Cortical bone grafts used to culture bone cells to be used for increasing efficacy of bone morphogenetic proteins in tissue engineered bone substitutes

2003 ◽  
Vol 61 (8) ◽  
pp. 74 ◽  
Author(s):  
Tom C. Lindholm ◽  
SAF Peel ◽  
CML Clokie ◽  
GKB Sandor
Keyword(s):  
Cortical Bone ◽  
Bone Morphogenetic Proteins ◽  
Bone Cells ◽  
Bone Grafts ◽  
Bone Substitutes

Effect of Osteoplasty with Bioactive Glass (S53P4) in Bone Healing - In vivo Experiment on Common European Rabbits (Oryctolagus cuniculus)

2018 ◽  
Vol 69 (2) ◽  
pp. 429-433
Author(s):  
Solyom Arpad ◽  
Cristian Trambitas ◽  
Ecaterina Matei ◽  
Eugeniu Vasile ◽  
Fodor Pal ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Fractures ◽  
Healing Process ◽  
Bone Grafts ◽  
Bone Substitutes ◽  
Native Bone ◽  
European Rabbits ◽  
Autologous Bone Grafts ◽  
Fracture Types

Osteoplasty, is a procedure mostly applied in complicated bone fractures. Nowadays this method is widely used in primary fracture treatment while the native bone graft is progressively replaced with various synthetic bone substitutes. From the numerous bone grafts we�d like to mention a representative of ceramics, the S53P4 bioactive glass. (BonAlive�). The aim of this study was to investigate the healing process of different fracture types generated on rabbit femurs. During this experiment we used seven common European rabbits. We separated these animals into two groups; in the first group we surgically generated a total fracture in the middle 1/3 of the femur, while in the second group, we produced only a bone defect on the femur. The osteoplasty was carried out with bioactive glass and autologous bone grafts. The radiographic follow-up was immediate after the operation and after 3, 6 and 7 weeks. The animals were euthanized after 19, 20 and 21 weeks, for histomorphometric examination of the femur. It was also studied the ionic release from the used bioactive glass at physiological pH and the etching of the glass was studied by Scanning Electron Microscopy.

scholarly journals Nanocomposites of Chitosan/Graphene Oxide/Titanium Dioxide Nanoparticles/Blackberry Waste Extract as Potential Bone Substitutes

Polymers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 3877
Author(s):  
Carlos Humberto Valencia-Llano ◽  
Moisés A. Solano ◽  
Carlos David Grande-Tovar
Keyword(s):  
Titanium Dioxide ◽  
Graphene Oxide ◽  
New Technologies ◽  
Bone Structure ◽  
Bone Cells ◽  
Critical Size ◽  
Titanium Dioxide Nanoparticles ◽  
Bone Substitutes ◽  
Critical Size Defect ◽  
Waste Extract

New technologies based on nanocomposites of biopolymers and nanoparticles inspired by the nature of bone structure have accelerated their application in regenerative medicine, thanks to the introduction of reinforcing properties. Our research incorporated chitosan (CS) covalently crosslinked with glutaraldehyde (GLA) beads with graphene oxide (GO) nanosheets, titanium dioxide nanoparticles (TiO2), and blackberry processing waste extract (BBE) and evaluated them as partial bone substitutes. Skullbone defects in biomodels filled with the scaffolds showed evidence through light microscopy, scanning electron microscopy, histological studies, soft tissue development with hair recovery, and absence of necrotic areas or aggressive infectious response of the immune system after 90 days of implantation. More interestingly, newly formed bone was evidenced by elemental analysis and Masson trichromacy analysis, which demonstrated a possible osteoinductive effect from the beads using the critical size defect experimental design in the biomodels. The results of this research are auspicious for the development of bone substitutes and evidence that the technologies for tissue regeneration, including chitosan nanocomposites, are beneficial for the adhesion and proliferation of bone cells.

scholarly journals Prediction Modeling and Sensitivity Analysis of Robot Bone Milling Temperature Operated by a Doctor

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Heqiang Tian ◽  
Jingbo Pan ◽  
Yu Gao ◽  
Xiaoqing Dang ◽  
Bin Tian ◽  
...  
Keyword(s):  
Prediction Model ◽  
Cortical Bone ◽  
Cancellous Bone ◽  
Bone Cells ◽  
Prediction Method ◽  
Milling Process ◽  
Milling Parameters ◽  
Cutting Surface ◽  
Milling Temperature ◽  
Cutting Modes

Bone milling is a common method in robot orthopedic surgery. However, excessive milling temperature will cause thermal necrosis of bone cells and tissues. It is necessary to carry out further research and analysis on the robot bone milling process considering the lamina milling skills of spinal surgeons and clinical practice to reduce the damage to bone cells and nearby tissues and obtain good cutting surface quality. Considering the randomness of milling parameters during operation, a prediction method of milling temperature model for ball milling cutter considering the doctor’s surgical skills was proposed based on response surface method. Because of material anisotropy and microstructure difference between the cortical bone and cancellous bone, this paper would analyze the influencing factors in different bone layers to establish the prediction model of milling temperature in the segments of cortical bone and cancellous bone. Also, the influence and distribution of milling parameters on temperature in three cutting modes such as parallel cutting mode, cross cutting mode, and vertical cutting mode in the cortical bone region were analyzed. The parameter sensitivity of the milling temperature prediction model was analyzed by the Sobol method, and the influence of the input parameters on the output milling temperature was analyzed quantitatively.

Healing of Cortical Bone Grafts in the Dog The Role of Azathioprine

1982 ◽  
Vol 11 (2) ◽  
pp. 52-59 ◽  
Author(s):  
BAYO J. ADEYANJU ◽  
HUGH C. BUTLER ◽  
HORST W. LEIPOLD
Keyword(s):  
Cortical Bone ◽  
Bone Grafts
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