Marginal donors in liver transplantation: the role of donor age

1999 ◽  
Vol 31 (1-2) ◽  
pp. 397-400 ◽  
Author(s):  
L De Carlis ◽  
G Colella ◽  
C.V Sansalone ◽  
P Aseni ◽  
G.F Rondinara ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Donor Age ◽  
Marginal Donors

scholarly journals Optimization of long-term graft survival after liver transplantation: the role of donor age

2011 ◽  
Vol 11 (Suppl 1) ◽  
pp. A25 ◽  
Author(s):  
Q Lai ◽  
F Melandro ◽  
G Spoletini ◽  
GB Levi Sandri ◽  
N Guglielmo ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Donor Age

scholarly journals The role of marginal donors in liver transplantation. The Hungarian experience

2009 ◽  
Vol 150 (49) ◽  
pp. 2228-2236 ◽  
Author(s):  
Balázs Nemes ◽  
Fanni Gelley ◽  
Gergely Zádori ◽  
Dénes Görög ◽  
Imre Fehérvári ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hungarian Experience ◽  
Donor Criteria ◽  
Marginal Donors ◽  
Extended Donor Criteria

A májátültetések számát korlátozza a beültetésre alkalmas donorszervek mennyisége. A szervhiány megoldására az egyik lehetőség az úgynevezett marginális donorok (extended donor criteria) elfogadása a májátültetési programban. Célkitűzés: A magyar májátültetési program szervdonációs jellemzőinek vizsgálata, különös tekintettel a marginális donorokra. Módszer: Donor- és recipiensadatok retrospektív feldolgozása 2003. január és 2008. december között. A marginálisdonor-kritériumrendszert nemzetközi ajánlások alapján állítottuk fel. Eredmények: A vizsgált periódus alatt összesen 1078 donort jelentettek a klinikán. Nyolcszázharmincöt esetben (77,4%) alkalmatlannak ítélték a donormájat a transzplantációra, 243 esetben (22,6%) volt beültetésre alkalmas a donormáj. A beültetett májgraftok közül 40 (16%) származott marginális, 203 (84%) nem marginális donorból. Marginális májgraftok beültetése esetén nem volt különbség a beteg- és grafttúlélésben, a posztoperatív graftfunkciót jelző paraméterekben és az általános szövődmények gyakoriságában. A korai hepatitis C-rekurrencia gyakoribb volt marginális graft beültetése esetén. Következtetések: A májátültetésre váró betegek száma hazánkban is folyamatosan növekszik. Marginális májgraftok alkalmazása esetén a betegek morbiditása és mortalitása nem különbözik számottevően a standard donorokból származó májgraftok beültetése után tapasztalt eredményektől. Hepatitis C-vírus esetén nem javasolt marginális májgraft beültetése. A donorok felső életkori határának kiterjesztése megfontolandó.

scholarly journals Network pharmacology-based analysis of the role of tacrolimus in liver transplantation

2021 ◽  
Author(s):  
Lijian Chen ◽  
Yuming Peng ◽  
Chunyi Ji ◽  
Miaoxian Yuan ◽  
Qiang Yin
Keyword(s):  
Liver Transplantation ◽  
Network Pharmacology

The role of autonomic dysfunction in predicting 1-year mortality after liver transplantation

2017 ◽  
Vol 37 (8) ◽  
pp. 1239-1248 ◽  
Author(s):  
Kuang-Cheng Chan ◽  
Jia-Rong Yeh ◽  
Wei-Zen Sun
Keyword(s):  
Liver Transplantation ◽  
Autonomic Dysfunction

The Need for Consensus About Liver Transplantation For Patients With Neuropsychiatric Wilson’s Disease

2021 ◽  
pp. 152692482110028
Author(s):  
Alberto Ferrarese ◽  
Patrizia Burra
Keyword(s):  
Liver Transplantation ◽  
Patient Outcomes ◽  
Wilson’S Disease ◽  
Therapeutic Option ◽  
Copper Metabolism ◽  
Wilson's Disease ◽  
Published Data ◽  
Neurological Improvement ◽  
Effective Therapeutic Option

Liver transplantation is considered an effective therapeutic option for Wilson’s disease (WD) patients with hepatic phenotype, since it removes the inherited defects of copper metabolism, and is associated with excellent graft and patient outcomes. The role of liver transplantation in WD patients with mixed hepatic and neuropsychiatric phenotype has remained controversial over time, mainly because of high post-operative complications, reduced survival and a variable, unpredictable rate of neurological improvement. This article critically discusses the recently published data in this field, focussing in more detail on isolated neuropsychiatric phenotype as a potential indication for liver transplantation in WD patients.

scholarly journals Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical Alternatives

2021 ◽  
Vol 11 (6) ◽  
pp. 499
Author(s):  
Michele Finotti ◽  
Maurizio Romano ◽  
Pasquale Auricchio ◽  
Michele Scopelliti ◽  
Marco Brizzolari ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Fatty Liver Disease ◽  
Hepatic Disease ◽  
Lifestyle Modifications ◽  
Alcoholic Fatty Liver ◽  
Target Therapies ◽  
Chronic Hepatic Disease ◽  
The Impact ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease represents an increasing cause of chronic hepatic disease in recent years. This condition usually arises in patients with multiple comorbidities, the so-called metabolic syndrome. The therapeutic options are multiple, ranging from lifestyle modifications, pharmacological options, to liver transplantation in selected cases. The choice of the most beneficial one and their interactions can be challenging. It is mandatory to stratify the patients according to the severity of their disease to tailor the available treatments. In our contribution, we review the most recent pharmacological target therapies, the role of bariatric surgery, and the impact of liver transplantation on the NAFLD outcome.

scholarly journals The Role of Liver Transplantation in the Management of Paediatric Liver Tumours

2007 ◽  
Vol 89 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Mark D Stringer
Keyword(s):  
Liver Transplantation ◽  
Hepatocellular Cancer ◽  
Good Prognosis ◽  
Liver Tumours ◽  
Primary Hepatic Malignancies ◽  
Life Saving ◽  
Time Of Presentation ◽  
Benign Liver ◽  
Hepatic Malignancies

In recent years, considerable progress has been made in the treatment of children with hepatoblastoma largely due to effective pre-operative chemotherapy. Total hepatectomy and liver transplantation has emerged as an effective treatment for the small proportion of children with unresectable hepatoblastoma limited to the liver. A 5-year survival of 70% can be achieved in such cases. In contrast, the results of liver transplantation in children with hepatocellular cancer remain poor because these tumours are usually advanced with evidence of major vascular invasion and/or extrahepatic spread at the time of presentation. An exception is those children in whom the hepatocellular carcinoma is detected during surveillance of chronic liver disease – they typically have smaller tumours and frequently have a good prognosis after liver transplantation. The role of liver transplantation in children with other primary hepatic malignancies remains uncertain because experience is very limited. Liver transplantation is rarely needed in the management of children with benign liver tumours but, if other treatments have failed, it can be a life-saving intervention.

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