The Effect of Radiation Therapy and Hyperthermia on a Human Prostatic Carcinoma Cell Line Grown in Athymic Nude Mice

1991 ◽  
Vol 145 (3) ◽  
pp. 654-656 ◽  
Author(s):  
Issac Kaver ◽  
Warren W. Koontz ◽  
John D. Wilson ◽  
John M. Guice ◽  
Joy L. Ware
2004 ◽  
Vol 210 (1) ◽  
pp. 27-33 ◽  
Author(s):  
D Martarelli ◽  
B Martarelli ◽  
D Pediconi ◽  
M.I Nabissi ◽  
M Perfumi ◽  
...  

2020 ◽  
Vol 9 ◽  
pp. 1749
Author(s):  
Fatemeh Amini Chermahini ◽  
Elham Raeisi ◽  
Mathias Hossain Aazami ◽  
Abbas Mirzaei ◽  
Esfandiar Heidarian ◽  
...  

Background: Bromelain enhances anticancer impacts to chemotherapeutic agents. The question as to whether bromelain does promote in-vitro cytotoxic and proapoptotic effects of cisplatin on human prostatic carcinoma PC3 cell line was investigated. Materials and Methods: PC3 (human prostatic carcinoma) cells were treated either single or in combination with bromelain and/or cisplatin. MTT, clonogenic assay, flow cytometry and real-time quantitative polymerase chain reaction were used to investigate cell viability, colony formation, proapoptotic potential and p53 gene expression, respectively. Results: Cisplatin (IC10) combined with bromelain (IC40) significantly affected PC3 cell viability, inhibited colony formation, as well increased p53 proapoptotic gene expression compared to cisplatin single treatment. Nevertheless, bromelain-cisplatin chemoherbal combination did not display any additive proapoptotic effect compared to single treatments. Conclusion: Bromelain-cisplatin chemoherbal combination demonstrated synergistic in-vitro anticancer effect on human prostatic carcinoma cell line, PC3, that drastically reduced required cisplatin dose. [GMJ.2020;9:e1749]


1986 ◽  
Vol 135 (4) ◽  
pp. 882-883
Author(s):  
M. Hasenson ◽  
B. Hartley-Asp ◽  
C. Kihlfors ◽  
A. Lundin ◽  
J.-Å. Gustafsson ◽  
...  

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