Cardiac abnormalities in a female patient with hypogonadotropic hypogonadism with anosmia

An acute episode of symptomatic sinus bradycardia, occurred in a 50-year-old female patient after she had been given a single therapeutic dose of mianserin. Heart rate was corrected by atropine injection. Re-administration of mianserin resulted in the recurrence of bradycardia. Further examination showed no cardiac abnormalities. This case is the first report of conduction defect in a patient given therapeutic doses of mianserin.

Download Full-text

Cardiac abnormalities in female hypogonadotropic hypogonadism with anosmia

American Journal of Obstetrics and Gynecology ◽

10.1016/0002-9378(80)91062-5 ◽

1980 ◽

Vol 136 (7) ◽

pp. 964-966 ◽

Cited By ~ 4

Author(s):

Ekkehard Kemmann ◽

Patricia Conrad ◽

James R. Jones

Keyword(s):

Hypogonadotropic Hypogonadism ◽

Cardiac Abnormalities

Download Full-text

Anesthetic Management of a Patient with Fontan Physiology for Laparoscopic Cholecystectomy

Nepalese Heart Journal ◽

10.3126/njh.v17i2.32681 ◽

2020 ◽

Vol 17 (2) ◽

pp. 51-53

Author(s):

Santosh Sharma Parajuli

Keyword(s):

Laparoscopic Cholecystectomy ◽

Survival Rate ◽

General Anesthesia ◽

Female Patient ◽

Anesthetic Management ◽

Surgical Techniques ◽

Medical Sciences ◽

Cardiac Abnormalities ◽

Fontan Physiology ◽

Fontan Palliation

With the modification in surgical techniques and advancement in medical sciences, the survival rate of patients with complex cardiac abnormalities has increased to more than 90% in about 10 years after Fontan palliation. These patients can present with some form of non-cardiac surgeries during their lifetime. Better understanding of Fontan physiology can help in proper perioperative anesthetic management of these patients. Our cases was of a 17-year-old female patient with Fontan physiology for her Ebstein's Anomaly, planned for Laparoscopic Cholecystectomy under general anesthesia. Here we describe how we successfully managed the case perioperatively.

Download Full-text

Hypogonadotropic hypogonadism in a female patient with congenital arhinia

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2016-0082 ◽

2017 ◽

Vol 30 (1) ◽

Cited By ~ 4

Author(s):

Janel Darcy Hunter ◽

Melissa Ann Davis ◽

Jennifer Rachel Law

Keyword(s):

Female Patient ◽

Hypogonadotropic Hypogonadism ◽

Brain Magnetic Resonance Imaging ◽

Abdominal Ultrasound ◽

Sex Steroid ◽

Laboratory Evaluation ◽

Delayed Puberty ◽

Timely Initiation ◽

Normal Pituitary Gland ◽

First Case

AbstractThe association of anosmia and congenital hypogonadotropic hypogonadism (CHH) is well described; however, congenital arhinia is a malformation associated with CHH that occurs much more rarely. There have been three reports of male patients with hypogonadism and congenital arhinia in the literature to date. We present the first case of arhinia associated with CHH in a female patient. A 14 years and 8 months female with congenital arhinia presented with delayed puberty. Physical examination and laboratory evaluation were consistent with hypogonadotropic hypogonadism. She had no other hormone deficiencies and brain magnetic resonance imaging demonstrated a normal pituitary gland. Abdominal ultrasound showed a prepubertal uterus and ovaries. She was subsequently started on sex steroid treatment to induce secondary sexual characteristics. This case demonstrates that abnormalities of nasal development may provide an early diagnostic clue to hypogonadotropic hypogonadism, particularly in female patients who would not manifest classic signs of CHH in infancy (micropenis and cryptorchidism). Early diagnosis of CHH and timely initiation of sex steroid therapy is important to prevent comorbidities related to pubertal delay.

Download Full-text