Triple helix formation and the antigene strategy for sequence-specific control of gene expression

1999 ◽  
Vol 1489 (1) ◽  
pp. 181-206 ◽  
Author(s):  
D. Praseuth ◽  
A.L. Guieysse ◽  
C. Hélène
Keyword(s):  
Gene Expression ◽  
Triple Helix ◽  
Control Of Gene Expression ◽  
Helix Formation ◽  
Triple Helix Formation ◽  
Antigene Strategy ◽  
Specific Control

scholarly journals Inhibition of Gene Expression by Triple Helix Formation in Hepatoma Cells

1995 ◽  
Vol 270 (47) ◽  
pp. 28402-28407 ◽  
Author(s):  
Guang-Chou Tu ◽  
Qing-Na Cao ◽  
Yedy Israel
Keyword(s):  
Gene Expression ◽  
Triple Helix ◽  
Hepatoma Cells ◽  
Helix Formation ◽  
Triple Helix Formation

scholarly journals Triplex Forming Oligonucleotides – Tool for Gene Targeting

2004 ◽  
Vol 47 (3) ◽  
pp. 151-156 ◽  
Author(s):  
Martin Mojžíšek
Keyword(s):  
Triple Helix ◽  
Genetic Defect ◽  
Transcriptional Level ◽  
Gene Repair ◽  
Therapeutic Tool ◽  
Helix Formation ◽  
Double Stranded Dna ◽  
Triple Helix Formation ◽  
Inhibit Gene Expression ◽  
Antigene Strategy

This review deals with the antigene strategy whereby an oligonucleotide binds to the major or minor groove of double helical DNA where it forms a local triple helix. Preoccupation of this article is triplex-forming oligonucleotides (TFO). These are short, synthetic single-stranded DNAs that recognize polypurine:polypyrimidine regions in double stranded DNA in a sequence-specific manner and form triplex. Therefore, the mechanisms for DNA recognition by triple helix formation are discussed, together with main characteristics of TFO and also major obstacles that remain to be overcome are highlighted. TFOs can selectively inhibit gene expression at the transcriptional level or repair genetic defect by direct genome modification in human cells. These qualities makes TFO potentially powerful therapeutic tool for gene repair and/or expression regulation.

scholarly journals A physico-chemical study of triple helix formation by an oligodeoxythymidylate with N3'->P5' phosphoramidate linkages

1997 ◽  
Vol 25 (9) ◽  
pp. 1782-1787 ◽  
Author(s):  
B.-w. Zhou-Sun ◽  
J. Liquier ◽  
E. Taillandier ◽  
J.-s. Sun ◽  
T. Garestier ◽  
...  
Keyword(s):  
Triple Helix ◽  
Chemical Study ◽  
Helix Formation ◽  
Physico Chemical ◽  
Triple Helix Formation
Sign in / Sign up

Export Citation Format

Share Document