Levothyroxine Treatment in Euthyroid Pregnant Women with Autoimmune Thyroid Disease: Effects on Obstetrical Complications

2007 ◽  
Vol 2007 ◽  
pp. 217-220
Author(s):  
E.L. Mazzaferri
Keyword(s):  
Pregnant Women ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid ◽  
Obstetrical Complications ◽  
Levothyroxine Treatment

scholarly journals Levothyroxine Treatment in Euthyroid Pregnant Women with Autoimmune Thyroid Disease: Effects on Obstetrical Complications

2006 ◽  
Vol 91 (7) ◽  
pp. 2587-2591 ◽  
Author(s):  
Roberto Negro ◽  
Gianni Formoso ◽  
Tiziana Mangieri ◽  
Antonio Pezzarossa ◽  
Davide Dazzi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid ◽  
Obstetrical Complications ◽  
Levothyroxine Treatment

Severe selenium deficits in pregnant women irrespective of autoimmune thyroid disease in an area with marginal selenium intake

2017 ◽  
Vol 44 ◽  
pp. 186-191 ◽  
Author(s):  
Urszula Ambroziak ◽  
Sandra Hybsier ◽  
Urszula Shahnazaryan ◽  
Małgorzata Krasnodębska-Kiljańska ◽  
Eddy Rijntjes ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid ◽  
Selenium Intake

scholarly journals Effects of levothyroxine treatment on pregnancy outcomes in pregnant women with autoimmune thyroid disease

2017 ◽  
Vol 176 (2) ◽  
pp. 253-265 ◽  
Author(s):  
Sima Nazarpour ◽  
Fahimeh Ramezani Tehrani ◽  
Masoumeh Simbar ◽  
Maryam Tohidi ◽  
Hamid Alavi Majd ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcome ◽  
Preterm Delivery ◽  
Pregnancy Outcomes ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Autoimmune Thyroid ◽  
Adverse Pregnancy ◽  
Group B

Background Despite some studies indicating that thyroid antibody positivity during pregnancy has been associated with adverse pregnancy outcomes, evidence regarding the effects of levothyroxine (LT4) treatment of euthyroid/subclinical hypothyroid pregnant women with autoimmune thyroid disease on pregnancy outcome is limited. We aimed to assess whether pregnant women with autoimmune thyroid disease, but without overt thyroid dysfunction are affected by higher rates of adverse pregnancy outcomes. In addition, we aimed to explore whether LT4 treatment improves the pregnancy outcome of affected women. Methods A prospective study was carried out on pregnant women from the first trimester to delivery. The study was conducted among pregnant women receiving prenatal care in centers under coverage of Shahid Beheshti University of Medical Sciences. Of a total of 1746 pregnant women, screened for thyroid dysfunction, 1028 euthyroid TPOAb-negative (TPOAb−) and 131 thyroid peroxidase antibody-positive (TPOAb+) women without overt thyroid dysfunction entered the second phase of the study. TPOAb+ women were randomly divided into two groups: group A (n = 65), treated with LT4 and group B (n = 66), received no treatment. The 1028 TPOAb− women (group C) served as a normal population control group. Primary outcomes were preterm delivery and miscarriage and secondary outcomes included placenta abruption, still birth, neonatal admission and neonatal TSH levels. Results Groups A and C displayed a lower rate of preterm deliveries compared with group B (RR = 0.30, 95% CI: 0.1–0.85, P = 0.0229) and (RR = 0.23, 95% CI: 0.14–0.40, P < 0.001) respectively. There was no statistically significant difference in the rates of preterm labor between groups A and C (RR = 0.79, 95% CI: 0.30–2.09, P = 0.64). The number needed to treat (NNT) for preterm birth was 5.9 (95% CI: 3.33–25.16) Conclusions Treatment with LT4 decreases the risk of preterm delivery in women who are positive for TPOAb.

scholarly journals Individualized Follow-up of Pregnant Women with Asymptomatic Autoimmune Thyroid Disease

2016 ◽  
Vol 17 (1) ◽  
pp. 88 ◽  
Author(s):  
Dana Stoian ◽  
Stelian Pantea ◽  
Madalin Margan ◽  
Bogdan Timar ◽  
Florin Borcan ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid

Thyroid Disease in Pregnancy

2008 ◽  
Vol 04 (01) ◽  
pp. 100
Author(s):  
N Pearce Elizabeth ◽  
M Leung Angela
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Thyroid Function Test ◽  
Autoimmune Thyroid ◽  
Thyroid Screening ◽  
Function Test ◽  
In Pregnancy

The spectrum of thyroid disease in pregnancy has implications for both the mother and the developing fetus. Here we review the interpretation of thyroid function test values, thyrotoxicosis, hypothyroidism, iodine requirements, autoimmune thyroid disease, and thyroid screening recommendations as they pertain to pregnant women. It should be noted that the management of thyroid dysfunction in pregnancy should be closely co-ordinated with obstetricians and other providers.

Optimization of the follow-up of pregnant women with autoimmune thyroid disease

2019 ◽  
Vol 66 (5) ◽  
pp. 305-311
Author(s):  
M. Dolores Ollero ◽  
Javier Pineda ◽  
Juan Pablo Martínez de Esteban ◽  
Marta Toni ◽  
Mercedes Espada ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid

scholarly journals Cost-Effectiveness of Universal and Risk-Based Screening for Autoimmune Thyroid Disease in Pregnant Women

2012 ◽  
Vol 97 (5) ◽  
pp. 1536-1546 ◽  
Author(s):  
Chrysoula Dosiou ◽  
James Barnes ◽  
Alan Schwartz ◽  
Roberto Negro ◽  
Lawrence Crapo ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Pregnant Women ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid

scholarly journals Screening pregnant women for autoimmune thyroid disease: a cost-effectiveness analysis.

2008 ◽  
Vol 158 (6) ◽  
pp. 841-851 ◽  
Author(s):  
Chrysoula Dosiou ◽  
Gillian D Sanders ◽  
Sally S Araki ◽  
Lawrence M Crapo
Keyword(s):  
Cost Effectiveness ◽  
Pregnant Women ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Cost Effective ◽  
First Trimester ◽  
Screening Tests ◽  
Autoimmune Thyroid ◽  
Effectiveness Analysis ◽  
The Cost

ObjectiveUntreated maternal hypothyroidism during pregnancy can have adverse consequences on maternal health and child intelligence quotient (IQ). Our objective was to examine the cost-effectiveness of screening pregnant women for autoimmune thyroid disease.DesignWe developed a state-transition Markov model and performed a cost-effectiveness analysis of screening pregnant US women, aged 15–45 years, with no known history of thyroid disease, in the first trimester.MethodsThree strategies were compared: 1) no screening, 2) one-time screening using anti-thyroid peroxidase (anti-TPO) antibodies, and 3) one-time screening using TSH. Screening tests were added to the laboratory tests of the first prenatal visit. Abnormal screening tests were followed by further testing and subsequent thyroxine treatment of hypothyroid women.ResultsScreening pregnant women in the first trimester using TSH was cost-saving compared with no screening. Screening using anti-TPO antibodies was cost-effective compared with TSH screening with an incremental cost-effectiveness ratio of $15 182 per quality-adjusted life year. Screening using TSH remained cost-saving across a wide range of ages at screening, costs of treatment, and probabilities of adverse outcomes. The cost-effectiveness of anti-TPO screening compared with TSH screening was mostly influenced by the probability of diagnosing hypothyroidism in unscreened subjects or subjects with a normal screening test. Screening remained highly cost-effective in scenarios where we assumed no improvement of child IQ outcomes by levothyroxine treatment.ConclusionScreening all pregnant women for autoimmune thyroid disease in the first trimester is cost-effective compared with not screening.

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