Nanocomposites of Chitosan/Graphene Oxide/Titanium Dioxide Nanoparticles/Blackberry Waste Extract as Potential Bone Substitutes

New technologies based on nanocomposites of biopolymers and nanoparticles inspired by the nature of bone structure have accelerated their application in regenerative medicine, thanks to the introduction of reinforcing properties. Our research incorporated chitosan (CS) covalently crosslinked with glutaraldehyde (GLA) beads with graphene oxide (GO) nanosheets, titanium dioxide nanoparticles (TiO2), and blackberry processing waste extract (BBE) and evaluated them as partial bone substitutes. Skullbone defects in biomodels filled with the scaffolds showed evidence through light microscopy, scanning electron microscopy, histological studies, soft tissue development with hair recovery, and absence of necrotic areas or aggressive infectious response of the immune system after 90 days of implantation. More interestingly, newly formed bone was evidenced by elemental analysis and Masson trichromacy analysis, which demonstrated a possible osteoinductive effect from the beads using the critical size defect experimental design in the biomodels. The results of this research are auspicious for the development of bone substitutes and evidence that the technologies for tissue regeneration, including chitosan nanocomposites, are beneficial for the adhesion and proliferation of bone cells.

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Graphene oxide decorated with zinc oxide nanoflower, silver and titanium dioxide nanoparticles: fabrication, characterization, DNA interaction, and antibacterial activity

RSC Advances ◽

10.1039/c8ra09788g ◽

2019 ◽

Vol 9 (7) ◽

pp. 3704-3714 ◽

Cited By ~ 22

Author(s):

Nagi El-Shafai ◽

Mohamed E. El-Khouly ◽

Maged El-Kemary ◽

Mohamed Ramadan ◽

Ibrahim Eldesoukey ◽

...

Keyword(s):

Zinc Oxide ◽

Antibacterial Activity ◽

Titanium Dioxide ◽

Graphene Oxide ◽

Titanium Dioxide Nanoparticles ◽

Dna Interaction

The fabrication, characterization, and antibacterial activity of novel nanocomposites based on graphene oxide (GO) nanosheets decorated with silver, titanium dioxide nanoparticles, and zinc oxide nanoflowers were examined.

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Photocatalytic Activity of Titanium Dioxide Nanoparticles Linked on Chemically Reduced Graphene Oxide through Mussel-inspired Chemistry

Chemistry Letters ◽

10.1246/cl.150256 ◽

2015 ◽

Vol 44 (8) ◽

pp. 1068-1070 ◽

Cited By ~ 3

Author(s):

Chang Eun Oh ◽

Young Ho Park ◽

Sungmin Kim ◽

Donggun Lim ◽

Sung Young Park ◽

...

Keyword(s):

Titanium Dioxide ◽

Photocatalytic Activity ◽

Graphene Oxide ◽

Reduced Graphene Oxide ◽

Titanium Dioxide Nanoparticles ◽

Reduced Graphene ◽

Chemically Reduced Graphene Oxide

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Biosynthesis and Characterization of Titanium Dioxide Nanoparticles Using Pithecellobium Dulce and Lagenaria Siceraria Aqueous Leaf Extract and Screening their Free Radical Scavenging and Antibacterial Properties

International Letters of Chemistry Physics and Astronomy ◽

10.18052/www.scipress.com/ilcpa.50.80 ◽

2015 ◽

Vol 50 ◽

pp. 80-95 ◽

Cited By ~ 7

Author(s):

S. Kalyanasundaram ◽

M. Jeevan Prakash

Keyword(s):

Titanium Dioxide ◽

New Technologies ◽

Titanium Dioxide Nanoparticles ◽

Radical Scavenging ◽

Antibacterial Properties ◽

Biological Method ◽

Lagenaria Siceraria ◽

Biological Behaviour ◽

Synthesis Of Nanoparticles ◽

Xrd Techniques

The recent development and implementation of new technologies have led to new era, the nanorevolution which unfolds role of plants in bio and green synthesis of nanoparticles which seem to have drawn quite an unequivocal attention with a view of synthesizing stable nanoparticles. In this present work, we have compared titanium dioxide nanocrystals synthesized by both chemical method and biological method from Titanium tetra isopropoxide as precursor. The biological method was performed by using the aqueous plant extract of Pithecellobium dulce and Lagenaria siceraria. The synthesized nanocrystals were characterized by FTIR Spectroscopy, Scanning Electron Microscopy (SEM), Energy Dispersive Xray (EDAX), Transmission Electron Microscope (TEM) and X-ray diffraction (XRD) techniques and also Antioxidant assay and antimicrobial test were performed to evaluate its biological behaviour. The nanocrystals synthesized by biological method were found to have higher antioxidant potential, antimicrobial activity than chemically synthesized.

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