Evolution of hepatitis C virus genotype 1a vs 1b distribution reflects profound changes in HCV epidemiology in Germany - analysis of 17,093 patients from five consecutive registries including the German hepatitis C-registry (DHC-R)

2020 ◽  
Vol 73 ◽  
pp. S348-S349
Author(s):  
Karl-Georg Simon ◽  
Yvonne Serfert ◽  
Peter Buggisch ◽  
Stefan Mauss ◽  
Klaus Boeker ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Genotype ◽  
Genotype 1A

scholarly journals NS3 Variability in Hepatitis C Virus Genotype 1A Isolates from Liver Tissue and Serum Samples of Treatment-Naïve Patients with Chronic Hepatitis C

Intervirology ◽  
2018 ◽  
Vol 61 (1) ◽  
pp. 1-8
Author(s):  
Deborah D’Aliberti ◽  
Irene Cacciola ◽  
Cristina Musolino ◽  
Giuseppina Raffa ◽  
Roberto Filomia ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Tissue ◽  
Serum Samples ◽  
Virus Genotype ◽  
Genotype 1A ◽  
Treatment Naïve

A large healthcare-associated outbreak of hepatitis C virus genotype 1a in a clinic in Korea

2018 ◽  
Vol 106 ◽  
pp. 53-57 ◽  
Author(s):  
Yoon-Seok Chung ◽  
Ju-yeon Choi ◽  
Myung Guk Han ◽  
Kye Ryeong Park ◽  
Su-Jin Park ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Genotype ◽  
Genotype 1A ◽  
Healthcare Associated

Treatment outcomes in hepatitis C virus genotype 1a infected patients with and without baseline NS5A resistance‐associated substitutions

2020 ◽  
Vol 40 (11) ◽  
pp. 2660-2671
Author(s):  
Julia Dietz ◽  
Johannes Vermehren ◽  
Katrin Matschenz ◽  
Peter Buggisch ◽  
Hartwig Klinker ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Treatment Outcomes ◽  
Virus Genotype ◽  
Genotype 1A

scholarly journals The spread of hepatitis C virus genotype 1a in North America: a retrospective phylogenetic study

2016 ◽  
Vol 16 (6) ◽  
pp. 698-702 ◽  
Author(s):  
Jeffrey B Joy ◽  
Rosemary M McCloskey ◽  
Thuy Nguyen ◽  
Richard H Liang ◽  
Yury Khudyakov ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
North America ◽  
Phylogenetic Study ◽  
Virus Genotype ◽  
Genotype 1A

The accuracy of baseline viral load for predicting the efficacy of elbasvir/grazoprevir in participants with hepatitis C virus genotype 1a infection: An integrated analysis

2019 ◽  
Vol 26 (3) ◽  
pp. 329-336 ◽  
Author(s):  
Lawrence Serfaty ◽  
Ira Jacobson ◽  
Jürgen Rockstroh ◽  
Frederick L. Altice ◽  
Peggy Hwang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
Baseline Viral Load ◽  
Integrated Analysis ◽  
Virus Genotype ◽  
Genotype 1A

scholarly journals Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets

2005 ◽  
Vol 86 (9) ◽  
pp. 2507-2512 ◽  
Author(s):  
Eriko Yamada ◽  
Maria Montoya ◽  
Christian G. Schuettler ◽  
Timothy P. Hickling ◽  
Alexander W. Tarr ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Peripheral Blood Mononuclear Cell ◽  
Mononuclear Cell ◽  
Peripheral Blood ◽  
Type I ◽  
Cell Infection ◽  
Virus Genotype ◽  
Peripheral Blood Mononuclear ◽  
Genotype 1A

Hepatitis C virus (HCV) binding to hepatocytes is thought to be mediated via interaction of the E2 glycoprotein with (co-)receptors including CD81 and scavenger receptor class B type I (SR-BI). Here, the expression of CD81 and SR-BI was analysed on peripheral blood mononuclear cell (PBMC) subsets, and the binding of genotype 1 soluble truncated E2 (sE2) proteins to these cells was investigated. All PBMC subsets expressed CD81, although at varying levels. In contrast, SR-BI was only detected on monocytes and dendritic cells (DCs). The genotype 1a H77c sE2 protein showed higher PBMC binding than other genotype 1a/b sE2s. H77c sE2 binding to different PBMC subsets largely paralleled their level of CD81 expression, and could be inhibited by blocking E2–CD81 interaction. However, those PBMC subsets reported to be infected by HCV in vivo (monocytes, DCs and B cells) also exhibited residual, CD81-independent binding, indicating roles for SR-BI/other receptor(s) in mediating haematopoietic cell infection.

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