Tacrolimus ointment monotherapy is safe and effective for the long-term treatment (more than 3 years) of atopic dermatitis in pediatric patients

2003 ◽  
Vol 111 (2) ◽  
pp. S130 ◽  
Author(s):  
J.M. Hanifin ◽  
D.Y. Leung ◽  
A. Paller ◽  
J. Rico
Keyword(s):  
Atopic Dermatitis ◽  
Pediatric Patients ◽  
Term Treatment ◽  
Tacrolimus Ointment ◽  
Long Term Treatment

scholarly journals Pediatric Atopic Dermatitis: Update on the Treatment Options

2020 ◽  
Vol 25 (4) ◽  
pp. 60-62
Author(s):  
Corina Adelina Zah ◽  
Andreea Emiliana Toporău ◽  
Paul Grama
Keyword(s):  
Atopic Dermatitis ◽  
Chronic Treatment ◽  
Pediatric Patients ◽  
Treatment Options ◽  
Chronic Inflammatory Disease ◽  
Term Treatment ◽  
Phosphodiesterase 4 ◽  
Systemic Corticosteroids ◽  
Long Term Treatment

Abstract Atopic dermatitis (AD) is a chronic inflammatory disease characterized by skin dryness, pruritus and eczematous lesions with various periods of relapse. Symptomatology can appear in childhood and can persist in adulthood. Chronic treatment is required with corticosteroids being the standard options. The side effects of this type of long-term treatment represent a major concern for the pediatric patients. This review aims to give an update of the options used for treatment, apart from the systemic corticosteroids. Mild-to-moderate AD had a good response to creams containing fig and oatmeal extracts and inhibitors of phosphodiesterase-4 (crisaborole). In cases of severe AD, future treatment options could include monoclonal antibodies such as omalizumab and dupilumab

scholarly journals Long-term Treatment of Severe Recalcitrant Atopic Dermatitis with Omalizumab, an Anti-immuno-globulin E

2013 ◽  
Vol 93 (2) ◽  
pp. 206-208 ◽  
Author(s):  
S Quist ◽  
A Ambach ◽  
D Göppner ◽  
J Quist ◽  
I Franke ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Term Treatment ◽  
Long Term Treatment

scholarly journals Electrospun Orodispersible Films of Isoniazid for Pediatric Tuberculosis Treatment

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 470 ◽  
Author(s):  
Konstantina Chachlioutaki ◽  
Emmanouil K. Tzimtzimis ◽  
Dimitrios Tzetzis ◽  
Ming-Wei Chang ◽  
Zeeshan Ahmad ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Drug Loading ◽  
Term Treatment ◽  
Adherence To Treatment ◽  
Disintegration Time ◽  
Orodispersible Films ◽  
Long Term Treatment ◽  
Pediatric Patient Population ◽  
Pediatric Tuberculosis

Child-appropriate dosage forms are critical in promoting adherence and effective pharmacotherapy in pediatric patients, especially those undergoing long-term treatment in low-resource settings. The present study aimed to develop orodispersible films (ODFs) for isoniazid administration to children exposed to tuberculosis. The ODFs were produced from the aqueous solutions of natural and semi-synthetic polymer blends using electrospinning. The spinning solutions and the resulting fibers were physicochemically characterized, and the disintegration time and isoniazid release from the ODFs were assessed in simulated salivary fluid. The ODFs comprised of nanofibers with adequate thermal stability and possible drug amorphization. Film disintegration occurred instantly upon contact with simulated salivary fluid within less than 15 s, and isoniazid release from the ODFs in the same medium followed after the disintegration profiles, achieving rapid and total drug release within less than 60 s. The ease of administration and favorable drug loading and release properties of the ODFs may provide a dosage form able to facilitate proper adherence to treatment within the pediatric patient population.

Sign in / Sign up

Export Citation Format

Share Document