Peribiliary glands and biliary tree stem cells are involved in the pathogenesis of cholangiocarcinoma arising in patients affected by primary sclerosing cholangitis

2018 ◽  
Vol 68 ◽  
pp. S674
Author(s):  
D. Overi ◽  
V. Cardinale ◽  
T. Folseraas ◽  
G. Carpino ◽  
K. Grzyb ◽  
...  
Keyword(s):  
Stem Cells ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Biliary Tree ◽  
Peribiliary Glands ◽  
Tree Stem

Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis

2015 ◽  
Vol 63 (5) ◽  
pp. 1220-1228 ◽  
Author(s):  
Guido Carpino ◽  
Vincenzo Cardinale ◽  
Anastasia Renzi ◽  
Johannes R. Hov ◽  
Pasquale Bartolomeo Berloco ◽  
...  
Keyword(s):  
Stem Cells ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Biliary Tree ◽  
Peribiliary Glands ◽  
Tree Stem

Hepatic Progenitor Cells and Biliary Tree Stem Cells

2020 ◽  
pp. 29-35 ◽  
Author(s):  
Guido Carpino ◽  
Sergio Morini ◽  
Simone Carotti ◽  
Eugenio Gaudio
Keyword(s):  
Stem Cells ◽  
Progenitor Cells ◽  
Biliary Tree ◽  
Hepatic Progenitor Cells ◽  
Tree Stem

scholarly journals Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Yinka K. Davies ◽  
Cynthia J. Tsay ◽  
Dario V. Caccamo ◽  
Kathleen M. Cox ◽  
Ricardo O. Castillo ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Liver Transplantation ◽  
Primary Sclerosing Cholangitis ◽  
Orthotopic Liver Transplantation ◽  
Successful Treatment ◽  
Sclerosing Cholangitis ◽  
Bile Ducts ◽  
Biliary Tree ◽  
Oral Vancomycin ◽  
Inflammatory Bowel

Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis and cirrhosis of the liver. Due to limited understanding of the etiology and mechanism of PSC, the only existing treatment option is orthotopic liver transplantation (OLT); however, recurrence of PSC, after OLT is estimated to be between 5% and 35%. We discuss the successful treatment of a pediatric patient, with recurrent PSC, after OLT with oral Vancomycin.

Primary Sclerosing Cholangitis

2015 ◽  
Author(s):  
Udayakumar Navaneethan
Keyword(s):  
Differential Diagnosis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Biliary Tree ◽  
Biliary Cirrhosis ◽  
Extrahepatic Bile Ducts ◽  
Biliary Stasis ◽  
Inflammatory Bowel ◽  
Direct Peroral Cholangioscopy ◽  
Secondary Biliary Cirrhosis

Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic disease characterized by inflammation and fibrosis that may involve the entire biliary tree. The fibrosis causes diffuse narrowing of the intrahepatic and extrahepatic bile ducts, and the resulting biliary stasis leads to secondary biliary cirrhosis and associated complications. This review addresses PSC through its epidemiology, etiopathogenesis, diagnosis, differential diagnosis, management, complications, and prognosis. Figures show pouchoscopy, liver biopsy, and endoscopic retrograde cholangiopancreatography; direct peroral cholangioscopy visualization of cholangiocarcinoma; and algorithms depicting diagnosis of cholangiocarcinoma and screening for inflammatory bowel disease (IBD) in patients with PSC. Tables list characteristics of IBD in PSC, prevalence of antibodies in PSC, differential diagnosis of PSC, diagnostic approach in PSC, and risk of cancers in PSC. This review contains 6 highly rendered figures, 5 tables, and 91 references. 

OC.01.1 BILIARY TREE STEM CELLS PLAY A KEY ROLE IN THE REGENERATION OF BILIARY EPITHELIUM AFTER INJURY

2019 ◽  
Vol 51 ◽  
pp. e77
Author(s):  
L. Nevi ◽  
G. Carpino ◽  
V. Cardinale ◽  
W. Lu ◽  
S. Di Matteo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Biliary Tree ◽  
Biliary Epithelium ◽  
Tree Stem
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