Cardiovascular risk factors and Alzheimer's disease: Genetic association studies in a population aged 85+

This chapter provides a brief overview concerning the global epidemic, risk and protective factors, and possible intervention strategies of Alzheimer’s disease, the most common type of dementia. Alzheimer’s disease, which is projected to reach global epidemic level in three to four decades, already has a huge economic and societal impact. Epidemiologic research has provided sufficient evidence supporting that lifestyle or cardiovascular risk factors in middle-aged and older adults play a critical role in the onset and progression of late-life dementia and Alzheimer’s disease, whereas active engagement in mental, social, and physical activities may postpone the onset of the dementing disorders. The community intervention studies are warranted to determine to what extent intervention strategies towards control of major lifestyle and cardiovascular risk factors and related vascular disorders as well as maintenance of an active lifestyle may help delay the onset of Alzheimer’s disease and dementia syndrome.

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Genetic association studies in Alzheimer's disease research: challenges and opportunities

Statistics in Medicine ◽

10.1002/sim.1706 ◽

2004 ◽

Vol 23 (2) ◽

pp. 169-178 ◽

Cited By ~ 11

Author(s):

Steven D. Edland ◽

Susan Slager ◽

Matthew Farrer

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Genetic Association ◽

Association Studies ◽

Genetic Association Studies ◽

Disease Research ◽

Research Challenges ◽

Challenges And Opportunities

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Cardiovascular risk factors and future risk of Alzheimer’s disease

BMC Medicine ◽

10.1186/s12916-014-0130-5 ◽

2014 ◽

Vol 12 (1) ◽

Cited By ~ 125

Author(s):

Renée FAG de Bruijn ◽

M Arfan Ikram

Keyword(s):

Risk Factors ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Future Risk

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The Role of Cardiovascular Risk Factors in Alzheimer's Disease

CNS Spectrums ◽

10.1017/s109285290001926x ◽

2003 ◽

Vol 8 (11) ◽

pp. 824-831 ◽

Cited By ~ 13

Author(s):

Ramit Ravona-Springer ◽

Michael Davidson ◽

Shlomo Noy

Keyword(s):

Risk Factors ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cardiovascular Risk ◽

Vascular Dementia ◽

Cardiovascular Risk Factors ◽

Treatment Strategies ◽

Mechanisms Of Action ◽

Clinical Imaging

ABSTRACTThe distinction between Alzheimer's disease and vascular dementia, the two most common types of dementia, has been undermined by recent advances in epidemiologic, clinical, imaging, and neuropathological studies. Cardiovascular risk factors, traditionally regarded as distinguishing criteria between the two entities, have been shown to be associated with both AD and vascular dementia. In this article, we propose mechanisms of action of cardiovascular risk factors in AD, suggest possible explanations for the overlap with vascular dementia and discuss the implications this might have on future differential diagnosis, research, and treatment strategies.

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