Suppression of gene expression for proopiomelanocortin (POMC) and melanin-concentrating hormone (MCH) may cause massive obesity in the rainbow trout, Cobalt variant

2000 ◽  
Vol 38 ◽  
pp. S164
Author(s):  
N Naito
1998 ◽  
Vol 839 (1 TRENDS IN COM) ◽  
pp. 397-399
Author(s):  
KAREN FRANCIS ◽  
MASAKAZU SUZUKI ◽  
ANDREW LEVY ◽  
BRIDGET I. BAKER

2009 ◽  
Vol 2009 ◽  
pp. 1-7 ◽  
Author(s):  
Constance Schmelzer ◽  
Mitsuaki Kitano ◽  
Gerald Rimbach ◽  
Petra Niklowitz ◽  
Thomas Menke ◽  
...  

MicroRNAs (miRs) are involved in key biological processes via suppression of gene expression at posttranscriptional levels. According to their superior functions, subtle modulation of miR expression by certain compounds or nutrients is desirable under particular conditions. Bacterial lipopolysaccharide (LPS) induces a reactive oxygen species-/NF-κB-dependent pathway which increases the expression of the anti-inflammatory miR-146a. We hypothesized that this induction could be modulated by the antioxidant ubiquinol-10. Preincubation of human monocytic THP-1 cells with ubiquinol-10 reduced the LPS-induced expression level of miR-146a to 78.9±13.22%. In liver samples of mice injected with LPS, supplementation with ubiquinol-10 leads to a reduction of LPS-induced miR-146a expression to 78.12±21.25%. From these consistent in vitro and in vivo data, we conclude that ubiquinol-10 may fine-tune the inflammatory response via moderate reduction of miR-146a expression.


2019 ◽  
Vol 86 ◽  
pp. 764-771 ◽  
Author(s):  
Patrick C. Blaufuss ◽  
T. Gibson Gaylord ◽  
Wendy M. Sealey ◽  
Madison S. Powell

Sign in / Sign up

Export Citation Format

Share Document