Resting right ventricular function in patients with coronary artery disease: pressure volume analysis using conductance catheters

1997 ◽  
Vol 58 (3) ◽  
pp. 223-228 ◽  
Author(s):  
A Bishop ◽  
P White ◽  
R Chaturvedi ◽  
C Brookes ◽  
A Redington ◽  
...  
2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Hafeez Ul Hassan Virk ◽  
Muhammad Bilal Munir

Objective.Preventing the morbidity and mortality from isolated right ventricular myocarditis by its early recognition and treatment.Background. The clinical presentation of myocarditis ranges from nonspecific systemic symptoms (fever, myalgia, palpitations, or exertional dyspnea) to fulminant cardiac failure and sudden death. In our case, echocardiography raised the possibility of myocarditis at an early stage, although the signs and symptoms did not indicate right ventricular disease. Review of the literature showed only 4 previous reports, all diagnosed at autopsy, in which diagnosis was not suspected in vivo.Design/Methods. We are reporting case of a 23-year-old male with no past medical history who presented to emergency room with a nonexertional sharp left sided chest pain. Diagnostic tests were conducted, which revealed elevated troponins, decreased right ventricular ejection function but preserved left ventricular function, and no evidence of coronary artery disease.Results. A diagnosis of isolated right ventricular myocarditis was made on the basis of clinical, echocardiographic, and cardiac MRI findings.Conclusions. Isolated right ventricular myocarditis should be suspected in a patient with depressed right ventricular function without left ventricular involvement on echocardiography and cardiac MRI, elevated cardiac enzymes, and no evidence of coronary artery disease.


2020 ◽  
pp. 021849232097289
Author(s):  
Dhanesh Kumar ◽  
Om Prakash Yadava ◽  
Vikas Ahlawat ◽  
Anirban Kundu ◽  
Amita Yadav ◽  
...  

Background Levosimendan is an effective calcium sensitizer with complementary mechanisms of action: calcium sensitization and opening of adenosine triphosphate-dependent potassium channels, both on the sarcolemma of the smooth muscle cells in the vasculature and on the mitochondria of cardiomyocytes. Levosimendan has a long-acting metabolite with a half-life of approximately 80 h. There have been a few small studies on this drug regarding right ventricular function. In view of this, we investigated the effect of levosimendan on right ventricular function in patients with coronary artery disease. Methods This was a prospective, randomized, double-blind study on 50 patients with coronary artery disease and severe left ventricular dysfunction (left ventricular ejection fraction ≤35%) undergoing elective off-pump coronary artery bypass. Results Levosimendan had an inotropic effect on right ventricular myocardium and a vasodilatory effect on blood vessels. It caused a decline in pulmonary vascular resistance ( p < 0.018), right ventricular systolic pressure ( p < 0.001), and pulmonary artery systolic pressure ( p < 0.001), and improved right ventricular diastolic function as shown by the decrease in right ventricular Tei index ( p < 0.001), right ventricular end-diastolic pressure, and the ratio of early diastolic tricuspid inflow to tricuspid lateral annular velocity ( p < 0.006). However, we found no beneficial effects on intensive care unit or hospital stay ( p = 0.164, p = 0.349, respectively) nor a mortality benefit. Conclusions Levosimendan has salutary effects on right ventricular function in patients with severe left ventricular dysfunction undergoing coronary artery bypass, in terms of improved hemodynamic parameters.


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