Stress as a predictor of symptomatic genital herpes virus recurrence in women with human immunodeficiency virus

2003 ◽  
Vol 54 (3) ◽  
pp. 237-244 ◽  
Author(s):  
Deidre Byrnes Pereira ◽  
Michael H Antoni ◽  
Aimee Danielson ◽  
Trudi Simon ◽  
JoNell Efantis-Potter ◽  
...  
2012 ◽  
pp. 305-311 ◽  
Author(s):  
María Lilia Diaz Betancourth ◽  
Julio Cesar Klinger ◽  
Victoria Eugenia Niño

Lymphocytopenia and CD4+ T lymphocytopenia can be associated with many bacterial, fungal, parasite and viral infections. They can also be found in autoimmune and neoplastic diseases, common variable immu­nodeficiency syndrome, physical, psychological and traumatic stress, malnutrition and immunosuppressive therapy. Besides, they can also be brought into relation, without a known cause, with idiopathic CD4+ T lym­phocytopenia. Among viral infections, the Retrovirus, specially the human immunodeficiency virus, is the most frequently cause. However, many acute viral infections, including cytomegalovirus and Epstein Barr virus can be associated with transient lymphocytopenia and CD4+ T lymphocytopenia. As is well known, transient lymphocytopenia and CD4+ T lymphocytopenia are temporary and overcome when the disease improves. Nonetheless, severe CD4+ T Lymphocytopenia associated with chronic infections by human herpes virus has not been reported. We describe 6 cases of human immunodeficiency virus negative patients, with chronic cytomegalovirus and Epstein Barr virus infections and profound lymphocytopenia with clinical symptoms of cellular immunodeficiency. These patients improved rapidly with ganciclovir or valganciclovir treatment. We claim here that it is important to consider the chronic human herpes virus infection in the differential diag­nosis of profoundly CD4+ T lymphocytopenia etiology, when human immunodeficiency virus is absent, in order to start effective treatment and to determine, in future studies, the impact of chronic human herpes virus infection in human beings’ health.


2018 ◽  
Vol 7 ◽  
pp. 131
Author(s):  
Riry Febrina Ersha ◽  
Armen Ahmad

Acquired Immunodeficiency Syndrome (AIDS) adalah infeksi yang disebabkan oleh Human Immunodeficiency Virus (HIV) yang menyebabkan suatu penyakit yang menyerang sel-sel kekebalan tubuh. Sebuah temuan baru yang mengarah pada pertumbuhan, isolasi dan karakterisasi dari sebuah virus herpes baru yang dikenal dengan kaposi’s sarcoma-associated herpes virus (KSHV) atau human herpes virus type 8 (HHV-8) dari lesi sarkoma kaposi (SK). Sarkoma kaposi adalah kanker yang berkembang dari sel-sel yang melapisi kelenjar getah bening atau pembuluh darah. Seseorang yang terinfeksi HIV mempunyai risiko 100 hingga 300 kali lebih sering terkena SK. Lesi awal SK-AIDS tampak sebagai makula keunguan berbentuk oval kecil yang berkembang dengan cepat menjadi plak dan nodul kecil, yang seringkali timbul di seluruh bagian tubuh dan memiliki kecenderungan mengalami progresivitas yang cepat. Telah dilaporkan kasus seorang laki-laki imunokompromais berusia 27 tahun datang dengan keluhan lemah letih lesu dan bentol-bentol berwarna merah keunguan di dada, perut, punggung dan belakang telinga sejak 3 bulan sebelum masuk rumah sakit. Pemeriksaan lebih lanjut menunjukkan adanya HIV-AIDS dengan TB paru, candidiasis oral dan sarkoma kaposi. Diagnosis pada pasien ini ditegakkan berdasarkan keluhan dan data klinis yaitu anti HIV positif dengan CD4 49 u/L dan biopsi kulit dengan hasil sesuai dengan gambaran sarkoma kaposi. Penatalaksanaan pada pasien ini yaitu dengan pemberian OAT kategori I, ARV dan anti jamur. Pemberian ARV yang adekuat untuk HIV-AIDS merupakan kunci dalam tatalaksana SK-AIDS.


Blood ◽  
1996 ◽  
Vol 88 (8) ◽  
pp. 3124-3128 ◽  
Author(s):  
JW Said ◽  
T Tasaka ◽  
S Takeuchi ◽  
H Asou ◽  
S de Vos ◽  
...  

Recent molecular evidence suggests an association with a new herpes virus, Kaposi's sarcoma-associated herpes virus (KSHV/HHV-8), and primary effusion lymphomas (PEL). PELs have a characteristic morphology, phenotype, and clinical presentation with malignant effusions in the absence of a contiguous solid tumor mass. Most cases of PEL have occurred in human immunodeficiency virus (HIV)-positive male patients who are coinfected with Epstein-Barr virus (EBV). This report describes two cases of PEL in HIV- and EBV-negative women. In one patient, a pleural cavity PEL was preceded by classic Kaposi's Sarcoma (KS) of the lower extremities. In the second patient, PEL developed in an artificial cavity related to the capsule of a breast implant. Both cases had the characteristic morphologic appearance of high-grade anaplastic/B-cell immunoblastic lymphomas, with loss of B-cell differentiation antigens, clonal immunoglobulin heavy chain gene rearrangements, and expression of activation antigen CD30. Both cases were negative for EBV, herpes virus simplex, and cytomegalovirus (CMV). DNA extracted from both lymphomas and skin KS specimen showed KSHV sequences by molecular analysis. This report expands the spectrum of KSHV-associated disease to include PEL in HIV-negative women.


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