Acute and chronic phase platelet aggregability studies in Chinese patients after implantation of a permanent transvenous pacemaker

Abstract ABSTRACT Purpose: The aim of this study was to characterize the different stages of non-arteritic anterior inschemic optic neuropathy (NAION) features by Fundus Photography (FP) and Fluorescein Aniography (FA) in a Chinese Population. Methods: The retrospective observation study included 30 patients (36 eyes) with acute phase, 20 patients (27 eyes) with subacute phase and 30 patients (52 eyes) with chronic phase. Macular, optic nerve and disc were investigated by FP and FA. Categorical variables were evaluated by Fisher’s exact test. Results: Macular edema, papilloedema, disc hemorrhage and exudation from FP were more common in the acute and subacute stage groups than chronic stage group with optic atrophy in contrast (all p<0.01). Compared to chronic stage, acute and subacute stages were more likely to appear macular fluorescence accumulation and peripapillary choroid filling delay (all p<0.01). However, chronic stage tended to have retinal artery filling delay and disc filling defects in the early phase from FA (all p<0.01). Conclusion: The data showed that NAION had different fundus performances at different clinical stages. They may help to record the disease progression for accurate diagnosis and treatment.

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The poor prognostic significance of deletions of derivative chromosome 9 in Chinese patients with chronic myelogenous leukemia

Journal of Clinical Oncology ◽

10.1200/jco.2007.25.18_suppl.17535 ◽

2007 ◽

Vol 25 (18_suppl) ◽

pp. 17535-17535

Author(s):

J. Li ◽

W. Xu ◽

W. Wu ◽

S. Zhang ◽

Y. Zhu

Keyword(s):

Fusion Gene ◽

Hematologic Malignancy ◽

Blast Crisis ◽

Prognostic Significance ◽

Chronic Phase ◽

Chromosome 9 ◽

Myelogenous Leukemia ◽

Chinese Patients ◽

Striking Difference ◽

Derivative Chromosome

17535 Background: Chronic myeloid leukemia (CML) is characterized by formation of the BCR/ABL fusion gene, usually as a consequence of the Philadelphia (Ph) translocation between chromosomes 9 and 22. Deletions of the derivative 9 chromosome [der(9)] in 10- 15% of CML patients with a standard Ph translocation and in >30% of CML patients with a variant Ph translocation. Subsequent studies demonstrated that CML patients who carry a der(9) deletion progress more rapidly to blast crisis and have a shorter survival than those without a deletion. The characteristics of Chinese patients with each hematologic malignancy compared with those in other countries have not yet been clarified. This prompted us to perform molecular and cytogenetic analyses on Chinese patients with CML. Methods: To study the incidence and the prognostic significance of the derivative chromosome 9 [der(9)] deletions in on Chinese patients with CML, a series of 48 BCR/ABL positive Chinese CML blast crisis (CML-BC) patients were investigated using dual colour dual fusion BCR/ABL probe and fluorescence in situ hybridization (FISH). Results: Eight (16.7%) cases showed der(9) deletions, and the deletions were also existed in chromosome preparations made at diagnosis. The estimated median length of chronic phase for patients with der(9) deletions was 18 months (range 4–38 months) compared to 48 months (range 0–204 months) for patients without deletions. Kaplan-Meier analysis revealed a striking difference in length of chronic phase between with and without der(9) deletions, and this difference was highly significant by log-rank analysis. Der(9) deletions are not associated with increased karyotypic instability. There was no difference in the probability of the der(9) deletions between the cases transformed to acute nonlymphocytic leukemia (ANLL) and those to acute lymphoid leukemia (ALL). Conclusions: The results indicate that FISH technique could effectively detect the der(9) deletions. Der(9) deletions occur at the time of Ph translocation. CML patients with der(9) deletions have more rapid process and poorer prognosis. Deletion status is a powerful prognostic factor for patients with CML. Der(9) deletions might not lead to transformation to specific type in CML. No significant financial relationships to disclose.

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Seven-year response to imatinib as initial treatment versus re-treatment in Chinese patients with chronic myelogenous leukemia in the chronic phase

Annals of Hematology ◽

10.1007/s00277-010-1031-0 ◽

2010 ◽

Vol 90 (1) ◽

pp. 41-46 ◽

Cited By ~ 6

Author(s):

Hao Jiang ◽

Shan-Shan Chen ◽

Bin Jiang ◽

Qian Jiang ◽

Ya-Zhen Qin ◽

...

Keyword(s):

Chronic Myelogenous Leukemia ◽

Initial Treatment ◽

Chronic Phase ◽

Myelogenous Leukemia ◽

Chinese Patients

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Phase 3 study of nilotinib vs imatinib in Chinese patients with newly diagnosed chronic myeloid leukemia in chronic phase: ENESTchina

Blood ◽

10.1182/blood-2014-09-601674 ◽

2015 ◽

Vol 125 (18) ◽

pp. 2771-2778 ◽

Cited By ~ 53

Author(s):

Jianxiang Wang ◽

Zhi-Xiang Shen ◽

Giuseppe Saglio ◽

Jie Jin ◽

He Huang ◽

...

Keyword(s):

Chronic Myeloid Leukemia ◽

Myeloid Leukemia ◽

Chronic Phase ◽

Chinese Patients ◽

Newly Diagnosed ◽

Phase 3 ◽

Key Points ◽

Safety Signals

Key Points Chinese patients with newly diagnosed CML-CP achieved higher rates of MMR with nilotinib vs imatinib. Nilotinib was well tolerated, and no new safety signals were observed.

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