Single‐Particle Electron Cryomicroscopy of the Ion Channels in the Excitation–Contraction Coupling Junction

2007 ◽  
pp. 407-435 ◽  
Author(s):  
Irina I. Serysheva ◽  
Wah Chiu ◽  
Steven J. Ludtke
Keyword(s):  
Ion Channels ◽  
Single Particle ◽  
Electron Cryomicroscopy ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling

Calmodulin and Excitation-Contraction Coupling

Physiology ◽  
2000 ◽  
Vol 15 (6) ◽  
pp. 281-284 ◽  
Author(s):  
Susan L. Hamilton ◽  
Irina Serysheva ◽  
Gale M. Strasburg
Keyword(s):  
Skeletal Muscle ◽  
Ion Channels ◽  
Sarcoplasmic Reticulum ◽  
Release Channel ◽  
Excitation Contraction Coupling ◽  
Transverse Tubule ◽  
Contraction Coupling ◽  
Voltage Dependent ◽  
Important Regulator ◽  
Precise Role

Excitation-contraction coupling in cardiac and skeletal muscle involves the transverse-tubule voltage-dependent Ca2+ channel and the sarcoplasmic reticulum Ca2+ release channel. Both of these ion channels bind and are modulated by calmodulin in both its Ca2+-bound and Ca2+-free forms. Calmodulin is, therefore, potentially an important regulator of excitation-contraction coupling. Its precise role, however, has not yet been defined.

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