Dose-response analysis of short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in three differentially susceptible rat lines

2003 ◽  
Vol 187 (2) ◽  
pp. 128-136 ◽  
Author(s):  
Ulla Simanainen ◽  
Jouni T. Tuomisto ◽  
Jouko Tuomisto ◽  
Matti Viluksela
Keyword(s):  
Dose Response ◽  
Response Analysis ◽  
Short Term ◽  
Tetrachlorodibenzo P Dioxin ◽  
Short Term Effects

scholarly journals Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants

2017 ◽  
Vol 109 ◽  
pp. 690-702 ◽  
Author(s):  
Isabelle R. Miousse ◽  
Lynea A. Murphy ◽  
Haixia Lin ◽  
Melissa R. Schisler ◽  
Jinchun Sun ◽  
...  
Keyword(s):  
Dose Response ◽  
Response Analysis ◽  
Short Term ◽  
Short Term Exposure

Use of the perifusion technique on rat thyroid fragments in the study of thyroid hormone secretion: short-term effects of thyrotrophin, theophylline and glucagon

1984 ◽  
Vol 102 (1) ◽  
pp. 43-NP ◽  
Author(s):  
J. R. Attali ◽  
D. Darnis ◽  
P. Valensi ◽  
C. Weisselberg ◽  
J. Sebaoun
Keyword(s):  
Thyroid Hormone ◽  
Dose Response ◽  
Linear Correlation ◽  
Hormone Secretion ◽  
Kinetic Studies ◽  
Dynamic Effects ◽  
Short Term ◽  
Pharmacological Agents ◽  
Rat Thyroid ◽  
Short Term Effects

ABSTRACT Perifusion of rat thyroid fragments was performed to study short-term effects of TSH, theophylline and glucagon on thyroid hormone secretion. This technique proved to be relatively convenient and sensitive, and gave reproducible results for at least 3 h, permitting precise kinetic studies of response to hormonal and pharmacological agents without any interference. There was a significant (P < 0·001) linear correlation between the log TSH concentrations over the range 20–150 mu./ml and thyroid response. A second stimulation, using the same concentration of TSH, did not differ from the first stimulation if they were separated by an active 'washing' period of only 15 min. Theophylline also had a stimulating effect and like TSH induced an early release of the hormone fraction with a peak between 2 and 4 min, but it did not potentiate the TSH effect. Perifusion of rat thyroid fragments was found to be a useful tool for analysing dynamic effects of various substances. These effects were significant for periods of time as short as 20 min. Each thyroid preparation could be used a second time for another pharmacological or hormonal test. Our preliminary results also suggested that there was a direct glucagon effect on thyroid hormone secretion with a dose–response correlation. J. Endocr. (1984) 102, 43–48

A Dose-Response Analysis of Nicotine Sensitization in Adolescent Rats D2-Primed as Neonates

2010 ◽  
Author(s):  
Elizabeth A. Hanchak ◽  
Meredith L. Smith ◽  
Jessie J. Smith ◽  
Marla K. Perna ◽  
Russell W. Brown
Keyword(s):  
Dose Response ◽  
Response Analysis ◽  
Adolescent Rats
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