does not appreciably affect heterologous transplantation. Similarly, prolonged growth of this tumor in a foreign species under the conditions outlined apparently fails to produce any selective adaptation of the tumor to the host.

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