273 poster Comparison of the treatment plans using 3D-CRT and IMRT for patients enrolled in the dahanca-9 protocol

2003 ◽  
Vol 68 ◽  
pp. S99
Keyword(s):  
Treatment Plans ◽  
3D Crt

scholarly journals Dosimetric Measurement for Isocentre Blocked Boost Fields in 3D-CRT Treatment Plans

2016 ◽  
Vol 118 ◽  
pp. S37
Author(s):  
S. Dwivedi ◽  
R.A. Kinhikar ◽  
C.M. Tambe ◽  
A. Bargundi ◽  
D.D. Deshpande ◽  
...  
Keyword(s):  
Treatment Plans ◽  
3D Crt

10-MV SBRT FFF IRRADIATION TECHNIQUE IS ASSOCIATED TO THE LOWEST PERIPHERAL DOSE: THE OUTCOME OF 142 TREATMENT PLANS FOR THE 10 MOST COMMON TUMOUR LOCATIONS

2019 ◽  
Vol 185 (2) ◽  
pp. 183-195 ◽  
Author(s):  
L Irazola ◽  
B Sánchez-Nieto ◽  
M T García-Hernández ◽  
J A Terrón ◽  
J Roselló ◽  
...  
Keyword(s):  
Analytical Models ◽  
Second Primary ◽  
Dose Delivery ◽  
Peripheral Dose ◽  
Second Primary Cancers ◽  
Flattening Filter Free ◽  
Combined Use ◽  
Treatment Plans ◽  
Flattening Filter ◽  
3D Crt

Abstract There is a growing interest in the combined use of Stereotactic Body Radiation Therapy (SBRT) with Flattening Filter Free (FFF) due to the high local control rates and reduced treatment times, compared to conventionally fractionated treatments. It has been suggested that they may also provide a better radiation protection to radiotherapy patients as a consequence of the expected decrease in peripheral doses. This work aims to determine this reduction in unattended out-of-field regions, where no CT information is available but an important percentage of second primary cancers occur. For that purpose, ten different cases suitable for SBRT were chosen. Thus, 142 different treatment plans including SBRT, as well as 3D‐CRT, IMRT and VMAT (with standard fractionation) in low and high energies for Varian (FF and FFF), Siemens and Elekta machines were created. Then, photon and neutron peripheral dose in 14 organs were assessed and compared using two analytical models. For the prostate case, uncomplicated and cancer free control probability estimation was also carried out. As a general behavior, SBRT plans led to the lowest peripheral doses followed by 3D-CRT, VMAT and IMRT, in this order. Unflattened beams proved to be the most effective in reducing peripheral doses, especially for 10 MV. The obtained results suggest that FFF beams for SBRT with 10 MV represent the best compromise between dose delivery efficiency and peripheral dose reduction.

scholarly journals Pediatric craniospinal irradiation with a short partial-arc VMAT technique for medulloblastoma tumors in dosimetric comparison

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Gerhard Pollul ◽  
Tilman Bostel ◽  
Sascha Grossmann ◽  
Sati Akbaba ◽  
Heiko Karle ◽  
...  
Keyword(s):  
At Risk ◽  
Low Dose ◽  
Organs At Risk ◽  
Treatment Plan ◽  
Volumetric Modulated Arc Therapy ◽  
Conformal Radiotherapy ◽  
Dosimetric Comparison ◽  
Pediatric Medulloblastoma ◽  
Treatment Plans ◽  
3D Crt

Abstract Background This study aimed to contrast four different irradiation methods for pediatric medulloblastoma tumors in a dosimetric comparison regarding planning target volume (PTV) coverage and sparing of organs at risk (OARs). Methods In sum 24 treatment plans for 6 pediatric patients were realized. Besides the clinical standard of a 3D-conformal radiotherapy (3D-CRT) treatment plan taken as a reference, volumetric modulated arc therapy (VMAT) treatment plans (“VMAT_AVD” vs. “noAVD” vs. “FullArc”) were optimized and calculated for each patient. For the thoracic and abdominal region, the short partial-arc VMAT_AVD technique uses an arc setup with reduced arc-length by 100°, using posterior and lateral beam entries. The noAVD uses a half 180° (posterior to lateral directions) and the FullArc uses a full 360° arc setup arrangement. The prescription dose was set to 35.2 Gy. Results We identified a more conformal dose coverage for PTVs and a better sparing of OARs with used VMAT methods. For VMAT_AVD mean dose reductions in organs at risk can be realized, from 16 to 6.6 Gy, from 27.1 to 8.7 Gy and from 8.0 to 1.9 Gy for the heart, the thyroid and the gonads respectively, compared to the 3D-CRT treatment method. In addition we have found out a superiority of VMAT_AVD compared to the noAVD and FullArc trials with lower exposure to low-dose radiation to the lungs and breasts. Conclusions With the short partial-arc VMAT_AVD technique, dose exposures to radiosensitive OARS like the heart, the thyroid or the gonads can be reduced and therefore, maybe the occurrence of late sequelae is less likely. Furthermore the PTV conformity is increased. The advantages of the VMAT_AVD have to be weighed against the potentially risks induced by an increased low dose exposure compared to the 3D-CRT method.

Comparing treatment plans for stomach cancer: three-dimensional conformal radiotherapy (3D-CRT), physical wedge-based conformal RT (WB-CRT) and intensity-modulated radiotherapy (IMRT)

2021 ◽  
pp. 1-6
Author(s):  
Gokcen Inan ◽  
Osman Vefa Gul
Keyword(s):  
Spinal Cord ◽  
Stomach Cancer ◽  
Organs At Risk ◽  
Left Kidney ◽  
Three Dimensional ◽  
Conformal Radiotherapy ◽  
Conformity Index ◽  
Intensity Modulated ◽  
Treatment Plans ◽  
3D Crt

Abstract Objective: The aim of this study was to find the optimal radiotherapy (RT) method using three-dimensional (3D) conformal RT (CRT), physical wedge-based CRT (WB-CRT) and dynamic intensity-modulated RT (D-IMRT) techniques for stomach cancer. Methods: Ten patients with gastric cancer were selected for this study. For each patient, three different treatment plans were generated. 3D-CRT, WB-CRT and IMRT plans were evaluated in terms of dosimetry. Treatment plans were compared with respect to the planning target volume and organs at risk (OARs) volumes including right and left kidney doses (V13, V20 and V28), heart mean and maximum doses, spinal cord maximum doses, dose homogeneity index, conformity index (CI), delivery time and the monitor unit counts for the treatment. Statistical analysis was performed using the SPSS (Statistical Package for the Social Sciences) v25.1 software (IBM Inc., Chicago, IL, USA). Results: In stomach plans, IMRT showed a significantly lower dose for the left and right kidneys than that of WB-CRT or 3D-CRT (p < 0·05). Compared with WB-CRT or 3D-CRT, IMRT reduced the V28, V20, V13 and mean dose to bilateral kidneys (p < 0·05). IMRT plans indicated better dosimetry for at the Dmean of the liver and heart. Concerning the calculated CI, values for IMRT plans gave significant results than other plans (p < 0·05). Conclusions: IMRT plans provided better protection for the kidneys, liver, heart and spinal cord. For the treatment of stomach cancer, considering the dose to the OARs, IMRT appears to be the most superior technique.

scholarly journals Intensity Modulated and Three-Dimensional Conformal Radiation Therapy Plans for Oropharyngeal Cancer: A Comparison of Their Sensitivity to Set-Up Errors and Uncertainties

2011 ◽  
Vol 13 (2) ◽  
pp. 61-66
Author(s):  
N. Ploquin ◽  
H. Lau ◽  
P. Dunscombe
Keyword(s):  
Radiation Therapy ◽  
Radiation Therapy Oncology Group ◽  
Three Dimensional ◽  
Imrt Plan ◽  
Data Set ◽  
Conformal Radiation Therapy ◽  
Intensity Modulated ◽  
Treatment Plans ◽  
Set Up ◽  
3D Crt

We compared the effect of set-up error and uncertainty on two radiation therapy treatment plans for head and neck cancer: one using intensity modulated radiation therapy (IMRT) and one using conventional three-dimensional conformal radiation therapy (3D-CRT). We used a Pinnacle3 (Philips Medical Systems, Markham, Ontario) system to create the two treatment plans (7-beam IMRT and 5-beam 3D-CRT) for the same volumetric data set, based on the objectives and constraints defined in the Radiation Therapy Oncology Group H-0022 protocol. In both plans, the dose–volume constraints for the targets and the organs at risk (OARS) were met as closely as the beam geometries would allow. Monte Carlo–based simulations of set-up error and uncertainty were performed in three orthogonal directions for 840 simulated “courses of treatment” for each plan. A systematic error (chosen from distributions characterized by standard deviations ranging from 0 mm to 6 mm) and random uncertainties (2 mm standard deviation) were incorporated. We used a probability approach to compare the sensitivities of the IMRT and the 3D-CRT plans to set-up error and uncertainty in terms of equivalent uniform dose (EUD) to targets and OARS. Based on the EUD analysis, the targets and OARS showed considerably greater sensitivity to set-up error with the IMRT plan than with the 3D-CRT plan. For the IMRT plan, target EUDS were reduced by 4%, 7.5%, and 10% for 2-mm, 4-mm, and 6-mm set-up errors respectively. However, even with set-up error, the mandible, spinal cord, and parotid EUDS always remained lower with the IMRT plan than with the 3D-CRT plan. We conclude that, when quantified by EUD, IMRT plan doses to OARS and targets are more sensitive to set-up error than are 3D-CRT-plan doses. However, as judged by the differences between target and OAR doses, IMRT retains its superiority over 3D-CRT, even in the presence of set-up error.

Advantage of Deep Inspiration Breath Hold in Left-sided Breast Cancer Patients Treated with 3D Conformal Radiotherapy

2016 ◽  
Vol 103 (1) ◽  
pp. 72-75 ◽  
Author(s):  
Luciana Lastrucci ◽  
Simona Borghesi ◽  
Silvia Bertocci ◽  
Chiara Gasperi ◽  
Andrea Rampini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Left Lung ◽  
Conformal Radiotherapy ◽  
Breath Hold ◽  
Deep Inspiration ◽  
Breast Cancer Patients ◽  
Deep Inspiration Breath Hold ◽  
Treatment Plans ◽  
3D Crt

Purpose To compare 3D-conformal radiotherapy (3D-CRT) treatment plans based on free-breathing (FB) and deep inspiration breath hold (DIBH) and investigated whether DIBH technique enables a decrease of cardiac left anterior descending coronary artery (LADCA) and lungs dose with respect to the FB. Methods Twenty-three left-sided breast cancer patients referred for breast radiotherapy were included. The planning target volume (PTV) encompassed the breast and organs at risk including heart, LADCA, lungs, and contralateral breast, which were contoured in FB and DIBH CT scans. Dose to PTV was 50 Gy in 25 fractions. Two treatment plans were generated for each patient: FB-3D-CRT and DIBH-3D-CRT. Dosimetry parameters were obtained from dose volume histograms. Data were compared using the paired-sample Wilcoxon signed rank test. Results For heart, LADCA, and left lung, a significant dose reduction was found using DIBH technique. By using DIBH, an average reduction of 25% was observed in LADCA for the volume receiving 20 Gy and of 48% considering the mean heart dose. Conclusions The DIBH technique results in a significant decrease of dose to the heart, LADCA, and left lung compared to FB.

SU-FF-T-317: Measured and Simulated Non-Target Whole-Body Doses for Selected IMRT and 3D-CRT Treatment Plans

2006 ◽  
Vol 33 (6Part11) ◽  
pp. 2119-2119
Author(s):  
B Bednarz ◽  
X George Xu ◽  
B Wang
Keyword(s):  
Whole Body ◽  
Treatment Plans ◽  
3D Crt

scholarly journals Hybrid volumetric modulated arc therapy for hypofractionated radiotherapy of breast cancer: a treatment planning study

2020 ◽  
Author(s):  
Alexander Venjakob ◽  
Michael Oertel ◽  
Dominik Alexander Hering ◽  
Christos Moustakis ◽  
Uwe Haverkamp ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Negative Impact ◽  
Organs At Risk ◽  
Volumetric Modulated Arc Therapy ◽  
Breath Hold ◽  
Deep Inspiration Breath Hold ◽  
Mixed Beam ◽  
Arc Therapy ◽  
Treatment Plans ◽  
3D Crt

Abstract Purpose This study aims to evaluate the best possible practice using hybrid volumetric modulated arc therapy (H-VMAT) for hypofractionated radiation therapy of breast cancer. Different combinations of H‑VMAT—a combination of three-dimensional radiotherapy (3D-CRT) and VMAT—were analyzed regarding planning target volume (PTV), dose coverage, and exposure to organs at risk (OAR). Methods Planning computed tomography scans were acquired in deep-inspiration breath-hold. A total of 520 treatment plans were calculated and evaluated for 40 patients, comprising six different H‑VMAT plans and a 3D-CRT plan as reference. H‑VMAT plans consisted of two treatment plans including 3D-CRT and VMAT. During H‑VMAT planning, the use of hard wedge filters (HWF) and beam energies were varied. The reference plans were planned with mixed beam energies and the inclusion/omission of HWF. Results Compared to the reference treatment plans, all H‑VMAT plans showed consistently better PTV dose coverage, conformity, and homogeneity. Additionally, OAR protection was significantly improved with several H‑VMAT combinations (p < 0.05). The comparison of different H‑VMAT combinations showed that inclusion of HWF in the base plan had a negative impact on PTV dose coverage, conformity, and OAR exposure. It also increased the planned monitor units and beam-on time. Advantages of using lower beam energies (6-MV photons) in both the base plan and in the VMAT supplementary dose were observed. Conclusion The H‑VMAT technique is an effective possibility for generating homogenous and conformal dose distributions. With the right choice of H‑VMAT combination, superior OAR protection is achieved compared to 3D-CRT.

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