ß2-partial agonist activity of indenolol, a new non selective ß-adrenergic blocker. In vitro study

1988 ◽  
Vol 20 ◽  
pp. 143
Author(s):  
D. Faini ◽  
M. Barchielli ◽  
A. Pinzetta ◽  
C. Turba
Keyword(s):  
Partial Agonist ◽  
In Vitro Study ◽  
Vitro Study ◽  
Agonist Activity ◽  
Partial Agonist Activity ◽  
Adrenergic Blocker

scholarly journals Partial agonist activity of R3(BΔ23–27)R/I5 at RXFP3 – Investigation of in vivo and in vitro pharmacology

2015 ◽  
Vol 747 ◽  
pp. 123-131 ◽  
Author(s):  
Lisbeth Kristensson ◽  
Gaëll Mayer ◽  
Karolina Ploj ◽  
Martina Wetterlund ◽  
Susanne Arlbrandt ◽  
...  
Keyword(s):  
Partial Agonist ◽  
Agonist Activity ◽  
Partial Agonist Activity ◽  
In Vitro Pharmacology

scholarly journals Transactivation Function-1-Mediated Partial Agonist Activity of Selective Estrogen Receptor Modulator Requires Homo-Dimerization of the Estrogen Receptor α Ligand Binding Domain

2019 ◽  
Vol 20 (15) ◽  
pp. 3718 ◽  
Author(s):  
Yukitomo Arao ◽  
Kenneth S. Korach
Keyword(s):  
Estrogen Receptor ◽  
Ligand Binding ◽  
Partial Agonist ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Agonist Activity ◽  
Partial Agonist Activity

The isolation of estrogen receptor alpha (ERα) cDNA was successful around 30 years ago. The characteristics of ERα protein have been examined from various aspects, primarily through in vitro cell culture studies, but more recently using in vivo experimental models. There remains, however, some uncharacterized ERα functionalities. In particular, the mechanism of partial agonist activity of selective estrogen receptor modulators (SERMs) that involves control of the N-terminal transcription function of ERα, termed AF-1, is still an unsolved ERα functionality. We review the possible mechanism of SERM-dependent regulation of ERα AF-1-mediated transcriptional activity, which includes the role of helix 12 of ERα ligand binding domain (LBD) for SERM-dependent AF-1 regulation. In addition, we describe a specific portion of the LBD that associates with blocking AF-1 activity with an additional role of the F-domain in mediating SERM activity.

In vitro study of the interaction between human gut microbiota and herbal extracts using willow bark extract as an example

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
EM Pferschy-Wenzig ◽  
K Koskinen ◽  
C Moissl-Eichinger ◽  
R Bauer
Keyword(s):  
Gut Microbiota ◽  
In Vitro Study ◽  
Vitro Study ◽  
Bark Extract ◽  
Herbal Extracts ◽  
Human Gut ◽  
Human Gut Microbiota ◽  
Willow Bark

Evaluation of the Release Behavior of the Dexamethasone Embedded in Polycarbonate Polyurethane Membranes: An In Vitro Study

2003 ◽  
Vol 48 (1) ◽  
pp. 7 ◽  
Author(s):  
Dong Hyun Kim ◽  
Sung Gwon Kang ◽  
Sang Soo Park ◽  
Don Haeng Lee ◽  
Gyu Baek Lee ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Release Behavior ◽  
Polyurethane Membranes
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