High-dose streptokinase therapy for prosthetic valve thrombosis within 2 weeks of open heart surgery

1998 ◽  
Vol 66 (2) ◽  
pp. 143-145
Author(s):  
B Bhargava ◽  
A.K Chopra ◽  
R Agarwal ◽  
R Narang ◽  
V Chopra ◽  
...  
Keyword(s):  
Prosthetic Valve ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
High Dose ◽  
Open Heart ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis ◽  
Streptokinase Therapy

Spinal Anesthesia with an Indwelling Catheter Reduces the Stress Response in Pediatric Open Heart Surgery

2005 ◽  
Vol 103 (6) ◽  
pp. 1113-1120 ◽  
Author(s):  
Nigel Humphreys ◽  
Simon M. Bays ◽  
Andrew J. Parry ◽  
Ashwinikumar Pawade ◽  
Robert S. Heyderman ◽  
...  
Keyword(s):  
Young Children ◽  
Spinal Anesthesia ◽  
Stress Responses ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Plasma Norepinephrine ◽  
High Dose ◽  
Open Heart ◽  
Extreme Stress ◽  
Infants And Young Children

Background Extreme stress and inflammatory responses to open heart surgery are associated with increased morbidity and mortality. Based on both animal and adult human data, it was hypothesized that spinal anesthesia would be more effective at attenuating these responses than conventional high dose intravenous opioid techniques in infants and young children undergoing open heart surgery. Methods A prospective randomized controlled clinical trial was performed in 60 children aged up to 24 months undergoing open heart surgery. Patients were randomly assigned to receive either high-dose intravenous opioid or high-dose intravenous opioid plus spinal anesthesia. Spinal anesthesia was administered via an indwelling intrathecal catheter. Results Spinal anesthesia significantly reduced the stress responses as measured by plasma norepinephrine and epinephrine concentrations (both P < 0.05). Spinal anesthesia reduced plasma lactate concentrations (P < 0.05), but increased fluid requirements during the first postoperative day (P < 0.05). There were no differences in other cardiovascular parameters. Conclusions Continuous spinal anesthesia reduces stress responses in infants and young children undergoing cardiac surgery with cardiopulmonary bypass more effectively than high-dose intravenous opioids alone.

Effect of High-Dose Ampicillin and Cloxacillin on Bleeding Time and Bleeding in Open-Heart Surgery

1985 ◽  
Vol 19 (1) ◽  
pp. 45-48 ◽  
Author(s):  
Johan Pillgram-Larsen ◽  
Finn Wisløff ◽  
JØRgen J. Jørgensen ◽  
Hans Chr. Godal ◽  
Gudmund Semb
Keyword(s):  
Heart Surgery ◽  
Bleeding Time ◽  
Open Heart Surgery ◽  
High Dose ◽  
Open Heart

scholarly journals Prosthetic valve thrombosis during extracorporeal life support for postcardiotomy shock

2020 ◽  
Vol 31 (4) ◽  
pp. 573-575
Author(s):  
Andrew Melehy ◽  
Joseph Sanchez ◽  
Justin A Fried ◽  
Koji Takeda
Keyword(s):  
Prosthetic Valve ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Open Heart Surgery ◽  
Initial Flow ◽  
Prosthetic Valve Thrombosis ◽  
Prosthetic Valves ◽  
Valve Thrombosis ◽  
Postcardiotomy Shock ◽  
Central Cannulation

Abstract Postcardiotomy shock is a complication after open-heart surgery that may be alleviated with extracorporeal life support (ECLS). Postcardiotomy shock patients on ECLS with prosthetic valves are at a high risk of valve thrombosis. We retrospectively reviewed patients supported with ECLS after the development of postcardiotomy shock at our centre, 90 of which had prosthetic valves. Nine patients developed prosthetic valve thrombosis, an incidence of 10%. Patients who developed prosthetic valve thrombosis were more often supported via central cannulation (78% vs 38%, P = 0.034) and had a higher median initial flow (4.4 vs 3.2 l/min, P = 0.018). Central cannulation was associated with valve thrombosis by multivariable logistic regression (odds ratio 7.56; 95% confidence interval 1.12–149.87). Central cannulation with high flow is thought to reduce intracardiac blood flow, thereby increasing the risk of stasis and thrombus formation. Patients with prosthetic valve thrombosis were treated with anticoagulation or surgical intervention and 4 patients (44%) survived to discharge.

Post-transfusion purpura following open heart surgery: management by high dose intravenous immunoglobulin infusion

1988 ◽  
Vol 57 (5) ◽  
pp. 323-325 ◽  
Author(s):  
W. S. Walker ◽  
P. L. Yap ◽  
D. C. Kilpatrick ◽  
F. E. Boulton ◽  
R. J. Crawford ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
High Dose ◽  
Open Heart ◽  
Surgery Management
Sign in / Sign up

Export Citation Format

Share Document