scholarly journals A comparison of 13C nuclear magnetic resonance and 14C tracer studies of hepatic metabolism.

1981 ◽  
Vol 256 (7) ◽  
pp. 3428-3432
Author(s):  
S.M. Cohen ◽  
R. Rognstad ◽  
R.G. Shulman ◽  
J. Katz
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Hepatic Metabolism ◽  
Tracer Studies ◽  
13C Nuclear Magnetic Resonance ◽  
Nuclear Magnetic

13C Nuclear Magnetic Resonance and 14C Tracer Studies on 1,2-Phenyl Shifts in the Reaction of Labeled Triphenylvinyl Bromide with Acetic Acid and Silver Acetate

1975 ◽  
Vol 53 (3) ◽  
pp. 314-319 ◽  
Author(s):  
Franz H. A. Rummens ◽  
Robert D. Green ◽  
Allan J. Cessna ◽  
Mitsuo Oka ◽  
Choi Chuck Lee
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Acetic Acid ◽  
Magnetic Resonance ◽  
Reasonable Agreement ◽  
Silver Acetate ◽  
Tracer Method ◽  
Tracer Studies ◽  
13C Nuclear Magnetic Resonance ◽  
Specific Activities ◽  
Nuclear Magnetic

Reaction of triphenylvinyl bromide, labeled at C-2 with 14C or 13C (1—Br-2-14C or 1—Br-2-l3C), with HOAc–AgOAc gave an isotopically rearranged product, 1—OAc-x-14C or 1—OAc-x-13C. After conversion of the product to 1,2,2-triphenylethanol (2—x-14C or 2—x-13C), 14C assays after degradation to benzophenone, or analyses by FT c.m.r. and by 13C satellites of p.m.r. in the FT or CW mode all gave results that were in reasonable agreement, indicating 6.8 ± 0.9% scrambling of the label from C-2 to C-1. The work shows that while the c.m.r. technique eliminates the need for degradation, the tracer method, with appropriately high specific activities, is capable of giving higher precision.

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