Dendritic cells, generated in vitro, are immunocompetent and very useful in the induction of specific cytotoxic T lymphocyte activity

2001 ◽  
Vol 33 (7-8) ◽  
pp. 3814-3815 ◽  
Author(s):  
T Hasel ◽  
R Yoshimura ◽  
S Wada ◽  
J Chargui
Keyword(s):  
Dendritic Cells ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Activity

scholarly journals Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro.

1992 ◽  
Vol 175 (2) ◽  
pp. 609-612 ◽  
Author(s):  
S Nair ◽  
F Zhou ◽  
R Reddy ◽  
L Huang ◽  
B T Rouse
Keyword(s):  
Dendritic Cells ◽  
T Lymphocyte ◽  
Antigen Processing ◽  
Vaccine Development ◽  
Cytotoxic T Lymphocyte ◽  
Present Report ◽  
Soluble Proteins ◽  
Ph Sensitive ◽  
Ctl Response

Effective immunity to many infectious agents, particularly viruses, requires a CD8+ cytotoxic T lymphocyte (CTL) response. Understanding how to achieve CTL induction with soluble proteins is important for vaccine development since such antigens are usually not processed appropriately to induce CTL. In the present report, we have demonstrated that a potent primary CTL response against a soluble protein can be achieved by delivering antigen in pH-sensitive liposomes to dendritic cells (DC) either in vivo or in vitro. Since the pH-sensitive liposome delivery system is efficient and easy to use, the approach promises to be valuable both in the study of basic mechanisms in antigen processing, and as a practical means of immunization.

scholarly journals Use of a High-Affinity Peptide That Aborts MHC-Restricted Cytotoxic T Lymphocyte Activity against Multiple Viruses in Vitro and Virus-Induced Immunopathologic Disease in Vivo

Virology ◽  
1999 ◽  
Vol 256 (2) ◽  
pp. 246-257 ◽  
Author(s):  
Michael B.A. Oldstone ◽  
Matthias von Herrath ◽  
Hanna Lewicki ◽  
Denis Hudrisier ◽  
J.Lindsay Whitton ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
High Affinity ◽  
Lymphocyte Activity ◽  
Affinity Peptide

Induction of Tc1 response and enhanced cytotoxic T lymphocyte activity in mice by dendritic cells transduced with adenovirus expressing HBsAg

2006 ◽  
Vol 119 (3) ◽  
pp. 280-290 ◽  
Author(s):  
Yin Huang ◽  
Zhi Chen ◽  
Hongyu Jia ◽  
Wei Wu ◽  
Shigen Zhong ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Activity
Sign in / Sign up

Export Citation Format

Share Document