Sublingual More Effective Than Oral Misoprostol for Medical Abortion

Ob Gyn News ◽  
2008 ◽  
Vol 43 (1) ◽  
pp. 12
Author(s):  
NANCY WALSH
Keyword(s):  
Medical Abortion ◽  
Oral Misoprostol

scholarly journals Early pregnancy termination with a simplified mifepristone: Medical abortion outpatient regimen

1970 ◽  
Vol 7 (3) ◽  
pp. 209-212 ◽  
Author(s):  
N Chuni ◽  
TS Chandrashekhar
Keyword(s):  
Pregnancy Termination ◽  
Medical Abortion ◽  
Global Public Health ◽  
Public Health Importance ◽  
Safe Abortion ◽  
Nulliparous Women ◽  
Oral Misoprostol ◽  
Medical Termination ◽  
A Prospective Study ◽  
Home Administration

Background: An estimated 30 million abortions are performed worldwide every year. Many women do not have access to abortion and die of complications after illegal abortions. Medical abortion could provide greater access to safe abortion services; availability of the procedure is, therefore, of global public health importance. Aim: The aim was to study the efficacy of lowered dose of Mifepristone in medical abortion. Materials and methods: One hundred and twelve cases with a pregnancy of 63 days duration or less were enrolled in a prospective study using a lowered dose of 200mg Mifepristone followed, 48 hours later, by home administration of 400μg Misoprostol orally. At the second visit, on day 15, outcome and adverse effects were analysed. Women who failed to undergo a complete abortion were further managed by surgical evacuation of uterus. Results: The mean gestational age was 50.6 days. The rates of complete abortion were 92.8%, 83 % and 80 % in the ≤49 days group, 50 to 56 days and 57 to 63 days group respectively. Vaginal bleeding emerged as the biggest reason for medically indicated termination. Nulliparous women had a greater frequency of side effects, though values did not reach statistical signifi cance. Conclusion: This regimen of a lower dose of 200mg Mifepristone, followed by home administration of 400μg oral Misoprostol 48 hours later is safe and highly effective especially in pregnancies of up to 49 days duration. Key words: Mifepristone; Medical termination of pregnancy (MTP) DOI: 10.3126/kumj.v7i3.2725 Kathmandu University Medical Journal (2009) Vol.7, No.3 Issue 27, 209-212

scholarly journals A comparative study of sublingual versus oral misoprostol following oral mifepristone for second trimester termination of pregnancy

2019 ◽  
Vol 8 (2) ◽  
pp. 498
Author(s):  
Ruchi Gupta ◽  
Krishna Priya Banerjee ◽  
Reena Pant
Keyword(s):  
Success Rate ◽  
Medical Abortion ◽  
Oral Route ◽  
Termination Of Pregnancy ◽  
Second Trimester ◽  
Oral Misoprostol ◽  
Sublingual Misoprostol ◽  
Group A ◽  
The Mean ◽  
Group B

Background: The objective of this study is to assess the effectualness and safety of sublingual versus oral misoprostol following oral mifepristone for second trimester termination of pregnancy.Methods: This institution based contingent study was conducted on 220 women requesting for mid-trimester termination of pregnancy between 12-20 weeks with legal indication as per Govt. MTP act. After excluding the women as per exclusion criteria, they were randomly allocated into two groups (Group A Sublingual, Group B Oral), the women received 200 mg oral mifepristone followed by sublingual or oral misoprostol 400µg three hourly for a maximum of 5 doses 48 hours later. The course of misoprostol was reiterated if women failed to abort in 24 hours.Results: The mean induction-abortion interval of Group-A and Group -B was 4.02±1.39 hours and 6.44±1.79 hours respectively. The mean dose of misoprostol in Group–A and Group-B was 680±220.4µg and 1003.6±274.9µg. Hence mean Induction-abortion interval and dose were shortened in  Group-A as compare to Group-B (p <0.05). There was 100% success rate noticed via both routes. Evacuation was done in 4 (3.64%) women in Group-B as compare to only 1 (0.91%) in Group-A . The acceptability was significantly more in Group-B (100%) as compare Group-A (52.73%), probably because of unpleasant taste of sublingual misoprostol. All side effects (Nausea, pain, headache, and diarrhea) were common in both the Groups, only fever was significantly more common in sublingual group as compare to oral group (p<0.05).Conclusions: From present study authors conclude that, sublingual misoprostol when combined with mifepristone is effective for medical abortion in second trimester in terms of effectualness, endurability and success rate than oral route.

scholarly journals Mifepristone and Oral Misoprostol for Early Medical Abortion

1970 ◽  
Vol 7 (2) ◽  
pp. 127-130 ◽  
Author(s):  
V Shrivastava ◽  
A Shrivastava
Keyword(s):  
Pregnant Women ◽  
Success Rate ◽  
Research Council ◽  
Medical Abortion ◽  
Termination Of Pregnancy ◽  
Medical Termination Of Pregnancy ◽  
Oral Misoprostol ◽  
Medical Termination ◽  
Health Research Council ◽  
Good Success Rate

Background: Combined mifepristone and misoprostol is the best method of medical termination of pregnancy. The study is undertaken to find out the success rate, acceptability, efficacy and patient satisfaction of medical abortion in pregnant women with 49 days of gestation. Methods: The pregnant women with amenorrhea of 49 days or less seeking termination of pregnancy received were studied. The 200 mg of oral mifepristone and followed 48 hours later with 600 microgram of oral misoprostol were given. Results: The success rate with the regime was 47 (94%) and 49 (98%) were satisfied. Weakness 24 (48%), Nausea 10 (20%), diarrhea 12 (25%), needing analgesic 4 (8%) were the side effects of the combined regime. Conclusions: Medical termination of pregnancy with combination of mifepristone and oral misoprostol has a good success rate. The side effect of the regimen in our setup is less and well accepted. Majority of the patient are satisfied with medical termination of pregnancy. Key words: medical abortion; misoprostol; mifepristone DOI: 10.3126/jnhrc.v7i2.3021 Journal of Nepal Health Research Council Vol.7(2) Apr 2009 127-130

scholarly journals Medical Abortion in Early Pregnancy By oral Mifepristone And oral Misoprostol

2017 ◽  
Vol 16 (05) ◽  
pp. 19-21
Author(s):  
Dr. Chirom Pritam Kumar Singh ◽  
Dr. Ruma Sarkar
Keyword(s):  
Early Pregnancy ◽  
Medical Abortion ◽  
Oral Misoprostol

scholarly journals Feasibility and Acceptability of Medical Abortion at BPKIHS

1970 ◽  
Vol 8 (3) ◽  
pp. 142-146
Author(s):  
Ajay Agrawal ◽  
Mohan C Regmi ◽  
Dhruba Kumar Uprety ◽  
Hanoon Pokhrel ◽  
Pappu Rijal
Keyword(s):  
Pregnant Women ◽  
Medical Abortion ◽  
Termination Of Pregnancy ◽  
Prospective Data ◽  
Operational Requirement ◽  
Oral Misoprostol ◽  
Early Abortion ◽  
Home Administration ◽  
At Home

Objective: To test the feasibility and acceptability of a simplified mifepristone-misoprostol regimen for early abortion at BPKIHS.Methods: Pregnant women (n=100) with amenorrhea of 56 days or less seeking termination of pregnancy received 200mg of oral mifepristone followed 48hours later by 400 μg of oral misoprostol, administered either at home or at the clinic. Prospective data were collected to determine the women.s experience, abortion outcome, and the operational requirement for providing the method.Result: Most (91%) of the 88 women with known outcomes had successful medical abortions. Given the option, most (95.4%) women elected to administer the misoprostol at home. Conclusion: A simplified medical abortion protocol, including home administration of misoprostol, is highly safe, effective acceptable and feasible in our setting. Keywords: medical abortion; mifepristone; misoprostol DOI: 10.3126/hren.v8i3.4205Health Renaissance, September-December 2010; Vol 8 (No.3);142-146

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