Bibliometric mapping of techno-scientific systems of small Latin American worlds

Purpose The purpose of this study was to compare the evolution of the scientific production of Costa Rica and Panama, from Central America and Paraguay and Uruguay, from South America in the period 2000–2018. To achieve this, first, a bibliometric mapping was performed using the Web of Science (WoS) database. Second, the triple helix model was used to determine whether there are similar patterns or marked differences in the distribution of this type of publications in the helices of government, academia and industry. Design/methodology/approach The steps followed in this study were as follows: design and application of an algorithm to perform WoS downloads; download the publications using the country descriptor; process data using R and VOSviewer; design of a profile of the selected countries based on indicators; and use of the triple helix model to determine the weight of the scientific production. Findings The data found corroborate that the small technoscientific worlds examined do not have the minimum Science & Technology personnel nor the capabilities in infrastructure and technological equipment, and that expenditure in this area is minimal and for these reasons, the production in the WoS is low. Originality/value Studying the small technoscientific worlds from a bibliometric perspective allows generating inputs to diagnose the state of these countries in this area, as no evidence of similar studies in these countries was found in Scopus or the WoS. Likewise, examining scientific production from the triple helix model makes it possible to identify the weaknesses of each actor, and the results can contribute to the design of better public policies.

Analisis Model Tripel Helix Dalam Pengembangan Ekonomi (Studi Pada IKM Kerajinan Perak Mojokerto)

Creative economy development aims to develop human resources so that they can compete with reliable quality. Rural areas, especially the Batankrajan Village area, are one of the areas in Mojokerto Regency that have the potential of creative human resources to improve the welfare of the local community. Batankrajan village and is the center of the silver industry which is quite potential as a competitive product and Mojokerto's leading commodity. The aims of this study were (1) to identify the conditions and needs for product development and market development of the craftsmen/performers of the silver craft business in Senta Batankrajan, Mojokerto, East Java, (2) to identify the problems faced by the craftsmen of silver crafts IKM in Mojokerto, East Java, especially in increasing competitiveness, (3) Analyzing the triple helix model in the development of the creative economy as a driving force for Mojokerto silver handicraft products to increase local innovative and creative products that are unique to the region and have high added value and are able to become regional icons. This research also identifies strengths, weaknesses, opportunities and threats that can be used as information to map the strengths and weaknesses of creative industry players so that strategies for developing the right Triple helix model can be formulated for business actors. This research produces an economic/creative industry model with a Triple helix approach that provides a role for stakeholders (government, universities and business actors) in advancing the creative industry in rural areas, especially the silver industry in the center of Batankrajan, Mojokerto. Several recommendations and the framework for developing the Triple Helix model in the development of the creative economy include: Institutional strengthening, through Joint Business Groups, in order to invest in product development and market penetration as well as facilitate the establishment of access to financial sources and market access, the creation and establishment of intensive communication between government, universities and creative industry players, as well as the establishment of community forums that involve the government, universities in the Mojokerto area and do not rule out universities outside Mojokerto as well as industry players that function as communication forums and as a means of coaching and training.

Triple-helix potential of the mouse genome

Certain DNA sequences, including mirror-symmetric polypyrimidine/polypurine runs, are capable of folding into a triple-helix-containing non-B-form DNA structure called H-DNA. Such H-DNA-forming sequences are frequent in many eukaryotic genomes, including in mammals, and multiple lines of evidence indicate that these motifs are mutagenic and can impinge on DNA replication, transcription, and other aspects of genome function. In this study, we show that the triplex-forming potential of H-DNA motifs in the mouse genome can be evaluated using S1-sequencing (S1-seq), which uses the single-stranded DNA (ssDNA)-specific nuclease S1 to generate deep-sequencing libraries that report on the position of ssDNA throughout the genome. When S1-seq was applied to genomic DNA isolated from mouse testis cells and splenic B cells, we observed prominent clusters of S1-seq reads that appeared to be independent of endogenous double-strand breaks, that coincided with H-DNA motifs, and that correlated strongly with the triplex-forming potential of the motifs. Fine-scale patterns of S1-seq reads, including a pronounced strand asymmetry in favor of centrally-positioned reads on the pyrimidine-containing strand, suggested that this S1-seq signal is specific for one of the four possible isomers of H-DNA (H-y5). By leveraging the abundance and complexity of naturally occurring H-DNA motifs across the mouse genome, we further defined how polypyrimidine repeat length and the presence of repeat-interrupting substitutions modify the structure of H-DNA. This study provides a new approach for studying DNA secondary structure genome wide at high spatial resolution.

Inovasi dan Daya Saing UMKM di Era New Normal: dari Triple Helix Model ke Quadruple Helix Model

The role of MSMEs in the economic development of a country has important implications for increasing income, reducing unemployment, alleviating poverty and economic growth. The Covid-19 pandemic has had a negative impact and threatened the survival of MSMEs. This study aims to analyze the dynamics of the triple helix model by examining the role of each helix: universities, companies, and governments to help MSMEs rise from adversity. This study identifies behavioral profiles in terms of the performance of the triple helix model from the perspective of MSMEs and recognizes key factors for innovation success and competitiveness. The survey involved 134 MSMEs. The analysis method uses SEM-PLS with WarpPLS07. The results of the study indicate that there is a positive influence between the synergy of the government and academia in increasing the innovation and competitiveness of MSMEs. Innovation is able to become a mediator for the synergy of the government and academia in increasing the competitiveness of MSMEs. MSMEs need to be more active and proactive, the role of the government and academics still needs to be improved and coupled with the optimal role of other helixes, especially the community as a strategy to survive and thrive in the Covid-19 pandemic situation.

Ablation of the FACIT collagen XII disturbs musculoskeletal ECM organization and causes patella dislocation and myopathy

Collagen XII, belonging to the fibril-associated collagens with interrupted triple helix (FACIT) family, assembles from three identical α-chains encoded by the COL12A1 gene. The trimeric molecule consists of three N-terminal noncollagenous NC3 domains joined by disulfide bonds followed by a short interrupted collagen triple helix at the C-terminus. Collagen XII is expressed widely in the musculoskeletal system and mutations in the COL12A1 gene cause an Ehlers-Danlos/myopathy overlap syndrome, which is associated with skeletal abnormalities and muscle weakness. Our study defines the role of collagen XII in patella development using the Col12a1-/- mouse model. Deficiency in Col12a1 expression causes malformed facies patellaris femoris grooves at an early stage, which leads to patella subluxation and growth retardation. Due to the patella subluxation, more muscle fibers with centralized nuclei occur in the quadriceps than in the gastrocnemius muscles indicating a local effect. To further understand the role of collagen XII in the skeletal tissues single cell RNAseq (scRNA-seq) was performed. Comparison of the gene expression in the tenocyte cell sub-population of wild type and Col12a1-/- mice showed that several matrix genes are altered. Finally, we reinvestigated collagen XII deficient patients and observed a patella instability.

Understanding of Global Citizenship among Higher Education Teachers: Implications for Graduate Attributes

Global Citizenship (GC) has recently claimed its position as desired graduates’ attribute in many Higher Education (HE) institutions in different non-Western contexts. However, ambiguity and complexity still linger over what GC means contextually and how this understanding may shape educational outcomes. Taking cognizance of this, a study was carried out to investigate the understanding of GC among Vietnamese HE teachers as major agents in Global Citizenship Education (GCE), in order to discuss their implications for graduate attributes. This study adopted purposeful sampling strategy to conduct in-depth interviews among 14 teachers from 4 different faculties of a private university in Southern Vietnam. Emergent themes were then compared with GC conceptions theorized in the literature. Data analysis revealed a three-fold dimensions in teachers’ perception: (1) GC understanding was ambiguous and divergent and uniquely nuanced by personal and contextual factors, (2) triple helix of GC conceptions were intricately entwined in GCE rationales, and (3) GC notion was framed with juxtapositions of conceptions. The findings highlighted an implementation gap in GCE which might subvert the intended educational aim, especially in the context of unavailable official documents to guide GCE. In this way, the paper contributes to the ongoing discussion regarding GCE implementation, and indicates a need to have clearer instructional GCE-related policies and more comprehensive teacher trainings.