Radical Nephrectomy for Renal Cell Carcinoma: Long-Term Results and Prognostic Factors on a Series of 328 Cases

Abstract Background: Renal cell carcinoma (RCC) is the most common renal malignancy in adults. RCC can metastasize to various organs of the human body, including lung, bone, brain, liver, and adrenal gland. However, solitary metastases are relatively rare in clinical practice, and surgical treatment is still the preferred treatment.Case report: We present a 68-year-old male patient who was performed laparoscopic radical left nephrectomy for RCC 8 years ago. Postoperative routine examination revealed an occupying lesion in the liver. Further PET-CT suggested hepatic metastasis of RCC thus undergoing laparoscopic left hepatectomy. Pathology confirmed metastatic RCC in the liver. The patient recovered well after the operation, and there was no sign of recurrence during the follow-up for six months after the operation.Conclusion: Patients with renal carcinoma can still have recurrence and metastasis after radical nephrectomy for many years. Therefore, long-term close follow-up is beneficial to patients with radical nephrectomy.

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Long-Term Results of Nephron Sparing Surgery for Localized Renal Cell Carcinoma

Urologia Journal ◽

10.1177/039156030407100309 ◽

2004 ◽

Vol 71 (3) ◽

pp. 219-223

Author(s):

R. Autorino ◽

M. De Sio ◽

R. Damiano ◽

M. Schiavo ◽

L. Cosentino ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Nephron Sparing Surgery ◽

Long Term Results ◽

Nephron Sparing ◽

Localized Renal Cell Carcinoma

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Interferon Adjuvant to Radical Nephrectomy in Robson Stages II and III Renal Cell Carcinoma: A Multicentric Randomized Study

Journal of Clinical Oncology ◽

10.1200/jco.2001.19.2.425 ◽

2001 ◽

Vol 19 (2) ◽

pp. 425-431 ◽

Cited By ~ 195

Author(s):

Giorgio Pizzocaro ◽

Luigi Piva ◽

Maria Colavita ◽

Sonia Ferri ◽

Raffaella Artusi ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Prognostic Factors ◽

Protective Effect ◽

Cell Carcinoma ◽

Renal Cell ◽

Radical Nephrectomy ◽

Rank Test ◽

Event Free Survival ◽

Free Survival ◽

Log Rank Test

PURPOSE: Because interferon gave promising results in the management of metastatic renal cell carcinoma in the 1980s, a multicentric randomized controlled trial was planned to compare adjuvant recombinant interferon alfa-2b (rIFNα2b) with observation after radical nephrectomy in patients with Robson stages II and III renal cell carcinoma. Overall and event-free survival were to be evaluated together with prognostic factors. PATIENTS AND METHODS: Overall and event-free survival curves for 247 patients (124 controls and 123 treated) were estimated by the Kaplan-Meier method and compared using the log-rank test. Cox’s multiple regression models were adopted to perform a joint analysis of treatment and prognostic factors. RESULTS: The 5-year overall and event-free survival probabilities were 0.665 and 0.671, respectively, for controls and 0.660 and 0.567, respectively, for the treated group; the differences were not statistically significant (2P = .861 for overall and 2P = .107 for event-free survival with the log-rank test). Regarding prognostic factors, only grade, pT, and pN demonstrated a significant prognostic role. First-order interactions of treatment with pT and pN category were investigated; a significant interaction was found between pN and treatment. A harmful effect of rIFNα2b in the 97 treated pN0 patients and a protective effect in the 13 treated pN2/pN3 patients were statistically significant. CONCLUSION: Adjuvant rIFNα2b is not indicated after radical nephrectomy for renal cell carcinoma. The protective effect in the small group of pN2/pN3 patients requires further investigation.

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