THE EFFECT OF A SUBSTANCE RELEASED FROM THE MUCOSA THAT MAY ACTIVATE SPONTANEOUS CONTRACTILITY IS PRONOUNCED IN A RAT MODEL OF BLADDER OUTLET OBSTRUCTION AND INVOLVE MUSCARINIC RECEPTORS

2008 ◽  
Vol 179 (4S) ◽  
pp. 126-126
Author(s):  
Hironobu Akino ◽  
Keiko Nagase ◽  
Ippei Tanaka ◽  
Donna J Sellers ◽  
Neil McKay ◽  
...  
Keyword(s):  
Muscarinic Receptors ◽  
Rat Model ◽  
Bladder Outlet Obstruction ◽  
Outlet Obstruction

Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet Obstruction

2016 ◽  
Vol 195 (3) ◽  
pp. 780-787 ◽  
Author(s):  
Nozomu Miyazaki ◽  
Osamu Yamaguchi ◽  
Masanori Nomiya ◽  
Ken Aikawa ◽  
Junko Kimura
Keyword(s):  
Rat Model ◽  
Detrusor Overactivity ◽  
Bladder Outlet Obstruction ◽  
Outlet Obstruction ◽  
Preventive Effect ◽  
Hydrogen Water

Effects of a vitamin D3 analogue in a rat model of bladder outlet obstruction

2006 ◽  
Vol 98 (3) ◽  
pp. 637-642 ◽  
Author(s):  
ANNETTE SCHRODER ◽  
ENRICO COLLI ◽  
MARIO MAGGI ◽  
KARL-ERIK ANDERSSON
Keyword(s):  
Vitamin D3 ◽  
Rat Model ◽  
Bladder Outlet Obstruction ◽  
Outlet Obstruction

Urodynamics and bladder muscarinic receptors in rats with cerebral infarction and bladder outlet obstruction

2007 ◽  
Vol 414 (1) ◽  
pp. 80-84 ◽  
Author(s):  
Shuji Maruyama ◽  
Souhei Kurosawa ◽  
Yukiko Takagi ◽  
Tomomi Oki ◽  
Yukiko Noguchi ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Muscarinic Receptors ◽  
Bladder Outlet Obstruction ◽  
Outlet Obstruction

scholarly journals Differentially Expressed Genes Correlated with Fibrosis in a Rat Model of Chronic Partial Bladder Outlet Obstruction

Processes ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 2219
Author(s):  
Yuan-Shuo Hsueh ◽  
Hui-Hua Chang ◽  
Shun-Yao Ko ◽  
Yi-Pai Lin ◽  
Wei-Yu Lin
Keyword(s):  
Differentially Expressed Genes ◽  
Rat Model ◽  
Bladder Outlet Obstruction ◽  
Outlet Obstruction ◽  
Clinical Problem ◽  
Differentially Expressed ◽  
Partial Bladder Outlet Obstruction ◽  
Bladder Weight ◽  
Gene Expression Alterations ◽  
Tgfb Signaling

Chronic partial bladder outlet obstruction (PBOO) is a prevalent clinical problem that may result from multiple etiologies. PBOO may be a secondary condition to various anatomical and functional abnormalities. Bladder fibrosis is the worst outcome of PBOO. However, gene alterations and the mechanism of fibrosis development after PBOO onset are not clear. Therefore, we aimed to investigate gene expression alterations during chronic PBOO. A rat model of PBOO was established and validated by a significant increase in rat bladder weight. The bladder samples were further analyzed by microarray, and differentially expressed genes (DEGs) that are more related to PBOO compared with the control genes were selected. The data showed that 16 significantly upregulated mRNAs and 3 significantly downregulated mRNAs are involved in fibrosis. Moreover, 13 significantly upregulated mRNAs and 12 significantly downregulated mRNAs are related to TGFB signaling. Twenty-two significantly upregulated mRNAs and nine significantly downregulated mRNAs are related to the extracellular matrix. The genes with differential expressions greater than four-fold included Grem1, Thbs1, Col8a1, Itga5, Tnc, Lox, Timp1, Col4a1, Col4a2, Bhlhe40, Itga1, Tgfb3, and Gadd45b. The gene with a differential expression less than a quarter-fold was Thbs2. These findings show the potential roles of these genes in the physiology of PBOO.

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