Recent advances in diagnosis and treatment of gastrointestinal hemorrhage in infants and children

1985 ◽  
Vol 106 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Jeffrey S. Hyams ◽  
Alan M. Leichtner ◽  
Andrew N. Schwartz
2019 ◽  
Vol 5 (1) ◽  
pp. 11 ◽  
Author(s):  
Thomas Walsh ◽  
Aspasia Katragkou ◽  
Tempe Chen ◽  
Christine Salvatore ◽  
Emmanuel Roilides

This paper reviews recent advances in three selected areas of pediatric invasive candidiasis: epidemiology, diagnosis, and treatment. Although the epidemiological trends of pediatric invasive candidiasis illustrate a declining incidence, this infection still carries a heavy burden of mortality and morbidity that warrants a high index of clinical suspicion, the need for rapid diagnostic systems, and the early initiation of antifungal therapy. The development of non-culture-based technologies, such as the T2Candida system and (1→3)-β-d-glucan detection assay, offers the potential for early laboratory detection of candidemia and CNS candidiasis, respectively. Among the complications of disseminated candidiasis in infants and children, hematogenous disseminated Candida meningoencephalitis (HCME) is an important cause of neurological morbidity. Detection of (1→3)-β-d-glucan in cerebrospinal fluid serves as an early diagnostic indicator and an important biomarker of therapeutic response. The recently reported pharmacokinetic data of liposomal amphotericin B in children demonstrate dose–exposure relationships similar to those in adults. The recently completed randomized clinical trial of micafungin versus deoxycholate amphotericin B in the treatment of neonatal candidemia provides further safety data for an echinocandin in this clinical setting.


2021 ◽  
Vol 15 (6) ◽  
Author(s):  
Mohammad Karimian ◽  
Feizollah Mansouri ◽  
Milad Borji ◽  
Asma Tarjoman ◽  
Somayeh Mahdikhani ◽  
...  

Context: Coronavirus disease 2019 (COVID-19) is one of the most dangerous viral diseases that started spreading in China in 2019 and has caused many deaths so far. Therefore, this study aimed to systematically review studies on the prevention, diagnosis, and treatment of coronavirus in infants and children. Evidence Acquisition: This is a systematic review study conducted in PubMed/Medline, Scopus, Embase, Cochrane Library, Science Direct, and Web of Science (ISI) databases on October 8 2020. Also, we searched Google Scholar to find all in-press articles. To extract data, a checklist was used, which included the author’s name, year of publication, purpose, age group of patients under study, and the protocol applied for coronavirus prevention, diagnosis, and treatment. The search was done with AND, OR, NOT strategies. The results of the study were reported in a descriptive manner using Endnote version 8 software. Results: According to the results of the basic search, 120 articles were extracted on the management of coronavirus. Of the articles extracted, 30 were articles related to children, of which only eight developed protocols for prevention, diagnosis, and treatment in infants and children. Of the studies extracted, six were from China, one from Iran, and one from Australia. It should be noted that the protocols for infants were extracted from two studies on infants and four studies on the pediatric group. Conclusions: It is proposed to consider and study this systematic review of coronavirus management in infants and children.


PEDIATRICS ◽  
1957 ◽  
Vol 19 (3) ◽  
pp. 540-540
Author(s):  
MARION B. SULZBERGER

In view of his inevitable daily encounters with skin diseases, it is axiomatic that every pediatrician should possess and know how to use at least one modern textbook devoted to dermatology; and here is a modern text written expressly for pediatricians by an experienced dermatologist. Dr. Leider has succeeded in his objective and has compressed into 433 pages a wealth of practical experience in the diagnosis and treatment of skin diseases in infants and children.


Sign in / Sign up

Export Citation Format

Share Document