Early steatosis and past HBV infection predict fibrosis progression inliver transplant recipients with recurrent HCV infection

Hepatitis C virus (HCV) infection in the absence of detectable antibodies against HCV and of viral RNA in serum is called occult HCV infection. Its prevalence and clinical significance in chronic hepatitis B virus (HBV) infection is unknown. HCV RNA was tested for in the liver samples of 52 patients with chronic HBV infection and 21 (40 %) of them were positive for viral RNA (occult HCV infection). Liver fibrosis was found more frequently and the fibrosis score was significantly higher in patients with occult HCV than in negative ones, suggesting that occult HCV infection may have an impact on the clinical course of HBV infection.

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Successful sofosbuvir-based therapy in HIV/HCV coinfected liver transplant recipients with recurrent HCV infection

AIDS ◽

10.1097/qad.0000000000000887 ◽

2015 ◽

pp. 1 ◽

Cited By ~ 4

Author(s):

Jennifer L. Grant ◽

Claudia Hawkins ◽

Hannah Brooks ◽

Frank J. Palella ◽

Sean W.P. Koppe ◽

...

Keyword(s):

Liver Transplant ◽

Hcv Infection ◽

Transplant Recipients ◽

Liver Transplant Recipients

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Sofosbuvir and Ribavirin Combination is Safe and Effective in Renal Transplant Recipients with HCV Infection

Journal of Clinical and Experimental Hepatology ◽

10.1016/j.jceh.2016.06.029 ◽

2016 ◽

Vol 6 ◽

pp. S15-S16

Author(s):

Sunil Taneja ◽

Ajay Duseja ◽

Arka De ◽

Vivek Kumar ◽

Raja Ramachandran ◽

...

Keyword(s):

Renal Transplant ◽

Hcv Infection ◽

Renal Transplant Recipients ◽

Transplant Recipients

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Seroprevalence and risk factors for HIV, HCV, HBV and syphilis among blood donors in Mali

BMC Infectious Diseases ◽

10.1186/s12879-019-4699-3 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Aude Jary ◽

Sidi Dienta ◽

Valentin Leducq ◽

Quentin Le Hingrat ◽

Mahamadou Cisse ◽

...

Keyword(s):

Risk Factors ◽

Multivariate Analysis ◽

Marital Status ◽

Blood Donation ◽

Education Level ◽

Male Gender ◽

Hcv Infection ◽

Hbv Infection ◽

Factors Associated ◽

Hcv Prevalence

Abstract Background HIV, HBV and HCV remain a global public health concern especially in Africa. Prevalence of these infections is changing and identification of risk factors associated with each infection in Mali is needed to improve medical care. Methods We conducted a cross-sectional study of all individuals donating blood (n = 8207) in 2018 to the blood bank at university hospital in Bamako, Mali, to assess prevalence and risks factors associated with HIV, HBV, HCV and syphilis infections. Results HIV-seroprevalence was 2.16% and significantly increased with age, being married and decreasing education level. In multivariate analysis, after adjustements with age, marital status and geographical setting, only education level was associated with HIV-infection (OR, 1.54 [95% CI, 1.15–2.07], p = 0.016). HBsAg prevalence was 14.78% and significantly increased with to be male gender. In multivariate analysis, adjusting for age, marital status and type of blood donation, education level (OR, 1.17 [95%CI, 1.05–1.31], p = 0.02) and male gender (OR, 1.37 [95%CI, 1.14–1.65], p = 0.005) were associated with HBV-infection. HCV-prevalence was 2.32% and significantly increased with living outside Bamako. In multivariate analysis, adjusting for gender, age and education level, living outside Bamako was associated with HCV-infection (OR, 1.83 [95% CI, 1.41–2.35], p < 0.001). Syphilis seroprevalence was very low (0.04%) with only 3 individuals infected. Contrary to a prior study, blood donation type was not, after adjustments, an independent risk factor for each infection. Conclusions Overall, HIV and HBV infection was higher in individuals with a lower level of education, HBV infection was higher in men, and HCV infection was higher in people living outside of Bamako. Compared to studies performed in 1999, 2002 and 2007 in the same population, we found that HIV and HCV prevalence have decreased in the last two decades whereas HBV prevalence has remained stable. Our finding will help guide infection prevention and treatment programs in Mali.

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285. Fibrosis Progression and Clinical Outcomes in HCV/HBV Coinfected Persons in the ERCHIVES Cohort

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.360 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S155-S156

Author(s):

Adeel A Butt ◽

Peng Yan ◽

Samia Aslam ◽

Kenneth Sherman ◽

Dawd Siraj ◽

...

Keyword(s):

Clinical Outcomes ◽

Hbv Dna ◽

Hbv Infection ◽

The Other ◽

Hepatic Decompensation ◽

Fibrosis Progression ◽

Hiv Coinfection ◽

The Difference ◽

Incident Rates ◽

Overall Mortality

Abstract Background Progression of liver disease and clinical outcomes in HCV/HBV coinfected persons and how they differ from HCV monoinfected persons and HCV infected persons with resolved HBV infection are not well characterized. We compared incidence of cirrhosis, hepatic decompensation and overall mortality in these three groups. Methods Using the Electronically Retrieved Cohort of HCV-infected Veterans (ERCHIVES), we identified those with HCV infection only, HCV/HBV coinfection (HbsAg or HBV DNA or both positive) or HCV with resolved HBV (HbcAb+ in absence of HbsAg or HBV DNA positivity). We excluded those with HIV coinfection or hepatocellular carcinoma at or before baseline, and those who received any HCV or HBV treatment. Incident rates (95% CI) were determined for cirrhosis, first hepatic decompensation event and overall mortality in the three groups. Results We identified 60,368 HCV monoinfected (Gp A), 151 HCV/HBV coinfected (Gp B) and 19,802 HCV infected with resolved HBV infection (Gp C). Mean age was 61.0, 60.9, and 63.0 years in the three groups and 96.5%, 96.0%, and 97.9% were males. Median baseline FIB-4 index was 2.0, 2.2, and 2.1, respectively. Incident cirrhosis (among those without cirrhosis at baseline) was increased 2- to 2.5-fold in HCV/HBV coinfected persons with baseline FIB-4 of 1.46–3.25. Hepatic decompensation and mortality were also increased several-fold in the HCV/HBV coinfected who had minimal or mild/moderate fibrosis at baseline. However, among those with cirrhosis at baseline, the difference was small among HCV/HBV coinfected and the other groups. Conclusion HCV/HBV coinfected persons with minimal or mild/moderate fibrosis at baseline have a much higher risk of developing cirrhosis, hepatic decompensation and mortality. However, once cirrhosis has is established, the difference is diminished. This underscores the need to intervene early when HCV/HBV coinfected persons still have minimal or mild/moderate fibrosis. Disclosures All authors: No reported disclosures.

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Immune Complex Mediated Glomerulonephritis with Acute Thrombotic Microangiopathy following Newly Detected Hepatitis B Virus Infection in a Kidney Transplant Recipient

Case Reports in Transplantation ◽

10.1155/2016/3152495 ◽

2016 ◽

Vol 2016 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Tracey Salter ◽

Hannah Burton ◽

Sam Douthwaite ◽

William Newsholme ◽

Catherine Horsfield ◽

...

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Kidney Transplant ◽

Immune Complex ◽

Thrombotic Microangiopathy ◽

Hbv Infection ◽

Transplant Recipients ◽

Kidney Transplant Recipients ◽

Vaccine Escape Mutant ◽

B Virus

Hepatitis B virus (HBV) presents a risk to patients and staff in renal units. To minimise viral transmission, there are international and UK guidelines recommending HBV immunisation for patients commencing renal replacement therapy (RRT) and HBV surveillance in kidney transplant recipients. We report the case of a 56-year-old male who was immunised against HBV before starting haemodialysis. He received a deceased donor kidney transplant three years later, at which time there was no evidence of HBV infection. After a further six years he developed an acute kidney injury; allograft biopsy revealed an acute thrombotic microangiopathy (TMA) with glomerulitis, peritubular capillaritis, and C4d staining. Due to a “full house” immunoprofile, tests including virological screening were undertaken, which revealed acute HBV infection. Entecavir treatment resulted in an improvement in viral load and kidney function. HBV genotyping demonstrated a vaccine escape mutant, suggesting “past resolved” infection that reactivated with immunosuppression, though posttransplant acquisition cannot be excluded. This is the first reported case of acute HBV infection associated with immune complex mediated glomerulonephritis and TMA. Furthermore, it highlights the importance of HBV surveillance in kidney transplant recipients, which although addressed by UK guidelines is not currently practiced in all UK units.

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