Assessment of Anti-Angiogenic Drug in Cancer Therapy

It has been documented in the literature that a solid tumor survives by the generation of micro-vessels around it. This phenomenon is known as angiogenesis. Angiogenesis is governed by two factors, namely Tumor Angiogenic Factor (TAF) secreted by the tumor cells and tissue Fibronectin (FNT) concentration in the extra-cellular space. These two factors help in mobilization of endothelial cells from nearby blood vessels. At the initial phase of angiogenesis, neighboring blood vessels affect in formation of capillary sprouts. In this work, to the authors develop a clinically relevant analytical model that could act as an effective tracing system of tumor growth. The author has performed a quantitative assessment of tumor angiogenesis. This analytical method is a correlation between tumor system and vasculature system through an analytical assessment at peripheral blood circulatory of tumor milieu.

TUMOR ANGIOGENESIS BASED ANALYTICAL MODEL FOR THE ASSESSMENT OF MCT AND MTD CHEMOTHERAPEUTIC STRATEGIES IN CANCER

Solid tumor survives by the process of angiogenesis. In this process micro-vessels are generated around it. Two factors govern this process. One is Tumor Angiogenic Factor (TAF) secreted by the tumor cells and another is tissue Fibronectin (FNT) concentration in the extra-cellular space. These two factors help in mobilization of endothelial cells from nearby blood vessels, a process called angiogenesis. Metronomic chemotherapeutic (MCT) procedure is targeted at this angiogenic microvessels at the cancer milieu and thereby, limits the growth of cancer cells. Here, we have developed a fluid dynamical based analytical model. The model comprises tumor system and a microvasculature system around it. Another characteristic of the developed model is the incorporation of a tracking procedure of either the tumor or microvasculature system from the peripheral blood. Therefore, this analytical method makes a correlation between tumor system, its micro-vasculature system and the peripheral blood circulatory system. With this analytical armamentarium we have tested the effectiveness of MCT in comparison with the conventional maximum tolerable dosing (MTD) strategy. Our simulation result reveals that under the condition MCT is better compared to MTD in controlling tumor growth in a dynamical sense. The advantage of this analytical model is that the tumor system dynamics can be effectively traced through both invasive and non-invasive procedure as and when required.

Assessment of Anti-angiogenic Drug in Cancer Therapy

It has been documented in the literature that a solid tumor survives by the generation of micro-vessels around it. This phenomenon is known as angiogenesis. Angiogenesis is governed by two factors, namely Tumor Angiogenic Factor (TAF) secreted by the tumor cells and tissue Fibronectin (FNT) concentration in the extra-cellular space. These two factors help in mobilization of endothelial cells from nearby blood vessels. At the initial phase of angiogenesis, neighboring blood vessels affect in formation of capillary sprouts. In this work, to the authors develop a clinically relevant analytical model that could act as an effective tracing system of tumor growth. The author has performed a quantitative assessment of tumor angiogenesis. This analytical method is a correlation between tumor system and vasculature system through an analytical assessment at peripheral blood circulatory of tumor milieu.