The influence of intact and toxically injured liver cells on lymphocyte proliferation and differentiation after cyclooxygenase and lipoxygenase inhibition

This work is devoted to development of mathematical model, describing processes of Th and B lymphocyte proliferation and differentiation, as well as IFN-γ, IL-2, IL-4 and IL-21 cytokine secretion. New approaches are suggested, allowing more accurate modelling. Special attention paid to Th17 lymphocyte impact to effect of plasma cells and IgM and IgG antibody level increasing.

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Damage of Splenic T Lymphocyte Proliferation and Differentiation and Its Normalization by Electroacupuncture in Morphine-Dependent Mice Mode

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2011/424092 ◽

2011 ◽

Vol 2011 ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

Hong-Yu Li ◽

Rong Zhang ◽

Cai-Lian Cui ◽

Ji-Sheng Han ◽

Liu-Zhen Wu

Keyword(s):

Body Weight ◽

T Lymphocyte ◽

Lymphocyte Proliferation ◽

Baseline Level ◽

Immune Status ◽

Immune Dysfunction ◽

Chronic Morphine ◽

T Lymphocyte Proliferation ◽

Proliferation And Differentiation ◽

Opioid Withdrawal Syndrome

In a previous paper we reported that electroacupuncture (EA) could suppress opioid withdrawal syndrome and increase the appetite, sleep, and body weight in heroin addicts or morphine dependent animals. Considering that opioids were known to inhibit immune function, the present study was designed to observe whether EA could modulate the immune status of morphine dependent and withdrawal mice. We found that chronic morphine-induced decrease of splenic T lymphocyte proliferation and IL-2 production can be significantly raised by 2 Hz EA, and the fluctuation of CD4+/CD8+ratio was also run to the baseline level by the EA. These findings indicated that chronic morphine exposure-induced immune dysfunction in mice could be normalized by 2 Hz EA.

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Differentiation of erythroid progenitor (CFU-E) cells from mouse fetal liver cells and murine erythroleukemia (TSA8) cells without proliferation.

Molecular and Cellular Biology ◽

10.1128/mcb.8.6.2604 ◽

1988 ◽

Vol 8 (6) ◽

pp. 2604-2609 ◽

Cited By ~ 9

Author(s):

T Noguchi ◽

H Fukumoto ◽

Y Mishina ◽

M Obinata

Keyword(s):

Colony Formation ◽

Fetal Liver ◽

Liver Cells ◽

Erythroid Progenitor ◽

Erythroid Progenitor Cells ◽

Proliferation And Differentiation ◽

Erythroleukemia Cell ◽

Fetal Liver Cells ◽

Murine Erythroleukemia

Erythropoietin (epo) appears to play a significant role in influencing the proliferation and differentiation of erythroid progenitor (CFU-E) cells. To determine the mechanism of action of epo, the effect of drugs on the in vitro colony formation of CFU-E cells induced from a novel murine erythroleukemia cell line, TSA8, was examined. While cytosine arabinoside inhibited colony formation and terminal differentiation of the CFU-E cells responding to epo, herbimycin, which is a drug that inhibits src-related phosphorylation, inhibited colony formation only. The same effect of herbimycin was observed with normal CFU-E cells from mouse fetal liver cells. These results suggest that epo induces two signals, one for proliferation and the other for differentiation, and that the two signals are not linked in erythroid progenitor cells.

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