Medical Abortion in Early Pregnancy By oral Mifepristone And oral Misoprostol

Objective: To compare the complete abortion rate, the induction-to-abortion time, and side effects between 600 mcg and 800 mcg misoprostol sublingually. Materials and Methods: Total, of 108 pregnant women with gestational age less than 12 weeks with early pregnancy loss from March 2020 to February 2021 at the Department of Obstetrics and Gynecology, Queen Savang Vadhana Memorial Hospital, were included. For group 1 (n=54), 600 mcg misoprostol was administrated sublingually. For group 2 (n=54), 800 mcg misoprostol was administrated sublingually. If the abortion did not occur, the repeated misoprostol in the same dose would be administrated sublingually every 6 hours for a maximum of three doses. Results: There was no significant difference in the complete abortion rate between the two groups (55.6% in the 600 mcg misoprostol group, 64.7% in the 800 mcg misoprostol group, p=0.339, and 95% CI 0.082 to 1.862). The induction-to-abortion time was 9.5 hours (IQR 6.75 to 48.00) in the 600 mcg misoprostol group and 10 hours (IQR 6.00 to 60.00) in the 800 mcg misoprostol group. The side effects of both groups were similar, included abdominal pain, diarrhea, nausea and vomiting, fever, heavy bleeding, and headache. Conclusion: The efficacy of the 600 mcg misoprostol was noninferior to 800 mcg misoprostol. The adverse effects were similar in both groups. Mean induction-to-abortion time was also similar in both groups. Keywords: Early pregnancy loss; Misoprostol; Medical abortion

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Medical abortion in early pregnancy: experience in China

Contraception ◽

10.1016/j.contraception.2006.03.004 ◽

2006 ◽

Vol 74 (1) ◽

pp. 61-65 ◽

Cited By ~ 17

Author(s):

Linan Cheng

Keyword(s):

Early Pregnancy ◽

Medical Abortion

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Medical Abortion in Early Pregnancy

Management of Unintended and Abnormal Pregnancy ◽

10.1002/9781444313031.ch9 ◽

2009 ◽

pp. 111-134 ◽

Cited By ~ 6

Author(s):

Mitchell D. Creinin ◽

Kristina Gemzell Danielsson

Keyword(s):

Early Pregnancy ◽

Medical Abortion

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Effect of mifepristone and lithospermum combination regimen on medical abortion in early pregnancy rats

Journal of Obstetrics and Gynaecology Research ◽

10.1111/jog.15007 ◽

2021 ◽

Author(s):

Qiong Yu ◽

Shihong Hu ◽

Shifu Hu

Keyword(s):

Early Pregnancy ◽

Medical Abortion ◽

Combination Regimen

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Early pregnancy termination with a simplified mifepristone: Medical abortion outpatient regimen

Kathmandu University Medical Journal ◽

10.3126/kumj.v7i3.2725 ◽

1970 ◽

Vol 7 (3) ◽

pp. 209-212 ◽

Cited By ~ 3

Author(s):

N Chuni ◽

TS Chandrashekhar

Keyword(s):

Pregnancy Termination ◽

Medical Abortion ◽

Global Public Health ◽

Public Health Importance ◽

Safe Abortion ◽

Nulliparous Women ◽

Oral Misoprostol ◽

Medical Termination ◽

A Prospective Study ◽

Home Administration

Background: An estimated 30 million abortions are performed worldwide every year. Many women do not have access to abortion and die of complications after illegal abortions. Medical abortion could provide greater access to safe abortion services; availability of the procedure is, therefore, of global public health importance. Aim: The aim was to study the efficacy of lowered dose of Mifepristone in medical abortion. Materials and methods: One hundred and twelve cases with a pregnancy of 63 days duration or less were enrolled in a prospective study using a lowered dose of 200mg Mifepristone followed, 48 hours later, by home administration of 400μg Misoprostol orally. At the second visit, on day 15, outcome and adverse effects were analysed. Women who failed to undergo a complete abortion were further managed by surgical evacuation of uterus. Results: The mean gestational age was 50.6 days. The rates of complete abortion were 92.8%, 83 % and 80 % in the ≤49 days group, 50 to 56 days and 57 to 63 days group respectively. Vaginal bleeding emerged as the biggest reason for medically indicated termination. Nulliparous women had a greater frequency of side effects, though values did not reach statistical signifi cance. Conclusion: This regimen of a lower dose of 200mg Mifepristone, followed by home administration of 400μg oral Misoprostol 48 hours later is safe and highly effective especially in pregnancies of up to 49 days duration. Key words: Mifepristone; Medical termination of pregnancy (MTP) DOI: 10.3126/kumj.v7i3.2725 Kathmandu University Medical Journal (2009) Vol.7, No.3 Issue 27, 209-212

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A comparative study of sublingual versus oral misoprostol following oral mifepristone for second trimester termination of pregnancy

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20190274 ◽

2019 ◽

Vol 8 (2) ◽

pp. 498

Author(s):

Ruchi Gupta ◽

Krishna Priya Banerjee ◽

Reena Pant

Keyword(s):

Success Rate ◽

Medical Abortion ◽

Oral Route ◽

Termination Of Pregnancy ◽

Second Trimester ◽

Oral Misoprostol ◽

Sublingual Misoprostol ◽

Group A ◽

The Mean ◽

Group B

Background: The objective of this study is to assess the effectualness and safety of sublingual versus oral misoprostol following oral mifepristone for second trimester termination of pregnancy.Methods: This institution based contingent study was conducted on 220 women requesting for mid-trimester termination of pregnancy between 12-20 weeks with legal indication as per Govt. MTP act. After excluding the women as per exclusion criteria, they were randomly allocated into two groups (Group A Sublingual, Group B Oral), the women received 200 mg oral mifepristone followed by sublingual or oral misoprostol 400µg three hourly for a maximum of 5 doses 48 hours later. The course of misoprostol was reiterated if women failed to abort in 24 hours.Results: The mean induction-abortion interval of Group-A and Group -B was 4.02±1.39 hours and 6.44±1.79 hours respectively. The mean dose of misoprostol in Group–A and Group-B was 680±220.4µg and 1003.6±274.9µg. Hence mean Induction-abortion interval and dose were shortened in Group-A as compare to Group-B (p <0.05). There was 100% success rate noticed via both routes. Evacuation was done in 4 (3.64%) women in Group-B as compare to only 1 (0.91%) in Group-A . The acceptability was significantly more in Group-B (100%) as compare Group-A (52.73%), probably because of unpleasant taste of sublingual misoprostol. All side effects (Nausea, pain, headache, and diarrhea) were common in both the Groups, only fever was significantly more common in sublingual group as compare to oral group (p<0.05).Conclusions: From present study authors conclude that, sublingual misoprostol when combined with mifepristone is effective for medical abortion in second trimester in terms of effectualness, endurability and success rate than oral route.

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