The Effect of Age on Susceptibility to Hypoxic-Ischemic Brain Damage

1997 ◽  
Vol 21 (2) ◽  
pp. 167-174 ◽  
Author(s):  
JEROME Y YAGER ◽  
JIM A THORNHILL
Keyword(s):  
Brain Damage ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Effect Of Age

Enriched environment and the effect of age on ischemic brain damage

2007 ◽  
Vol 1170 ◽  
pp. 31-38 ◽  
Author(s):  
Deborah M. Saucier ◽  
Jerome Y. Yager ◽  
Edward A. Armstrong ◽  
Avril Keller ◽  
Sandy Shultz
Keyword(s):  
Brain Damage ◽  
Enriched Environment ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Effect Of Age

Protective effect of intracerebral transplantation of human mesenchymal stem cells on hypoxic-ischemic brain damage in rats

2009 ◽  
Vol 28 (9) ◽  
pp. 1009-1014
Author(s):  
Jian-ling FAN ◽  
Xiao-yu LAI ◽  
Li HUANG ◽  
Yan WANG ◽  
Jun-li CAO ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Protective Effect ◽  
Brain Damage ◽  
Human Mesenchymal Stem Cells ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Intracerebral Transplantation

scholarly journals Targeting platelet glycoprotein VI attenuates progressive ischemic brain damage before recanalization during middle cerebral artery occlusion in mice

2021 ◽  
pp. 113804
Author(s):  
Michael Bieber ◽  
Michael K. Schuhmann ◽  
Alexander M. Kollikowski ◽  
David Stegner ◽  
Bernhard Nieswandt ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Brain Damage ◽  
Cerebral Artery ◽  
Artery Occlusion ◽  
Platelet Glycoprotein ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Glycoprotein Vi ◽  
Cerebral Artery Occlusion

Blockade of central histaminergic H2 receptors facilitates catecholaminergic metabolism and aggravates ischemic brain damage in the rat telencephalon

2003 ◽  
Vol 974 (1-2) ◽  
pp. 117-126 ◽  
Author(s):  
Ryu Otsuka ◽  
Naoto Adachi ◽  
Gen Hamami ◽  
Keyue Liu ◽  
Toshihiro Yorozuya ◽  
...  
Keyword(s):  
Brain Damage ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
H2 Receptors

Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization via inhibiting the TLR4/NF-κB and STAT1 pathway

2021 ◽  
pp. 147626
Author(s):  
Yuanyuan Ran ◽  
Shuyan Qie ◽  
Fuhai Gao ◽  
Zitong Ding ◽  
Shuiqing Yang ◽  
...  
Keyword(s):  
Brain Damage ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Microglia Polarization

Ischemic neuronal damage after acute subdural hematoma in the rat: effects of pretreatment with a glutamate antagonist

1991 ◽  
Vol 74 (6) ◽  
pp. 944-950 ◽  
Author(s):  
Min-Hsiung Chen ◽  
Ross Bullock ◽  
David I. Graham ◽  
Jimmy D. Miller ◽  
James McCulloch
Keyword(s):  
Brain Damage ◽  
Subdural Hematoma ◽  
Neuronal Damage ◽  
Nmda Receptor Antagonist ◽  
Acute Subdural Hematoma ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Content Type ◽  
Irreversible Brain Damage ◽  
Slow Injection

✓ The ability of a competitive N-methyl-D-aspartate (NMDA) receptor antagonist (D-CPP-ene) to reduce irreversible brain damage has been examined in a rodent model of acute subdural hematoma. Acute subdural hematoma was produced by the slow injection of 400 µl homologous blood into the subdural space overlying the parietal cortex in halothane-anesthetized rats. Brain damage was assessed histologically in sections at multiple coronal planes in animals sacrificed 4 hours after induction of the subdural hematoma. Pretreatment with D-CPP-ene (15 mg/kg) significantly reduced the volume of ischemic brain damage produced by the subdural hematoma from 62 ± 8 cu mm (mean ± standard error of the mean) in vehicle-treated control rats to 29 ± 7 cu mm in drug-treated animals. These data demonstrate the anti-ischemic efficacy of NMDA antagonists in an animal model of intracranial hemorrhage in which intracranial pressure is elevated, and suggest that excitotoxic mechanisms (which are susceptible to antagonism by D-CPP-ene) may play a role in the ischemic brain damage which is observed in patients who die after acute subdural hematoma.

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