Mitochondrial respiration following acute hypoxia in the perfused rat heart

1985 ◽  
Vol 17 (1) ◽  
pp. 71-81 ◽  
Author(s):  
E.O. Fuller ◽  
D.I. Goldberg ◽  
J.W. Starnes ◽  
L.M. Sacks ◽  
M. Delivoria-Papadopoulos
Keyword(s):  
Mitochondrial Respiration ◽  
Rat Heart ◽  
Acute Hypoxia ◽  
Perfused Rat Heart

scholarly journals Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart

2009 ◽  
Vol 423 (3) ◽  
pp. 421-428 ◽  
Author(s):  
Bernard Korzeniewski ◽  
Véronique Deschodt-Arsac ◽  
Guillaume Calmettes ◽  
Gilles Gouspillou ◽  
Jean-Michel Franconi ◽  
...  
Keyword(s):  
Heart Rate ◽  
Oxidative Phosphorylation ◽  
Mitochondrial Respiration ◽  
Rat Heart ◽  
Supply And Demand ◽  
Rate Pressure Product ◽  
Perfused Rat Heart ◽  
Physiological Conditions ◽  
Heart Perfusion ◽  
Atp Supply

Mitochondrial respiration/oxidative phosphorylation is the main source of energy, in the form of ATP, in the heart under physiological conditions. Different respiratory substrates were used in various experiments during heart perfusion: glucose, pyruvate, lactate, glucose+pyruvate, glucose+lactate, glucose+insulin etc. Also under physiological conditions, the concentration of respiratory substrates/hormones in blood can vary significantly. In the present study, we tested the effect of pyruvate, lactate and insulin (all in the presence of glucose) and glucose (in the presence of pyruvate) on the ATP-producing and -consuming blocks in perfused rat heart, in a system where HR (heart rate) was allowed to vary (no pacing). Changes in RPP (rate-pressure product) and PCr (phosphocreatine) concentration were measured. PAA (Proportional Activation Approach) was used to visualize and quantitatively analyse the data. It was demonstrated that addition of glucose (in the presence of pyruvate) exerted essentially no effect on the system. Insulin (in the presence of glucose) activated only the ATP producer. The most interesting finding is that, in our system, pyruvate and lactate (added in the presence or instead of glucose) activated ATP producer, but significantly inhibited ATP consumer (their effect was quantitatively identical).

Continuous Adaptation of Rats to Hypobaric Hypoxia Prevents Stressor Hyperglycemia and Optimizes Mitochondrial Respiration in Acute Hypoxia

2013 ◽  
Vol 4 (2) ◽  
pp. 137-147
Author(s):  
Vladimir I. Portnichenko ◽  
Valentina I. Nosar ◽  
Alla M. Sydorenko ◽  
Alla G. Portnychenko ◽  
Irina N. Mankovska
Keyword(s):  
Mitochondrial Respiration ◽  
Hypobaric Hypoxia ◽  
Acute Hypoxia

scholarly journals Pseudoketogenesis in the perfused rat heart.

1988 ◽  
Vol 263 (34) ◽  
pp. 18036-18042 ◽  
Author(s):  
G Fink ◽  
S Desrochers ◽  
C Des Rosiers ◽  
M Garneau ◽  
F David ◽  
...  
Keyword(s):  
Rat Heart ◽  
Perfused Rat Heart
Sign in / Sign up

Export Citation Format

Share Document