Histological and ultrastructural examination of the intrahepatic biliary tree in primary sclerosing cholangitis

2008 ◽  
Vol 6 (6) ◽  
pp. 317-325 ◽  
Author(s):  
Yasuni Nakanuma ◽  
Nobuyuki Hirai ◽  
Naoko Kono ◽  
Goroku Ohta
Keyword(s):  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Biliary Tree ◽  
Ultrastructural Examination

scholarly journals Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Yinka K. Davies ◽  
Cynthia J. Tsay ◽  
Dario V. Caccamo ◽  
Kathleen M. Cox ◽  
Ricardo O. Castillo ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Liver Transplantation ◽  
Primary Sclerosing Cholangitis ◽  
Orthotopic Liver Transplantation ◽  
Successful Treatment ◽  
Sclerosing Cholangitis ◽  
Bile Ducts ◽  
Biliary Tree ◽  
Oral Vancomycin ◽  
Inflammatory Bowel

Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis and cirrhosis of the liver. Due to limited understanding of the etiology and mechanism of PSC, the only existing treatment option is orthotopic liver transplantation (OLT); however, recurrence of PSC, after OLT is estimated to be between 5% and 35%. We discuss the successful treatment of a pediatric patient, with recurrent PSC, after OLT with oral Vancomycin.

Primary Sclerosing Cholangitis

2015 ◽  
Author(s):  
Udayakumar Navaneethan
Keyword(s):  
Differential Diagnosis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Biliary Tree ◽  
Biliary Cirrhosis ◽  
Extrahepatic Bile Ducts ◽  
Biliary Stasis ◽  
Inflammatory Bowel ◽  
Direct Peroral Cholangioscopy ◽  
Secondary Biliary Cirrhosis

Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic disease characterized by inflammation and fibrosis that may involve the entire biliary tree. The fibrosis causes diffuse narrowing of the intrahepatic and extrahepatic bile ducts, and the resulting biliary stasis leads to secondary biliary cirrhosis and associated complications. This review addresses PSC through its epidemiology, etiopathogenesis, diagnosis, differential diagnosis, management, complications, and prognosis. Figures show pouchoscopy, liver biopsy, and endoscopic retrograde cholangiopancreatography; direct peroral cholangioscopy visualization of cholangiocarcinoma; and algorithms depicting diagnosis of cholangiocarcinoma and screening for inflammatory bowel disease (IBD) in patients with PSC. Tables list characteristics of IBD in PSC, prevalence of antibodies in PSC, differential diagnosis of PSC, diagnostic approach in PSC, and risk of cancers in PSC. This review contains 6 highly rendered figures, 5 tables, and 91 references. 

scholarly journals Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis

Hepatology ◽  
2019 ◽  
Vol 71 (3) ◽  
pp. 972-989 ◽  
Author(s):  
Guido Carpino ◽  
Lorenzo Nevi ◽  
Diletta Overi ◽  
Vincenzo Cardinale ◽  
Wei‐Yu Lu ◽  
...  
Keyword(s):  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Biliary Tree ◽  
Tree Regeneration ◽  
Peribiliary Gland

Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis

2015 ◽  
Vol 63 (5) ◽  
pp. 1220-1228 ◽  
Author(s):  
Guido Carpino ◽  
Vincenzo Cardinale ◽  
Anastasia Renzi ◽  
Johannes R. Hov ◽  
Pasquale Bartolomeo Berloco ◽  
...  
Keyword(s):  
Stem Cells ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Biliary Tree ◽  
Peribiliary Glands ◽  
Tree Stem

Primary sclerosing cholangitis

2010 ◽  
pp. 2468-2473
Author(s):  
R.W. Chapman ◽  
K.D. Williamson
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Weight Loss ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Close Association ◽  
Biliary Tree ◽  
Cholestatic Liver Disease ◽  
Immune Mediated ◽  
Inflammatory Bowel

Case History—A 60 yr old woman, known to have long standing colitis, now presenting with abdominal pain and weight loss. Primary sclerosing cholangitis is a chronic cholestatic liver disease caused by diffuse inflammation and fibrosis that can involve the entire biliary tree. The cause is unknown, but presumed to be immune mediated, and there is a very close association with inflammatory bowel disease, particularly ulcerative colitis....

scholarly journals Primary sclerosing cholangitis, the biliary tree, and ulcerative colitis.

Gut ◽  
1967 ◽  
Vol 8 (5) ◽  
pp. 435-448 ◽  
Author(s):  
M E Thorpe ◽  
P J Scheuer ◽  
S Sherlock
Keyword(s):  
Ulcerative Colitis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Biliary Tree
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