Retinal pigment epithelial cells activate uveitogenic T cells when they express high levels of MHC class II molecules, but inhibit T cell activation when they express restricted levels

2003 ◽  
Vol 144 (1-2) ◽  
pp. 1-8 ◽  
Author(s):  
D Sun
Keyword(s):  
T Cells ◽  
Mhc Class Ii ◽  
T Cell Activation ◽  
Cell Activation ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Pigment Epithelial ◽  
Pigment Epithelial Cells ◽  
Mhc Class Ii Molecules

Retinal pigment epithelial cells upregulate expression of complement factors after co-culture with activated T cells

2011 ◽  
Vol 92 (3) ◽  
pp. 180-188 ◽  
Author(s):  
Helene B. Juel ◽  
Charlotte Kaestel ◽  
Lasse Folkersen ◽  
Carsten Faber ◽  
Niels H.H. Heegaard ◽  
...  
Keyword(s):  
T Cells ◽  
Epithelial Cells ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Activated T Cells ◽  
Complement Factors ◽  
Pigment Epithelial ◽  
Pigment Epithelial Cells

scholarly journals Role of Nuclear Factor of Activated T Cells (NFAT) Pathway in Regulating Autophagy and Inflammation in Retinal Pigment Epithelial Cells

2021 ◽  
Vol 22 (16) ◽  
pp. 8684
Author(s):  
Hsuan-Yeh Pan ◽  
Ashley V. Ladd ◽  
Manas R. Biswal ◽  
Mallika Valapala
Keyword(s):  
T Cells ◽  
Epithelial Cells ◽  
Retinal Pigment Epithelial ◽  
Luciferase Activity ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Nuclear Factor ◽  
Activated T Cells ◽  
Pigment Epithelial ◽  
Pigment Epithelial Cells

Nuclear factor of activated T cells (NFAT) family of transcription factors are substrates of calcineurin and play an important role in integrating Ca2+ signaling with a variety of cellular functions. Of the five NFAT proteins (NFAT1-5), NFAT1-4 are subject to dephosphorylation and activation by calcineurin, a Ca2+-calmodulin-dependent phosphatase. Increased levels of intracellular Ca2+ activates calcineurin, which in turn dephosphorylates and promotes nuclear translocation of NFAT. We investigated the functions of NFAT proteins in the retinal pigment epithelial cells (RPE). Our results show that NFAT-mediated luciferase activity was induced upon treatment with the bacterial endotoxin, lipopolysaccharide (LPS) and treatment with the NFAT peptide inhibitor, MAGPHPVIVITGPHEE (VIVIT) decreased LPS-induced NFAT luciferase activity. LPS-induced activation of NFAT-regulated cytokines (IL-6 and IL-8) is inhibited by treatment of cells with VIVIT. We also investigated the effects of NFAT signaling on the autophagy pathway. Our results show that inhibition of NFAT with VIVIT in cells deprived of nutrients resulted in cytosolic retention of transcription Factor EB (TFEB), decreased expression of TFEB-regulated coordinated Lysosomal Expression and Regulation CLEAR network genes and decreased starvation-induced autophagy flux in the RPE cells. In summary, these studies suggest that the NFAT pathway plays an important role in the regulation of autophagy and inflammation in the RPE.

Human Retinal Pigment Epithelial Cells Inhibit Proliferation and IL2R Expression of Activated T Cells

2002 ◽  
Vol 74 (5) ◽  
pp. 627-637 ◽  
Author(s):  
Charlotte G. KÆstel ◽  
Annette JØrgensen ◽  
Mette Nielsen ◽  
Karsten W. Eriksen ◽  
Niels Ødum ◽  
...  
Keyword(s):  
T Cells ◽  
Epithelial Cells ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Activated T Cells ◽  
Pigment Epithelial ◽  
Pigment Epithelial Cells

Impaired Killing of HCMV-Infected Retinal Pigment Epithelial Cells by Anti-pp65 CD8+Cytotoxic T Cells

2003 ◽  
Vol 44 (2) ◽  
pp. 665 ◽  
Author(s):  
Sophie Allart ◽  
Jacqueline Lule´ ◽  
Brigitte Serres ◽  
Thomas Jones ◽  
Jean-Luc Davignon ◽  
...  
Keyword(s):  
T Cells ◽  
Epithelial Cells ◽  
Retinal Pigment Epithelial ◽  
Cytotoxic T Cells ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Pigment Epithelial ◽  
Pigment Epithelial Cells
Sign in / Sign up

Export Citation Format

Share Document