674 poster Pretreatment volumetric assessment of major salivary glands in head and neck cancer patients

2004 ◽  
Vol 73 ◽  
pp. S293-S294
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Salivary Glands ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Major Salivary Glands ◽  
Volumetric Assessment

scholarly journals Reducing Xerostomia by Comprehensive Protection of Salivary Glands in Intensity-Modulated Radiation Therapy with Helical Tomotherapy Technique for Head-and-Neck Cancer Patients: A Prospective Observational Study

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Feng Teng ◽  
Wenjun Fan ◽  
Yanrong Luo ◽  
Zhongjian Ju ◽  
Hanshun Gong ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Salivary Glands ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Helical Tomotherapy ◽  
Clinical Stage ◽  
Flow Rates ◽  
Saliva Flow

Objective. This study aimed to analyze the effects of comprehensive protection of bilateral parotid glands (PG-T), contralateral submandibular gland (cSMG), and accessory salivary glands in the oral cavity (OC) by helical tomotherapy for head-and-neck cancer patients. Methods. Totally 175 patients with histologically confirmed head-and-neck cancer treated with helical tomotherapy were recruited. The doses delivered to PG-T, cSMG, and OC were constrained to be as low as possible in treatment planning. The saliva flow rates and xerostomia questionnaire were evaluated. Correlation between xerostomia and other clinical factors were assessed using univariate and multivariate models. The impact of salivary gland dose on locoregional (LR) recurrence was assessed by Cox analysis. ROC curve was used to determine the threshold of mean dose for each gland. Results. The median follow-up was 25 (19–36) months. The OC mean dose, PG-T mean dose, cSMG mean dose, age, clinical stage (II and III versus IV), and both unstimulated and stimulated saliva flow rates were significantly correlated with xerostomia. The OC mean dose, cSMG mean dose, age, and clinical stage were predictors of xerostomia after adjusting PG-T mean dose, and unstimulated and stimulated saliva flow rates. Xerostomia was significantly decreased when the mean doses of PG-T, cSMG, and OC were kept below 29.12Gy, 29.29Gy, and 31.44Gy, respectively. At 18 months after radiation therapy, early LR recurrence rate was only 4%. Conclusion. Comprehensive protection of salivary glands minimized xerostomia in head-and-neck cancer patients treated by helical tomotherapy, without increasing early LR recurrence risk.

scholarly journals Evaluation of Protective Effect of Propolis on Parotid Salivary Glands in Gamma-irradiated Rats

2014 ◽  
Vol 15 (1) ◽  
pp. 8-11 ◽  
Author(s):  
Mina Motallebnejad ◽  
Seyed Mohammad Abedi ◽  
M Seyedmajidi ◽  
AA Moghadamnia ◽  
M Ashrafpour ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Salivary Gland ◽  
Protective Effect ◽  
Head And Neck ◽  
Salivary Glands ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Albino Rats ◽  
Significant Difference ◽  
Gamma Irradiated

ABSTRACT Objective and background One of the most significant side effects of radiotherapy for head and neck cancers is xerostomia as a result of salivary gland damage. Considering pharmacological effects of propolis, we evaluated its protective effect on salivary glands subjected to radiotherapy of head and neck cancer patients. Materials and methods Twenty-one male albino rats (8-11 W, 190 ± 5 gm) were divided into three groups of seven animals. Scintigraphy was performed in all the groups. Then groups 1 (S) and 2 (SR) received normal saline injections and group 3 (PR) received propolis injection over 3 days. After that groups 2 and 3 were exposed to gamma radiation and all the rats underwent scintigraphic assessment on third day and 70th day after irradiation. The lips and tongues of rats in groups 2 and 3 were examined for mucositis daily in first 10 days. At the end, the parotid glands of all rats were examined histologically. Results Scintigraphy results of third and 70th day after irradiation showed statistically significant differences between PR and SR as well as SR and S. However, there was no significant difference between the PR and S groups. Histopathologic assessment demonstrated significant difference between SR, PR and S. Conclusion These results suggest that propolis has protective effects on salivary gland function in animal models whilst it did not prevent radiation-induced histologic changes in tissues. Further investigations are needed to elucidate mechanisms of propolis actions. Clinical significance Regarding to the results of this study, propolis may be useful in reduction xerostomia due to radiation to salivary glands and may be helpful for head and neck cancer patients. How to cite this article Motallebnejad M, Abedi SM, Seyedmajidi M, Moghadamnia AA, Ashrafpour M, Salehi M, Moslemi D, Ghorbani A. Evaluation of Protective Effect of Propolis on Parotid Salivary Glands in Gamma-irradiated Rats. J Contemp Dent Pract 2014;15(1):8-11.

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