Induction of hepatitis B virus-specific cytotoxic T lymphocytes response in vivo by filamentous phage display vaccine

Vaccine ◽  
2001 ◽  
Vol 19 (20-22) ◽  
pp. 2918-2923 ◽  
Author(s):  
Ying Wan ◽  
Yuzhang Wu ◽  
Jiang Bian ◽  
XiangZhi Wang ◽  
Wei Zhou ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Lymphocytes ◽  
Hepatitis B ◽  
Phage Display ◽  
Cytotoxic T Lymphocytes ◽  
Filamentous Phage ◽  
B Virus

scholarly journals Blocking Chemokine Responsive to γ–2/Interferon (IFN)-γ Inducible Protein and Monokine Induced by IFN-γ Activity In Vivo Reduces the Pathogenetic but not the Antiviral Potential of Hepatitis B Virus–specific Cytotoxic T Lymphocytes

2001 ◽  
Vol 194 (12) ◽  
pp. 1755-1766 ◽  
Author(s):  
Kazuhiro Kakimi ◽  
Thomas E. Lane ◽  
Stefan Wieland ◽  
Valerie C. Asensio ◽  
Iain L. Campbell ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Lymphocytes ◽  
Hepatitis B ◽  
Cytotoxic T Lymphocytes ◽  
Interferon Γ ◽  
Nonparenchymal Cells ◽  
B Virus ◽  
Ifn Γ ◽  
Inducible Protein

Using transgenic mice that replicate hepatitis B virus (HBV) at high levels in the liver as recipients of HBV-specific cytotoxic T lymphocytes (CTLs), we showed that the chemokines responsive to γ–2/IFN-γ inducible protein ([Crg2]IP-10) and monokine induced by interferon-γ (Mig) are rapidly and strongly induced in the liver after CTL transfer. The transferred CTLs produce neither chemokine; rather, they activate (via the secretion of IFN-γ) hepatocytes and nonparenchymal cells of the liver to produce (Crg2)IP-10 and Mig. Importantly, blocking these chemokines in vivo reduces the recruitment of host-derived lymphomononuclear cells into the liver and the severity of the liver disease without affecting the IFN-γ–dependent antiviral potential of the CTLs. The finding that neutralization of these chemokines is associated with maintenance of antiviral effects but diminished tissue damage may be significant for the development of immunotherapeutic approaches for the treatment of chronic HBV infection.

A Method to Detect Hepatitis B Virus-specific Cytotoxic T Lymphocytes in Patients with Acute and Chronic HBV Infection

1994 ◽  
pp. 168-172
Author(s):  
Geert Leroux-Roels ◽  
Els Van Hecke ◽  
Jozef Paradijs ◽  
Chantal Molitor ◽  
Carine Bastin ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Lymphocytes ◽  
Hepatitis B ◽  
Cytotoxic T Lymphocytes ◽  
Hbv Infection ◽  
Chronic Hbv Infection ◽  
B Virus ◽  
Chronic Hbv

scholarly journals Intracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes

Immunity ◽  
1996 ◽  
Vol 4 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Luca G Guidotti ◽  
Tetsuya Ishikawa ◽  
Monte V Hobbs ◽  
Brent Matzke ◽  
Robert Schreiber ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Lymphocytes ◽  
Hepatitis B ◽  
Cytotoxic T Lymphocytes ◽  
B Virus

Cytotoxic T lymphocytes recognize an HLA-A2 restricted epitope within the hepatitis B virus nucleocapsid antigen

1991 ◽  
Vol 13 ◽  
pp. S59
Author(s):  
A. Penna ◽  
F.V. Chisari ◽  
A. Bertoletti ◽  
G. Missale ◽  
T. Giuberti ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Lymphocytes ◽  
Hepatitis B ◽  
Cytotoxic T Lymphocytes ◽  
B Virus ◽  
Restricted Epitope
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