Tumor suppressor genes: At the crossroads of molecular carcinogenesis, molecular epidemiology and cancer therapy

Lung Cancer ◽  
1997 ◽  
Vol 18 ◽  
pp. 113 ◽  
Author(s):  
Curtis C. Harris
Keyword(s):  
Cancer Therapy ◽  
Tumor Suppressor ◽  
Molecular Epidemiology ◽  
Tumor Suppressor Genes ◽  
Suppressor Genes ◽  
Molecular Carcinogenesis

scholarly journals Alive failures behind the windows of cancer therapy

2017 ◽  
Vol 5 (2) ◽  
pp. 179
Author(s):  
Muhammad Islam
Keyword(s):  
Cancer Therapy ◽  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Therapeutic Strategies ◽  
Cancer Therapies ◽  
Physiological System ◽  
Suppressor Genes ◽  
Immune Therapies

The multiscope process, cancer is attributable from various geneses. Eventually, cancer is a complicated disease with unconstrained interca-lation and impacts on the physiological system. Therefore, an ideal cancer therapy must be like a multi-edged sword. Broadly, currently, available cancer therapies are the cytoprotective, inhibitors of oncogenes, correctors, and cell destructors. Doubtless, cancer therapists are most frequently handling apoptosis and autophagy inducers, targeting of tumor suppressor genes, epigenetic and immune therapies. How-ever, each therapy has a number of challenges yet to be resolved. This revision is aimed to find out some important points, depicting till the date, how successful we are and what are the failures behind those modes of therapeutic strategies.

scholarly journals Targeting tumor suppressor genes for cancer therapy

BioEssays ◽  
2015 ◽  
Vol 37 (12) ◽  
pp. 1277-1286 ◽  
Author(s):  
Yunhua Liu ◽  
Xiaoxiao Hu ◽  
Cecil Han ◽  
Liana Wang ◽  
Xinna Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Suppressor Genes

Regulation of cell death mechanisms by melatonin: implications to cancer therapy

2021 ◽  
Vol 21 ◽  
Author(s):  
Zicheng Wang ◽  
Yanqing Liu ◽  
Ahmed Eleojo Musa
Keyword(s):  
Cell Death ◽  
Cancer Therapy ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Genes ◽  
Mammalian Target Of Rapamycin ◽  
Therapeutic Modality ◽  
Mitotic Catastrophe ◽  
Suppressor Genes ◽  
Tensin Homolog

: Cancer therapy is based on the killing of cancer cells using various therapeutic agents such as radiation, chemotherapy or targeted therapy drugs and immunotherapy. Cancer cells may undergo apoptosis, mitotic catastrophe, necrosis, autophagy, mitophagy, senescence etc., depending on the therapeutic modality and nature of cancer cells. Mutations in some critical genes such as p53 and phosphatase and tensin homolog (PTEN) tumor suppressor genes are associated with immune escaping cancer cells and progression towards tumor progression. Furthermore, the overexpression of some genes such as phosphatidylinositol-3-kinase (PI3K), nuclear factor of Kappa B (NF-κB), cyclooxygenase-2 (COX-2) and mammalian target of rapamycin (mTOR) is associated with resistance of cancer cells to various types of cell death. Melatonin is known as a circadian regulator hormone that has several anti-cancer properties. It has ability to activate tumor suppressor genes and attenuate the expression of survival genes in cancer cells. Modulation of cell death or survival genes that have been disrupted or overexpressed in cancer cells can improve cancer therapy. In this review, we explain the potentials of melatonin in regulating various mechanisms of cancer cell death.

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