Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine of cyclosporin A. Identification of 3(R)-hydroxy-4(R)-methyl-6(E)-octenoic acid as a key intermediate by enzymatic in vitro synthesis and by in vivo labeling techniques.
1993 ◽
Vol 268
(35)
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pp. 26127-26134
1987 ◽
Vol 52
(9)
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pp. 2317-2325
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1995 ◽
Vol 60
(7)
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pp. 1229-1235
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1983 ◽
Vol 258
(20)
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pp. 12587-12593
2004 ◽
Vol 76
(6)
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pp. 519-527
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1984 ◽
Vol 247
(5)
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pp. E639-E644
1964 ◽
Vol 93
(1)
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pp. 150-157
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2004 ◽
Vol 75
(3)
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pp. 380-387
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